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UPSTREAM BIO INC (UPB) Stock Fundamental Analysis

NASDAQ:UPB - Nasdaq - US91678A1079 - Common Stock - Currency: USD

18.93  +0.31 (+1.66%)

After market: 18.93 0 (0%)

Fundamental Rating

3

UPB gets a fundamental rating of 3 out of 10. The analysis compared the fundamentals against 550 industry peers in the Biotechnology industry. UPB has a great financial health rating, but its profitability evaluates not so good. UPB does not seem to be growing, but still is valued expensively.


Dividend Valuation Growth Profitability Health

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1

1. Profitability

1.1 Basic Checks

UPB had negative earnings in the past year.
UPB Yearly Net Income VS EBIT VS OCF VS FCFUPB Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2022 2023 2024 -20M -40M -60M

1.2 Ratios

UPB has a Return On Assets of -22.73%. This is in the better half of the industry: UPB outperforms 76.36% of its industry peers.
UPB's Return On Equity of -23.26% is amongst the best of the industry. UPB outperforms 82.00% of its industry peers.
Industry RankSector Rank
ROA -22.73%
ROE -23.26%
ROIC N/A
ROA(3y)-59.22%
ROA(5y)N/A
ROE(3y)-136.56%
ROE(5y)N/A
ROIC(3y)N/A
ROIC(5y)N/A
UPB Yearly ROA, ROE, ROICUPB Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2022 2023 2024 -100 -200 -300

1.3 Margins

UPB does not have Profit Margin and Operating Margin and Gross Margin available, so we won't be analyzing them here.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM N/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
UPB Yearly Profit, Operating, Gross MarginsUPB Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2022 2023 2024 -1K -2K -3K

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2. Health

2.1 Basic Checks

UPB does not have a ROIC to compare to the WACC, probably because it is not profitable.
The number of shares outstanding for UPB has been increased compared to 1 year ago.
UPB has no outstanding debt. Therefor its Debt/Equity and Debt/FCF ratios are 0 and belong to the best of the industry.
UPB Yearly Shares OutstandingUPB Yearly Shares OutstandingYearly Shares Outstanding 2022 2023 2024 10M 20M 30M 40M 50M
UPB Yearly Total Debt VS Total AssetsUPB Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2022 2023 2024 100M 200M 300M 400M

2.2 Solvency

UPB has an Altman-Z score of 56.62. This indicates that UPB is financially healthy and has little risk of bankruptcy at the moment.
The Altman-Z score of UPB (56.62) is better than 98.73% of its industry peers.
UPB has no outstanding debt. Therefor its Debt/Equity and Debt/FCF ratios are 0 and belong to the best of the industry.
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Altman-Z 56.62
ROIC/WACCN/A
WACC9.85%
UPB Yearly LT Debt VS Equity VS FCFUPB Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2022 2023 2024 0 100M 200M 300M 400M

2.3 Liquidity

UPB has a Current Ratio of 47.43. This indicates that UPB is financially healthy and has no problem in meeting its short term obligations.
UPB has a Current ratio of 47.43. This is amongst the best in the industry. UPB outperforms 99.27% of its industry peers.
UPB has a Quick Ratio of 47.43. This indicates that UPB is financially healthy and has no problem in meeting its short term obligations.
With an excellent Quick ratio value of 47.43, UPB belongs to the best of the industry, outperforming 99.27% of the companies in the same industry.
Industry RankSector Rank
Current Ratio 47.43
Quick Ratio 47.43
UPB Yearly Current Assets VS Current LiabilitesUPB Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2022 2023 2024 100M 200M 300M 400M

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1

3. Growth

3.1 Past

The earnings per share for UPB have decreased strongly by -99.70% in the last year.
Looking at the last year, UPB shows a decrease in Revenue. The Revenue has decreased by -0.42% in the last year.
EPS 1Y (TTM)-99.7%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%N/A
Revenue 1Y (TTM)-0.42%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A

3.2 Future

The Earnings Per Share is expected to grow by 18.56% on average over the next years. This is quite good.
The Revenue is expected to decrease by -11.32% on average over the next years. This is quite bad
EPS Next Y68.01%
EPS Next 2Y27.91%
EPS Next 3Y18.56%
EPS Next 5YN/A
Revenue Next Year-21.46%
Revenue Next 2Y-21.6%
Revenue Next 3Y-11.32%
Revenue Next 5YN/A

