Logo image of UPB

UPSTREAM BIO INC (UPB) Stock Price, Forecast & Analysis

USA - Nasdaq - NASDAQ:UPB - US91678A1079 - Common Stock

28.53 USD
-0.3 (-1.04%)
Last: 11/26/2025, 1:48:49 PM

UPB Key Statistics, Chart & Performance

Key Statistics
Market Cap1.54B
Revenue(TTM)2.80M
Net Income(TTM)-122.77M
Shares53.91M
Float40.23M
52 Week High29.29
52 Week Low5.14
Yearly DividendN/A
Dividend YieldN/A
EPS(TTM)-3.47
PEN/A
Fwd PEN/A
Earnings (Next)03-10 2026-03-10
IPO2024-10-11
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


UPB short term performance overview.The bars show the price performance of UPB in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 50 100 150 200

UPB long term performance overview.The bars show the price performance of UPB in the last 1, 2 and 3 years. 1 year 2 years 3 years 10 20 30

The current stock price of UPB is 28.53 USD. In the past month the price increased by 16.06%. In the past year, price increased by 31.82%.

UPSTREAM BIO INC / UPB Daily stock chart

UPB Latest News, Press Relases and Analysis

UPB Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
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TA
FA
PE
Market Cap
ABBV ABBVIE INC 24.07 401.89B
AMGN AMGEN INC 15.76 185.57B
GILD GILEAD SCIENCES INC 15.61 158.65B
VRTX VERTEX PHARMACEUTICALS INC 24.8 110.39B
REGN REGENERON PHARMACEUTICALS 17.48 83.37B
ALNY ALNYLAM PHARMACEUTICALS INC 871.84 58.28B
INSM INSMED INC N/A 43.42B
NTRA NATERA INC N/A 32.64B
BIIB BIOGEN INC 10.91 26.77B
UTHR UNITED THERAPEUTICS CORP 18.58 22.18B
INCY INCYTE CORP 16.57 20.77B
EXAS EXACT SCIENCES CORP N/A 19.22B

About UPB

Company Profile

UPB logo image Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The company is headquartered in Waltham, Massachusetts and currently employs 52 full-time employees. The company went IPO on 2024-10-11. The firm is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The company has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.

Company Info

UPSTREAM BIO INC

890 Winter Street, Suite 200

Waltham MASSACHUSETTS US

Employees: 52

UPB Company Website

Phone: 17812082466

UPSTREAM BIO INC / UPB FAQ

What does UPB do?

Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The company is headquartered in Waltham, Massachusetts and currently employs 52 full-time employees. The company went IPO on 2024-10-11. The firm is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The company has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.


Can you provide the latest stock price for UPSTREAM BIO INC?

The current stock price of UPB is 28.53 USD. The price decreased by -1.04% in the last trading session.


Does UPB stock pay dividends?

UPB does not pay a dividend.


What is the ChartMill technical and fundamental rating of UPB stock?

UPB has a ChartMill Technical rating of 10 out of 10 and a ChartMill Fundamental rating of 3 out of 10.


On which exchange is UPB stock listed?

UPB stock is listed on the Nasdaq exchange.


What is the next earnings date for UPB stock?

UPSTREAM BIO INC (UPB) will report earnings on 2026-03-10.


Can you provide the short interest for UPB stock?

The outstanding short interest for UPSTREAM BIO INC (UPB) is 7.28% of its float.


UPB Technical Analysis

ChartMill assigns a technical rating of 10 / 10 to UPB. When comparing the yearly performance of all stocks, UPB is one of the better performing stocks in the market, outperforming 93.81% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating

UPB Fundamental Analysis

ChartMill assigns a fundamental rating of 3 / 10 to UPB. UPB has a great financial health rating, but its profitability evaluates not so good.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

UPB Financial Highlights

Over the last trailing twelve months UPB reported a non-GAAP Earnings per Share(EPS) of -3.47. The EPS decreased by -99.7% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -31.38%
ROE -32.43%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%90.95%
Sales Q2Q%12.52%
EPS 1Y (TTM)-99.7%
Revenue 1Y (TTM)-0.42%

UPB Forecast & Estimates

9 analysts have analysed UPB and the average price target is 62.22 USD. This implies a price increase of 118.09% is expected in the next year compared to the current price of 28.53.

For the next year, analysts expect an EPS growth of 64.81% and a revenue growth 10.82% for UPB


Analysts
Analysts82.22
Price Target62.22 (118.09%)
EPS Next Y64.81%
Revenue Next Year10.82%

UPB Ownership

Ownership
Inst Owners79.85%
Ins Owners0.05%
Short Float %7.28%
Short Ratio7.13