IONIS PHARMACEUTICALS INC (IONS) Earnings History & Surprises
NASDAQ:IONS • US4622221004
76.6 USD
+1.24 (+1.65%)
Last: Mar 10, 2026, 02:56 PM
Past quarterly earnings results for IONIS PHARMACEUTICALS INC (IONS), including EPS and revenue actuals, analyst estimates, and surprise percentages. This page focuses on historical performance (not forecasts).
Earnings Snapshot
Next Earnings Date
Release DateApr 28, 2026
PeriodQ1 / 2026
EPS Estimate-$0.90
Revenue Estimate199.47M
Last Reported
Release DateFeb 25, 2026
PeriodQ4 / 2025
EPS Reported-$1.41
EPS Surprise -4.63%
Revenue Surprise 27.50%
Beat Rate
88%
EPS and Revenuebeats vs estimates
Quarterly Earnings Results
EPS & Revenue History (USD)
Actual vs estimated values, surprises, q2q growth and acceleration numbers for recent quarters.
| Quarter | EPS | EPS Est | EPS Surprise | EPS Q2Q | Revenue | Revenue Est | Revenue Surprise | Revenue Q2Q |
|---|---|---|---|---|---|---|---|---|
| Q4 2025 | -1.41 | -1.35 | -4.63% | -113.64% | 203M | 159.22M | 27.50% | -10.57% |
| Q3 2025 | -0.80 | -1.26 | 36.42% | 15.79% | 157M | 133.54M | 17.57% | 17.16% |
| Q2 2025 | 0.70 | -0.44 | 259.57% | 255.56% | 452.049M | 301.08M | 50.14% | 100.69% |
| Q1 2025 | -0.93 | -1.14 | 18.36% | 5.10% | 132M | 127.83M | 3.26% | 10.92% |
| Q4 2024 | -0.66 | -1.15 | 42.39% | -1,000.00% | 227M | 140.36M | 61.73% | -30.15% |
| Q3 2024 | -0.95 | -1.18 | 19.50% | 7.77% | 134M | 132.73M | 0.96% | -6.94% |
| Q2 2024 | -0.45 | -0.94 | 52.10% | 25.00% | 225.25M | 153.07M | 47.15% | 19.81% |
| Q1 2024 | -0.98 | -1.07 | 8.61% | -12.64% | 119M | 138.65M | -14.17% | -9.16% |
| Q4 2023 | -0.06 | -0.85 | 92.92% | 95.59% | 325M | 178.25M | 82.33% | 113.96% |
| Q3 2023 | -1.03 | -1.06 | 2.99% | -212.12% | 144M | 135.56M | 6.23% | -9.89% |
| Q2 2023 | -0.60 | -0.92 | 34.77% | 18.92% | 188M | 141.6M | 32.77% | 40.51% |
| Q1 2023 | -0.87 | -0.93 | 6.36% | -89.13% | 131M | 130.68M | 0.24% | -7.68% |
| Q4 2022 | -1.36 | -0.94 | -44.37% | -196.45% | 151.9M | 161.82M | -6.13% | -65.48% |
| Q3 2022 | -0.33 | -0.76 | 56.43% | 43.10% | 159.8M | 146.77M | 8.88% | 20.06% |
| Q2 2022 | -0.74 | -0.64 | -16.37% | -29.82% | 133.8M | 143.33M | -6.65% | 6.36% |
| Q1 2022 | -0.46 | -0.73 | 36.60% | 28.13% | 141.9M | 127.72M | 11.10% | 27.15% |
| Q4 2021 | 1.41 | 0.29 | 391.36% | 220.45% | 440M | 264.33M | 66.46% | 51.57% |
| Q3 2021 | -0.58 | -0.54 | -8.24% | -163.64% | 133.1M | 161.55M | -17.61% | -16.86% |
| Q2 2021 | -0.57 | -0.61 | 6.57% | -147.83% | 125.8M | 139.04M | -9.52% | -13.54% |
| Q1 2021 | -0.64 | -0.54 | -19.44% | -82.86% | 111.6M | 131.16M | -14.91% | -16.34% |
| Q4 2020 | 0.44 | 0.29 | 52.87% | - | 290.3M | 279.97M | 3.69% | - |
| Q3 2020 | -0.22 | -0.10 | -127.88% | - | 160.1M | 185.78M | -13.82% | - |
| Q2 2020 | -0.23 | -0.28 | 18.04% | - | 145.5M | 151.85M | -4.18% | - |
| Q1 2020 | -0.35 | -0.13 | -171.77% | - | 133.4M | 164.35M | -18.83% | - |
Notes
- EPS and Revenue values are non-GAAP when available, otherwise GAAP.
- Surprise % is (Actual - Estimate) / |Estimate|. Green indicates positive surprise, red negative.
- Q2Q % is quarter-over-quarter growth. Green indicates growth, red indicates decline.
- Green right border indicates acceleration for sales or earnings growth. Acceleration is the case when the current Q2Q is above the previous Q2Q.
Earnings Q2Q Performance Trends
EPS Historical Q2Q growth and Acceleration
Revenue Historical Q2Q growth and Acceleration
Surprise distribution (Last 4 Quarters)
EPS beat statistics
EPS beat (4)
3
Average EPS beat (4)
77.43%
Max EPS beat (4)
259.57%
Min EPS beat (4)
-4.63%
Revenue beat statistics
Revenue beat (4)
4
Average Revenue beat (4)
24.62%
Max Revenue beat (4)
50.14%
Min Revenue beat (4)
3.26%
Analysis
In the last 4 quarters, IONS has beaten EPS estimates in 3 out of 4 releases
IONS has consistently beaten revenue estimates in all past 4 earnings releases
In the last 4 quarters, IONS has beaten the EPS estimates by 77.4% on average.
In the last 4 quarters, IONS has beaten the revenue estimates by 24.6% on average.
IONIS PHARMACEUTICALS INC / IONS Earnings FAQ
What is the most recent earnings date for IONS stock?
IONIS PHARMACEUTICALS INC (IONS) last reported earnings on 2/25/2026.
Did IONIS PHARMACEUTICALS INC (IONS) beat earnings estimates last quarter?
IONIS PHARMACEUTICALS INC (IONS) missed EPS estimates and beat revenue estimates in the most recent quarter.
What percentage of the time does IONS stock beat earnings estimates?
In the last 4 quarters, IONIS PHARMACEUTICALS INC (IONS) has beaten EPS estimates in 3 out of 4 releases.