3.3 Evolution

UPB Yearly Revenue VS EstimatesUPB Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2022 2023 2024 2025 2026 2027 500K 1M 1.5M 2M
UPB Yearly EPS VS EstimatesUPB Yearly EPS VS EstimatesYearly EPS VS Estimates 2024 2025 2026 2027 -2 -4 -6 -8

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0

4. Valuation

4.1 Price/Earnings Ratio

UPB reported negative earnings for the last year, which makes the Price/Earnings Ratio negative.
Also next year UPB is expected to report negative earnings again, which makes the also the Forward Price/Earnings Ratio negative.
Industry RankSector Rank
PE N/A
Fwd PE N/A
UPB Price Earnings VS Forward Price EarningsUPB Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
UPB Per share dataUPB EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 2 -2 4 6 8

4.3 Compensation for Growth

UPB's earnings are expected to grow with 18.56% in the coming years. This may justify a more expensive valuation.
PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y27.91%
EPS Next 3Y18.56%

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0

5. Dividend

5.1 Amount

UPB does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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UPSTREAM BIO INC

NASDAQ:UPB (8/15/2025, 8:00:01 PM)

After market: 18.93 0 (0%)

18.93

+0.31 (+1.66%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)08-06 2025-08-06/bmo
Earnings (Next)11-05 2025-11-05
Inst Owners78.74%
Inst Owner Change0.68%
Ins Owners0.05%
Ins Owner Change0%
Market Cap1.02B
Analysts82.5
Price Target76.5 (304.12%)
Short Float %9.42%
Short Ratio8.44
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)0
Avg EPS beat(2)-92.62%
Min EPS beat(2)-181.12%
Max EPS beat(2)-4.11%
EPS beat(4)N/A
Avg EPS beat(4)N/A
Min EPS beat(4)N/A
Max EPS beat(4)N/A
EPS beat(8)N/A
Avg EPS beat(8)N/A
EPS beat(12)N/A
Avg EPS beat(12)N/A
EPS beat(16)N/A
Avg EPS beat(16)N/A
Revenue beat(2)2
Avg Revenue beat(2)64.38%
Min Revenue beat(2)57.64%
Max Revenue beat(2)71.11%
Revenue beat(4)N/A
Avg Revenue beat(4)N/A
Min Revenue beat(4)N/A
Max Revenue beat(4)N/A
Revenue beat(8)N/A
Avg Revenue beat(8)N/A
Revenue beat(12)N/A
Avg Revenue beat(12)N/A
Revenue beat(16)N/A
Avg Revenue beat(16)N/A
PT rev (1m)0%
PT rev (3m)32.74%
EPS NQ rev (1m)-0.41%
EPS NQ rev (3m)-13.43%
EPS NY rev (1m)0%
EPS NY rev (3m)-6.98%
Revenue NQ rev (1m)0%
Revenue NQ rev (3m)-9.93%
Revenue NY rev (1m)0%
Revenue NY rev (3m)16.99%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S 346.81
P/FCF N/A
P/OCF N/A
P/B 2.29
P/tB 2.29
EV/EBITDA N/A
EPS(TTM)-2
EYN/A
EPS(NY)-2.95
Fwd EYN/A
FCF(TTM)N/A
FCFYN/A
OCF(TTM)N/A
OCFYN/A
SpS0.05
BVpS8.28
TBVpS8.28
PEG (NY)N/A
PEG (5Y)N/A
Profitability
Industry RankSector Rank
ROA -22.73%
ROE -23.26%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM N/A
FCFM N/A
ROA(3y)-59.22%
ROA(5y)N/A
ROE(3y)-136.56%
ROE(5y)N/A
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexcg growth 3YN/A
ROICexcg growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
F-ScoreN/A
Asset Turnover0.01
Health
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr N/A
Cap/Sales N/A
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 47.43
Quick Ratio 47.43
Altman-Z 56.62
F-ScoreN/A
WACC9.85%
ROIC/WACCN/A
Cap/Depr(3y)661.86%
Cap/Depr(5y)N/A
Cap/Sales(3y)11.46%
Cap/Sales(5y)N/A
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)-99.7%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%N/A
EPS Next Y68.01%
EPS Next 2Y27.91%
EPS Next 3Y18.56%
EPS Next 5YN/A
Revenue 1Y (TTM)-0.42%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A
Revenue Next Year-21.46%
Revenue Next 2Y-21.6%
Revenue Next 3Y-11.32%
Revenue Next 5YN/A
EBIT growth 1Y-93.86%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year-91.2%
EBIT Next 3Y-36.84%
EBIT Next 5YN/A
FCF growth 1Y-56.77%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-56.02%
OCF growth 3YN/A
OCF growth 5YN/A