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KARYOPHARM THERAPEUTICS INC (KPTI) Stock Fundamental Analysis

NASDAQ:KPTI - Nasdaq - US48576U2050 - Common Stock - Currency: USD

4.38  -0.06 (-1.35%)

After market: 4.38 0 (0%)

Fundamental Rating

2

KPTI gets a fundamental rating of 2 out of 10. The analysis compared the fundamentals against 557 industry peers in the Biotechnology industry. KPTI may be in some trouble as it scores bad on both profitability and health. KPTI is valied quite expensively at the moment, while it does show a decent growth rate.


Dividend Valuation Growth Profitability Health

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1

1. Profitability

1.1 Basic Checks

KPTI had negative earnings in the past year.
KPTI had a negative operating cash flow in the past year.
KPTI had negative earnings in each of the past 5 years.
In the past 5 years KPTI always reported negative operating cash flow.
KPTI Yearly Net Income VS EBIT VS OCF VS FCFKPTI Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 -50M -100M -150M

1.2 Ratios

With a Return On Assets value of -48.96%, KPTI perfoms like the industry average, outperforming 49.73% of the companies in the same industry.
Industry RankSector Rank
ROA -48.96%
ROE N/A
ROIC N/A
ROA(3y)-50.71%
ROA(5y)-51.1%
ROE(3y)N/A
ROE(5y)N/A
ROIC(3y)N/A
ROIC(5y)N/A
KPTI Yearly ROA, ROE, ROICKPTI Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 200 -200 400 -400 600 800

1.3 Margins

The Gross Margin of KPTI (96.20%) is better than 95.69% of its industry peers.
In the last couple of years the Gross Margin of KPTI has remained more or less at the same level.
KPTI does not have Profit Margin and Operating Margin available, so we won't be analyzing them here.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM 96.2%
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.86%
GM growth 5Y0.37%
KPTI Yearly Profit, Operating, Gross MarginsKPTI Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 -10K -20K -30K -40K -50K

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1

2. Health

2.1 Basic Checks

KPTI does not have a ROIC to compare to the WACC, probably because it is not profitable.
Compared to 1 year ago, KPTI has more shares outstanding
The number of shares outstanding for KPTI has been increased compared to 5 years ago.
Compared to 1 year ago, KPTI has a worse debt to assets ratio.
KPTI Yearly Shares OutstandingKPTI Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2M 4M 6M 8M
KPTI Yearly Total Debt VS Total AssetsKPTI Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 100M 200M 300M

2.2 Solvency

KPTI has an Altman-Z score of -19.01. This is a bad value and indicates that KPTI is not financially healthy and even has some risk of bankruptcy.
KPTI has a Altman-Z score of -19.01. This is amonst the worse of the industry: KPTI underperforms 84.74% of its industry peers.
Industry RankSector Rank
Debt/Equity N/A
Debt/FCF N/A
Altman-Z -19.01
ROIC/WACCN/A
WACC6.12%
KPTI Yearly LT Debt VS Equity VS FCFKPTI Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 100M -100M 200M 300M

2.3 Liquidity

KPTI has a Current Ratio of 1.33. This is a normal value and indicates that KPTI is financially healthy and should not expect problems in meeting its short term obligations.
KPTI's Current ratio of 1.33 is on the low side compared to the rest of the industry. KPTI is outperformed by 84.38% of its industry peers.
KPTI has a Quick Ratio of 1.28. This is a normal value and indicates that KPTI is financially healthy and should not expect problems in meeting its short term obligations.
Looking at the Quick ratio, with a value of 1.28, KPTI is doing worse than 84.02% of the companies in the same industry.
Industry RankSector Rank
Current Ratio 1.33
Quick Ratio 1.28
KPTI Yearly Current Assets VS Current LiabilitesKPTI Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 100M 200M 300M

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6

3. Growth

3.1 Past

KPTI shows a strong growth in Earnings Per Share. In the last year, the EPS has been growing by 57.90%, which is quite impressive.
Looking at the last year, KPTI shows a small growth in Revenue. The Revenue has grown by 1.18% in the last year.
KPTI shows a strong growth in Revenue. Measured over the last years, the Revenue has been growing by 28.85% yearly.
EPS 1Y (TTM)57.9%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%42.29%
Revenue 1Y (TTM)1.18%
Revenue growth 3Y-11.54%
Revenue growth 5Y28.85%
Sales Q2Q%-9.39%

