Logo image of UPB

UPSTREAM BIO INC (UPB) Stock Overview

NASDAQ:UPB - US91678A1079 - Common Stock

19.97 USD
+0.29 (+1.47%)
Last: 9/5/2025, 8:00:02 PM
19.58 USD
-0.39 (-1.95%)
After Hours: 9/5/2025, 8:00:02 PM

UPB Key Statistics, Chart & Performance

Key Statistics
52 Week HighN/A
52 Week LowN/A
Market Cap1.08B
Shares53.91M
Float40.23M
Yearly DividendN/A
Dividend YieldN/A
EPS(TTM)-9.8
PEN/A
Fwd PEN/A
Earnings (Next)11-05 2025-11-05
IPO10-11 2024-10-11
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


UPB short term performance overview.The bars show the price performance of UPB in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 20 40 60 80 100

UPB long term performance overview.The bars show the price performance of UPB in the last 1, 2 and 3 years. 1 year 2 years 3 years

The current stock price of UPB is 19.97 USD. In the past month the price increased by 26.07%.

UPSTREAM BIO INC / UPB Daily stock chart

UPB Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
Symbol
Company Name
TA
FA
PE
Market Cap
ABBV ABBVIE INC 20.07 375.50B
AMGN AMGEN INC 13.01 152.70B
GILD GILEAD SCIENCES INC 14.86 142.76B
VRTX VERTEX PHARMACEUTICALS INC 23.38 101.56B
REGN REGENERON PHARMACEUTICALS 12.56 60.77B
ALNY ALNYLAM PHARMACEUTICALS INC N/A 59.25B
ARGX ARGENX SE - ADR 80.99 45.95B
ONC BEONE MEDICINES LTD-ADR 5.99 40.63B
INSM INSMED INC N/A 30.67B
BNTX BIONTECH SE-ADR N/A 27.03B
NTRA NATERA INC N/A 23.06B
BIIB BIOGEN INC 8.79 20.62B

About UPB

Company Profile

UPB logo image Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The company is headquartered in Waltham, Massachusetts and currently employs 52 full-time employees. The company went IPO on 2024-10-11. The firm is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The company has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.

Company Info

UPSTREAM BIO INC

890 Winter Street, Suite 200

Waltham MASSACHUSETTS US

Employees: 52

UPB Company Website

Phone: 17812082466

UPSTREAM BIO INC / UPB FAQ

What is the stock price of UPSTREAM BIO INC today?

The current stock price of UPB is 19.97 USD. The price increased by 1.47% in the last trading session.


What is the ticker symbol for UPSTREAM BIO INC stock?

The exchange symbol of UPSTREAM BIO INC is UPB and it is listed on the Nasdaq exchange.


On which exchange is UPB stock listed?

UPB stock is listed on the Nasdaq exchange.


What is the price forecast or stock price prediction for UPSTREAM BIO INC stock?

8 analysts have analysed UPB and the average price target is 76.5 USD. This implies a price increase of 283.07% is expected in the next year compared to the current price of 19.97. Check the UPSTREAM BIO INC stock analysts ratings, price target forecast and up-and down grades for more detailed information.


What is UPSTREAM BIO INC worth?

UPSTREAM BIO INC (UPB) has a market capitalization of 1.08B USD. This makes UPB a Small Cap stock.


How many employees does UPSTREAM BIO INC have?

UPSTREAM BIO INC (UPB) currently has 52 employees.


What are the support and resistance levels for UPSTREAM BIO INC (UPB) stock?

UPSTREAM BIO INC (UPB) has a support level at 12.88 and a resistance level at 19.98. Check the full technical report for a detailed analysis of UPB support and resistance levels.


Is UPSTREAM BIO INC (UPB) expected to grow?

The Revenue of UPSTREAM BIO INC (UPB) is expected to grow by 21.55% in the next year. Check the estimates tab for more information on the UPB EPS, Sales, EBIT and EBITDA future analyst estimates.


Should I buy UPSTREAM BIO INC (UPB) stock?

There is no straightforward answer here. It depends on your investment strategy as different types of investors will look at different aspects. In any case it is important to make an informed decision and these pages can help you forming an opinion:


Does UPSTREAM BIO INC (UPB) stock pay dividends?

UPB does not pay a dividend.


When does UPSTREAM BIO INC (UPB) report earnings?

UPSTREAM BIO INC (UPB) will report earnings on 2025-11-05.


What is the Price/Earnings (PE) ratio of UPSTREAM BIO INC (UPB)?

UPSTREAM BIO INC (UPB) does not have a PE ratio as the earnings reported over the last twelve months were negative (-9.8).


What is the Short Interest ratio of UPSTREAM BIO INC (UPB) stock?

The outstanding short interest for UPSTREAM BIO INC (UPB) is 7.86% of its float. Check the ownership tab for more information on the UPB short interest.


UPB Technical Analysis

ChartMill assigns a technical rating of 7 / 10 to UPB.


Chartmill TA Rating
Chartmill Setup Rating

UPB Fundamental Analysis

ChartMill assigns a fundamental rating of 3 / 10 to UPB. While UPB has a great health rating, there are worries on its profitability.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

UPB Financial Highlights

Over the last trailing twelve months UPB reported a non-GAAP Earnings per Share(EPS) of -9.8. The EPS decreased by -99.7% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -26.17%
ROE -26.93%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%-13.67%
Sales Q2Q%-18.52%
EPS 1Y (TTM)-99.7%
Revenue 1Y (TTM)-0.42%

UPB Forecast & Estimates

8 analysts have analysed UPB and the average price target is 76.5 USD. This implies a price increase of 283.07% is expected in the next year compared to the current price of 19.97.

For the next year, analysts expect an EPS growth of 65.26% and a revenue growth 21.55% for UPB


Analysts
Analysts82.5
Price Target76.5 (283.07%)
EPS Next Y65.26%
Revenue Next Year21.55%

UPB Ownership

Ownership
Inst Owners78.74%
Ins Owners0.05%
Short Float %7.86%
Short Ratio6.56