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IONIS PHARMACEUTICALS INC (IONS) Stock Fundamental Analysis

USA - NASDAQ:IONS - US4622221004 - Common Stock

73.12 USD
-0.88 (-1.19%)
Last: 11/20/2025, 8:00:02 PM
73.85 USD
+0.73 (+1%)
After Hours: 11/20/2025, 8:00:02 PM
Fundamental Rating

3

Overall IONS gets a fundamental rating of 3 out of 10. We evaluated IONS against 533 industry peers in the Biotechnology industry. Both the profitability and financial health of IONS have multiple concerns. While showing a medium growth rate, IONS is valued expensive at the moment.


Dividend Valuation Growth Profitability Health

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3

1. Profitability

1.1 Basic Checks

IONS had negative earnings in the past year.
IONS had a negative operating cash flow in the past year.
In the past 5 years IONS always reported negative net income.
In multiple years IONS reported negative operating cash flow during the last 5 years.
IONS Yearly Net Income VS EBIT VS OCF VS FCFIONS Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 200M -200M 400M -400M 600M

1.2 Ratios

Looking at the Return On Assets, with a value of -8.45%, IONS belongs to the top of the industry, outperforming 84.80% of the companies in the same industry.
With a decent Return On Equity value of -41.48%, IONS is doing good in the industry, outperforming 70.54% of the companies in the same industry.
Industry RankSector Rank
ROA -8.45%
ROE -41.48%
ROIC N/A
ROA(3y)-12.67%
ROA(5y)-11.54%
ROE(3y)-72.98%
ROE(5y)-56.49%
ROIC(3y)N/A
ROIC(5y)N/A
IONS Yearly ROA, ROE, ROICIONS Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 20 -20 -40 -60 -80

1.3 Margins

IONS's Gross Margin of 98.78% is amongst the best of the industry. IONS outperforms 97.37% of its industry peers.
IONS's Gross Margin has been stable in the last couple of years.
The Profit Margin and Operating Margin are not available for IONS so they could not be analyzed.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM 98.78%
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.08%
GM growth 5Y-0.24%
IONS Yearly Profit, Operating, Gross MarginsIONS Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 50 -50

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3

2. Health

2.1 Basic Checks

IONS does not have a ROIC to compare to the WACC, probably because it is not profitable.
IONS has more shares outstanding than it did 1 year ago.
Compared to 5 years ago, IONS has more shares outstanding
Compared to 1 year ago, IONS has an improved debt to assets ratio.
IONS Yearly Shares OutstandingIONS Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 50M 100M 150M
IONS Yearly Total Debt VS Total AssetsIONS Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 1B 2B 3B

2.2 Solvency

IONS has an Altman-Z score of 2.48. This is not the best score and indicates that IONS is in the grey zone with still only limited risk for bankruptcy at the moment.
IONS has a Altman-Z score of 2.48. This is in the better half of the industry: IONS outperforms 69.23% of its industry peers.
A Debt/Equity ratio of 0.96 indicates that IONS is somewhat dependend on debt financing.
IONS's Debt to Equity ratio of 0.96 is on the low side compared to the rest of the industry. IONS is outperformed by 76.17% of its industry peers.
Industry RankSector Rank
Debt/Equity 0.96
Debt/FCF N/A
Altman-Z 2.48
ROIC/WACCN/A
WACC8.17%
IONS Yearly LT Debt VS Equity VS FCFIONS Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M -500M 1B

2.3 Liquidity

A Current Ratio of 2.79 indicates that IONS has no problem at all paying its short term obligations.
IONS has a worse Current ratio (2.79) than 65.67% of its industry peers.
IONS has a Quick Ratio of 2.78. This indicates that IONS is financially healthy and has no problem in meeting its short term obligations.
With a Quick ratio value of 2.78, IONS is not doing good in the industry: 64.17% of the companies in the same industry are doing better.
Industry RankSector Rank
Current Ratio 2.79
Quick Ratio 2.78
IONS Yearly Current Assets VS Current LiabilitesIONS Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B 1.5B 2B 2.5B

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5

3. Growth

3.1 Past

IONS shows a strong growth in Earnings Per Share. In the last year, the EPS has been growing by 30.74%, which is quite impressive.
The Revenue has grown by 20.41% in the past year. This is a very strong growth!
Measured over the past years, IONS shows a decrease in Revenue. The Revenue has been decreasing by -8.88% on average per year.
EPS 1Y (TTM)30.74%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%15.79%
Revenue 1Y (TTM)20.41%
Revenue growth 3Y-4.54%
Revenue growth 5Y-8.88%
Sales Q2Q%17.16%

3.2 Future

Based on estimates for the next years, IONS will show a very strong growth in Earnings Per Share. The EPS will grow by 27.47% on average per year.
Based on estimates for the next years, IONS will show a very strong growth in Revenue. The Revenue will grow by 31.71% on average per year.
EPS Next Y22.41%
EPS Next 2Y-0.32%
EPS Next 3Y16.11%
EPS Next 5Y27.47%
Revenue Next Year42.98%
Revenue Next 2Y20.96%
Revenue Next 3Y30.21%
Revenue Next 5Y31.71%

3.3 Evolution

The Revenue growth rate is accelerating: in the next years the growth will be better than in the last years.
IONS Yearly Revenue VS EstimatesIONS Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 1B 2B 3B 4B
IONS Yearly EPS VS EstimatesIONS Yearly EPS VS EstimatesYearly EPS VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 0 2 -2 4 6 8

