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IONIS PHARMACEUTICALS INC (IONS) Stock Fundamental Analysis

NASDAQ:IONS - Nasdaq - US4622221004 - Common Stock - Currency: USD

33.4  -0.06 (-0.18%)

Fundamental Rating

3

Taking everything into account, IONS scores 3 out of 10 in our fundamental rating. IONS was compared to 560 industry peers in the Biotechnology industry. The financial health of IONS is average, but there are quite some concerns on its profitability. IONS is valied quite expensively at the moment, while it does show a decent growth rate.


Dividend Valuation Growth Profitability Health

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2

1. Profitability

1.1 Basic Checks

In the past year IONS has reported negative net income.
In the past year IONS has reported a negative cash flow from operations.
IONS had negative earnings in each of the past 5 years.
In multiple years IONS reported negative operating cash flow during the last 5 years.
IONS Yearly Net Income VS EBIT VS OCF VS FCFIONS Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 200M -200M 400M -400M 600M

1.2 Ratios

IONS has a better Return On Assets (-16.28%) than 80.54% of its industry peers.
The Return On Equity of IONS (-96.28%) is comparable to the rest of the industry.
Industry RankSector Rank
ROA -16.28%
ROE -96.28%
ROIC N/A
ROA(3y)-12.67%
ROA(5y)-11.54%
ROE(3y)-72.98%
ROE(5y)-56.49%
ROIC(3y)N/A
ROIC(5y)N/A
IONS Yearly ROA, ROE, ROICIONS Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 20 -20 -40 -60 -80

1.3 Margins

IONS has a Gross Margin of 98.53%. This is amongst the best in the industry. IONS outperforms 97.68% of its industry peers.
In the last couple of years the Gross Margin of IONS has remained more or less at the same level.
IONS does not have Profit Margin and Operating Margin available, so we won't be analyzing them here.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM 98.53%
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.08%
GM growth 5Y-0.24%
IONS Yearly Profit, Operating, Gross MarginsIONS Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 50 -50

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2. Health

2.1 Basic Checks

IONS does not have a ROIC to compare to the WACC, probably because it is not profitable.
IONS has more shares outstanding than it did 1 year ago.
The number of shares outstanding for IONS has been increased compared to 5 years ago.
The debt/assets ratio for IONS has been reduced compared to a year ago.
IONS Yearly Shares OutstandingIONS Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 50M 100M 150M
IONS Yearly Total Debt VS Total AssetsIONS Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 1B 2B 3B

2.2 Solvency

IONS has an Altman-Z score of 0.80. This is a bad value and indicates that IONS is not financially healthy and even has some risk of bankruptcy.
IONS has a better Altman-Z score (0.80) than 68.21% of its industry peers.
IONS has a Debt/Equity ratio of 2.63. This is a high value indicating a heavy dependency on external financing.
The Debt to Equity ratio of IONS (2.63) is worse than 82.86% of its industry peers.
Industry RankSector Rank
Debt/Equity 2.63
Debt/FCF N/A
Altman-Z 0.8
ROIC/WACCN/A
WACC8.6%
IONS Yearly LT Debt VS Equity VS FCFIONS Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M -500M 1B

2.3 Liquidity

IONS has a Current Ratio of 9.66. This indicates that IONS is financially healthy and has no problem in meeting its short term obligations.
With a decent Current ratio value of 9.66, IONS is doing good in the industry, outperforming 78.04% of the companies in the same industry.
A Quick Ratio of 9.62 indicates that IONS has no problem at all paying its short term obligations.
IONS has a better Quick ratio (9.62) than 78.04% of its industry peers.
Industry RankSector Rank
Current Ratio 9.66
Quick Ratio 9.62
IONS Yearly Current Assets VS Current LiabilitesIONS Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B 1.5B 2B 2.5B

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4

3. Growth

3.1 Past

IONS shows a strong negative growth in Earnings Per Share. In the last year the EPS decreased by -11.99%.
The Revenue has decreased by -7.64% in the past year.
IONS shows a decrease in Revenue. Measured over the last years, the Revenue has been decreasing by -8.88% yearly.
EPS 1Y (TTM)-11.99%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%5.1%
Revenue 1Y (TTM)-7.64%
Revenue growth 3Y-4.54%
Revenue growth 5Y-8.88%
Sales Q2Q%10.92%

3.2 Future

Based on estimates for the next years, IONS will show a very strong growth in Earnings Per Share. The EPS will grow by 24.50% on average per year.
The Revenue is expected to grow by 28.37% on average over the next years. This is a very strong growth
EPS Next Y-6.51%
EPS Next 2Y-0.58%
EPS Next 3Y14.37%
EPS Next 5Y24.5%
Revenue Next Year19.72%
Revenue Next 2Y19.3%
Revenue Next 3Y24.13%
Revenue Next 5Y28.37%

