UPSTREAM BIO INC (UPB) Stock Price, Forecast & Analysis

NASDAQ:UPB • US91678A1079

12.8 USD
-1.89 (-12.87%)
At close: Feb 12, 2026
12.54 USD
-0.26 (-2.03%)
After Hours: 2/12/2026, 8:19:37 PM

UPB Key Statistics, Chart & Performance

Key Statistics
Market Cap691.71M
Revenue(TTM)2.80M
Net Income(TTM)-122.77M
Shares54.04M
Float40.36M
52 Week High33.68
52 Week Low5.14
Yearly DividendN/A
Dividend Yield0%
EPS(TTM)-3.47
PEN/A
Fwd PEN/A
Earnings (Next)03-10
IPO2024-10-11
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology
UPB short term performance overview.The bars show the price performance of UPB in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months -20 -40 -60

UPB long term performance overview.The bars show the price performance of UPB in the last 1, 2 and 3 years. 1 year 2 years 3 years 20 40 60

The current stock price of UPB is 12.8 USD. In the past month the price decreased by -60.37%. In the past year, price increased by 68.42%.

UPSTREAM BIO INC / UPB Daily stock chart

UPB Technical Analysis

ChartMill assigns a technical rating of 1 / 10 to UPB. When comparing the yearly performance of all stocks, UPB turns out to be only a medium performer in the overall market: it outperformed 67.93% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating
UPB Full Technical Analysis Report

UPB Fundamental Analysis

ChartMill assigns a fundamental rating of 3 / 10 to UPB. UPB has a great financial health rating, but its profitability evaluates not so good.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend
UPB Full Fundamental Analysis Report

UPB Financial Highlights

Over the last trailing twelve months UPB reported a non-GAAP Earnings per Share(EPS) of -3.47. The EPS decreased by -99.7% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -31.38%
ROE -32.43%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%90.95%
Sales Q2Q%12.52%
EPS 1Y (TTM)-99.7%
Revenue 1Y (TTM)-0.42%
UPB financials

UPB Forecast & Estimates

12 analysts have analysed UPB and the average price target is 49.47 USD. This implies a price increase of 286.48% is expected in the next year compared to the current price of 12.8.

For the next year, analysts expect an EPS growth of 67.9% and a revenue growth 25.51% for UPB


Analysts
Analysts81.67
Price Target49.47 (286.48%)
EPS Next Y67.9%
Revenue Next Year25.51%
UPB Analyst EstimatesUPB Analyst Ratings

UPB Ownership

Ownership
Inst Owners76.89%
Ins Owners0.05%
Short Float %8.55%
Short Ratio5.8
UPB Ownership

UPB Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
SymbolCompany NameTechnical RatingFundamental RatingFPEMarket Cap
ABBV ABBVIE INC15.67390.397B
AMGN AMGEN INC16.25197.396B
GILD GILEAD SCIENCES INC17.02193.298B
VRTX VERTEX PHARMACEUTICALS INC22.81117.026B
REGN REGENERON PHARMACEUTICALS16.8781.87B
ALNY ALNYLAM PHARMACEUTICALS INC46.0542.576B
INSM INSMED INC N/A31.656B
NTRA NATERA INC N/A29.322B
BIIB BIOGEN INC12.8528.06B
UTHR UNITED THERAPEUTICS CORP16.1620.49B

About UPB

Company Profile

UPB logo image Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The company is headquartered in Waltham, Massachusetts and currently employs 52 full-time employees. The company went IPO on 2024-10-11. The firm is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The company has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.

Company Info

UPSTREAM BIO INC

890 Winter Street, Suite 200

Waltham MASSACHUSETTS US

Employees: 52

UPB Company Website

Phone: 17812082466

UPSTREAM BIO INC / UPB FAQ

What does UPB do?

Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The company is headquartered in Waltham, Massachusetts and currently employs 52 full-time employees. The company went IPO on 2024-10-11. The firm is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The company has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.


What is the current price of UPB stock?

The current stock price of UPB is 12.8 USD. The price decreased by -12.87% in the last trading session.


What is the dividend status of UPSTREAM BIO INC?

UPB does not pay a dividend.


How is the ChartMill rating for UPSTREAM BIO INC?

UPB has a ChartMill Technical rating of 1 out of 10 and a ChartMill Fundamental rating of 3 out of 10.


What is the analyst forecast for UPB stock?

12 analysts have analysed UPB and the average price target is 49.47 USD. This implies a price increase of 286.48% is expected in the next year compared to the current price of 12.8.


Is UPSTREAM BIO INC (UPB) stock a good buy?

This depends on your investment goals. Check the Technical and Fundamental Analysis tabs for insights on UPB.