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0

4. Valuation

4.1 Price/Earnings Ratio

IONS reported negative earnings for the last year, which makes the Price/Earnings Ratio negative.
Also next year IONS is expected to report negative earnings again, which makes the also the Forward Price/Earnings Ratio negative.
Industry RankSector Rank
PE N/A
Fwd PE N/A
IONS Price Earnings VS Forward Price EarningsIONS Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 50

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
IONS Per share dataIONS EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 2 -2 4 6

4.3 Compensation for Growth

IONS's earnings are expected to grow with 16.11% in the coming years. This may justify a more expensive valuation.
PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y-0.32%
EPS Next 3Y16.11%

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0

5. Dividend

5.1 Amount

IONS does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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IONIS PHARMACEUTICALS INC

NASDAQ:IONS (11/20/2025, 8:00:02 PM)

After market: 73.85 +0.73 (+1%)

73.12

-0.88 (-1.19%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)10-29 2025-10-29/bmo
Earnings (Next)02-17 2026-02-17/amc
Inst Owners108.22%
Inst Owner Change19.52%
Ins Owners0.73%
Ins Owner Change-7.9%
Market Cap11.65B
Revenue(TTM)966.96M
Net Income(TTM)-256.34M
Analysts82.58
Price Target77.31 (5.73%)
Short Float %8.01%
Short Ratio5.1
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)2
Avg EPS beat(2)147.99%
Min EPS beat(2)36.42%
Max EPS beat(2)259.57%
EPS beat(4)4
Avg EPS beat(4)89.18%
Min EPS beat(4)18.36%
Max EPS beat(4)259.57%
EPS beat(8)8
Avg EPS beat(8)66.23%
EPS beat(12)11
Avg EPS beat(12)44.13%
EPS beat(16)14
Avg EPS beat(16)62.35%
Revenue beat(2)2
Avg Revenue beat(2)33.86%
Min Revenue beat(2)17.57%
Max Revenue beat(2)50.14%
Revenue beat(4)4
Avg Revenue beat(4)33.17%
Min Revenue beat(4)3.26%
Max Revenue beat(4)61.73%
Revenue beat(8)7
Avg Revenue beat(8)31.12%
Revenue beat(12)10
Avg Revenue beat(12)23.51%
Revenue beat(16)13
Avg Revenue beat(16)22.62%
PT rev (1m)3.76%
PT rev (3m)28.28%
EPS NQ rev (1m)0.69%
EPS NQ rev (3m)-5.87%
EPS NY rev (1m)9.26%
EPS NY rev (3m)25.02%
Revenue NQ rev (1m)6.86%
Revenue NQ rev (3m)2.76%
Revenue NY rev (1m)3.18%
Revenue NY rev (3m)17.17%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S 12.05
P/FCF N/A
P/OCF N/A
P/B 18.86
P/tB 18.86
EV/EBITDA N/A
EPS(TTM)-1.69
EYN/A
EPS(NY)-3.06
Fwd EYN/A
FCF(TTM)-1.9
FCFYN/A
OCF(TTM)-1.55
OCFYN/A
SpS6.07
BVpS3.88
TBVpS3.88
PEG (NY)N/A
PEG (5Y)N/A
Graham NumberN/A
Profitability
Industry RankSector Rank
ROA -8.45%
ROE -41.48%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM 98.78%
FCFM N/A
ROA(3y)-12.67%
ROA(5y)-11.54%
ROE(3y)-72.98%
ROE(5y)-56.49%
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexgc growth 3YN/A
ROICexgc growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.08%
GM growth 5Y-0.24%
F-Score5
Asset Turnover0.32
Health
Industry RankSector Rank
Debt/Equity 0.96
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 1473.37%
Cap/Sales 5.76%
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 2.79
Quick Ratio 2.78
Altman-Z 2.48
F-Score5
WACC8.17%
ROIC/WACCN/A
Cap/Depr(3y)219.39%
Cap/Depr(5y)190.33%
Cap/Sales(3y)4.04%
Cap/Sales(5y)3.68%
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)30.74%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%15.79%
EPS Next Y22.41%
EPS Next 2Y-0.32%
EPS Next 3Y16.11%
EPS Next 5Y27.47%
Revenue 1Y (TTM)20.41%
Revenue growth 3Y-4.54%
Revenue growth 5Y-8.88%
Sales Q2Q%17.16%
Revenue Next Year42.98%
Revenue Next 2Y20.96%
Revenue Next 3Y30.21%
Revenue Next 5Y31.71%
EBIT growth 1Y24.52%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year31.51%
EBIT Next 3Y14.11%
EBIT Next 5YN/A
FCF growth 1Y46.84%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y54.31%
OCF growth 3YN/A
OCF growth 5YN/A

IONIS PHARMACEUTICALS INC / IONS FAQ

What is the fundamental rating for IONS stock?

ChartMill assigns a fundamental rating of 3 / 10 to IONS.


What is the valuation status for IONS stock?

ChartMill assigns a valuation rating of 0 / 10 to IONIS PHARMACEUTICALS INC (IONS). This can be considered as Overvalued.


What is the profitability of IONS stock?

IONIS PHARMACEUTICALS INC (IONS) has a profitability rating of 3 / 10.


How financially healthy is IONIS PHARMACEUTICALS INC?

The financial health rating of IONIS PHARMACEUTICALS INC (IONS) is 3 / 10.