3.3 Evolution

The Revenue growth rate is accelerating: in the next years the growth will be better than in the last years.
IONS Yearly Revenue VS EstimatesIONS Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 1B 2B 3B
IONS Yearly EPS VS EstimatesIONS Yearly EPS VS EstimatesYearly EPS VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 0 2 -2 4 6

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0

4. Valuation

4.1 Price/Earnings Ratio

The Price/Earnings Ratio is negative for IONS. In the last year negative earnings were reported.
Besides the negative Price/Earnings Ratio, also the Forward Price/Earnings Ratio is negative for IONS. No positive earnings are expected for the next year.
Industry RankSector Rank
PE N/A
Fwd PE N/A
IONS Price Earnings VS Forward Price EarningsIONS Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
IONS Per share dataIONS EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 2 -2 4

4.3 Compensation for Growth

IONS's earnings are expected to grow with 14.37% in the coming years. This may justify a more expensive valuation.
PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y-0.58%
EPS Next 3Y14.37%

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0

5. Dividend

5.1 Amount

IONS does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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IONIS PHARMACEUTICALS INC

NASDAQ:IONS (5/30/2025, 11:32:57 AM)

33.4

-0.06 (-0.18%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)04-30 2025-04-30/bmo
Earnings (Next)07-30 2025-07-30/bmo
Inst Owners103.97%
Inst Owner Change2.53%
Ins Owners0.79%
Ins Owner Change11.72%
Market Cap5.32B
Analysts80
Price Target59.07 (76.86%)
Short Float %9.45%
Short Ratio8.27
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)2
Avg EPS beat(2)30.37%
Min EPS beat(2)18.36%
Max EPS beat(2)42.39%
EPS beat(4)4
Avg EPS beat(4)33.09%
Min EPS beat(4)18.36%
Max EPS beat(4)52.1%
EPS beat(8)8
Avg EPS beat(8)33.95%
EPS beat(12)10
Avg EPS beat(12)22.81%
EPS beat(16)13
Avg EPS beat(16)43.75%
Revenue beat(2)2
Avg Revenue beat(2)32.49%
Min Revenue beat(2)3.26%
Max Revenue beat(2)61.73%
Revenue beat(4)4
Avg Revenue beat(4)28.28%
Min Revenue beat(4)0.96%
Max Revenue beat(4)61.73%
Revenue beat(8)7
Avg Revenue beat(8)27.53%
Revenue beat(12)9
Avg Revenue beat(12)18.05%
Revenue beat(16)11
Avg Revenue beat(16)16.69%
PT rev (1m)-1.46%
PT rev (3m)-5.06%
EPS NQ rev (1m)41.04%
EPS NQ rev (3m)41.5%
EPS NY rev (1m)16.9%
EPS NY rev (3m)16.27%
Revenue NQ rev (1m)72.01%
Revenue NQ rev (3m)55.53%
Revenue NY rev (1m)11.81%
Revenue NY rev (3m)9.58%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S 7.41
P/FCF N/A
P/OCF N/A
P/B 11.17
P/tB 11.17
EV/EBITDA N/A
EPS(TTM)-2.99
EYN/A
EPS(NY)-3.08
Fwd EYN/A
FCF(TTM)-3.49
FCFYN/A
OCF(TTM)-3.15
OCFYN/A
SpS4.51
BVpS2.99
TBVpS2.99
PEG (NY)N/A
PEG (5Y)N/A
Profitability
Industry RankSector Rank
ROA -16.28%
ROE -96.28%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM 98.53%
FCFM N/A
ROA(3y)-12.67%
ROA(5y)-11.54%
ROE(3y)-72.98%
ROE(5y)-56.49%
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexcg growth 3YN/A
ROICexcg growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.08%
GM growth 5Y-0.24%
F-Score2
Asset Turnover0.25
Health
Industry RankSector Rank
Debt/Equity 2.63
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 245.51%
Cap/Sales 7.44%
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 9.66
Quick Ratio 9.62
Altman-Z 0.8
F-Score2
WACC8.6%
ROIC/WACCN/A
Cap/Depr(3y)135.24%
Cap/Depr(5y)139.85%
Cap/Sales(3y)4.04%
Cap/Sales(5y)3.68%
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)-11.99%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%5.1%
EPS Next Y-6.51%
EPS Next 2Y-0.58%
EPS Next 3Y14.37%
EPS Next 5Y24.5%
Revenue 1Y (TTM)-7.64%
Revenue growth 3Y-4.54%
Revenue growth 5Y-8.88%
Sales Q2Q%10.92%
Revenue Next Year19.72%
Revenue Next 2Y19.3%
Revenue Next 3Y24.13%
Revenue Next 5Y28.37%
EBIT growth 1Y-22.03%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year5.58%
EBIT Next 3Y19.87%
EBIT Next 5YN/A
FCF growth 1Y-38.72%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-33.21%
OCF growth 3YN/A
OCF growth 5YN/A