3.2 Future

The Earnings Per Share is expected to grow by 15.54% on average over the next years. This is quite good.
The Revenue is expected to grow by 23.31% on average over the next years. This is a very strong growth
EPS Next Y-45.56%
EPS Next 2Y0.24%
EPS Next 3Y9.8%
EPS Next 5Y15.54%
Revenue Next Year-2.58%
Revenue Next 2Y5.3%
Revenue Next 3Y14.14%
Revenue Next 5Y23.31%

3.3 Evolution

The Revenue growth rate is stable: in the next years the growth will be about the same than in the last years.
KPTI Yearly Revenue VS EstimatesKPTI Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 200M 400M 600M
KPTI Yearly EPS VS EstimatesKPTI Yearly EPS VS EstimatesYearly EPS VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 0 -10 -20 -30 -40 -50

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0

4. Valuation

4.1 Price/Earnings Ratio

The Price/Earnings Ratio is negative for KPTI. In the last year negative earnings were reported.
Also next year KPTI is expected to report negative earnings again, which makes the also the Forward Price/Earnings Ratio negative.
Industry RankSector Rank
PE N/A
Fwd PE N/A
KPTI Price Earnings VS Forward Price EarningsKPTI Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
KPTI Per share dataKPTI EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 10 -10 -20

4.3 Compensation for Growth

PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y0.24%
EPS Next 3Y9.8%

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0

5. Dividend

5.1 Amount

No dividends for KPTI!.
Industry RankSector Rank
Dividend Yield N/A

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KARYOPHARM THERAPEUTICS INC

NASDAQ:KPTI (6/20/2025, 8:00:02 PM)

After market: 4.38 0 (0%)

4.38

-0.06 (-1.35%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)05-12 2025-05-12/amc
Earnings (Next)08-04 2025-08-04/bmo
Inst Owners42.62%
Inst Owner Change-88.65%
Ins Owners1.11%
Ins Owner Change0.84%
Market Cap37.84M
Analysts83.08
Price Target33.73 (670.09%)
Short Float %25.67%
Short Ratio23.18
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)2
Avg EPS beat(2)22.52%
Min EPS beat(2)10%
Max EPS beat(2)35.04%
EPS beat(4)4
Avg EPS beat(4)49.33%
Min EPS beat(4)3.03%
Max EPS beat(4)149.25%
EPS beat(8)6
Avg EPS beat(8)25.16%
EPS beat(12)9
Avg EPS beat(12)19%
EPS beat(16)12
Avg EPS beat(16)27.48%
Revenue beat(2)0
Avg Revenue beat(2)-15.31%
Min Revenue beat(2)-16.5%
Max Revenue beat(2)-14.12%
Revenue beat(4)2
Avg Revenue beat(4)-3.51%
Min Revenue beat(4)-16.5%
Max Revenue beat(4)15.94%
Revenue beat(8)3
Avg Revenue beat(8)-3.68%
Revenue beat(12)6
Avg Revenue beat(12)-1.68%
Revenue beat(16)9
Avg Revenue beat(16)15.96%
PT rev (1m)-23.42%
PT rev (3m)-35.22%
EPS NQ rev (1m)0%
EPS NQ rev (3m)1.13%
EPS NY rev (1m)0%
EPS NY rev (3m)-1895.86%
Revenue NQ rev (1m)0%
Revenue NQ rev (3m)-1.11%
Revenue NY rev (1m)0%
Revenue NY rev (3m)-1.95%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S 0.27
P/FCF N/A
P/OCF N/A
P/B N/A
P/tB N/A
EV/EBITDA N/A
EPS(TTM)-8.02
EYN/A
EPS(NY)-10
Fwd EYN/A
FCF(TTM)-14.2
FCFYN/A
OCF(TTM)-14.21
OCFYN/A
SpS16.45
BVpS-23.83
TBVpS-23.83
PEG (NY)N/A
PEG (5Y)N/A
Profitability
Industry RankSector Rank
ROA -48.96%
ROE N/A
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM 96.2%
FCFM N/A
ROA(3y)-50.71%
ROA(5y)-51.1%
ROE(3y)N/A
ROE(5y)N/A
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexcg growth 3YN/A
ROICexcg growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.86%
GM growth 5Y0.37%
F-Score3
Asset Turnover1.11
Health
Industry RankSector Rank
Debt/Equity N/A
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 15.92%
Cap/Sales 0.04%
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 1.33
Quick Ratio 1.28
Altman-Z -19.01
F-Score3
WACC6.12%
ROIC/WACCN/A
Cap/Depr(3y)20.37%
Cap/Depr(5y)20.63%
Cap/Sales(3y)0.06%
Cap/Sales(5y)0.08%
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)57.9%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%42.29%
EPS Next Y-45.56%
EPS Next 2Y0.24%
EPS Next 3Y9.8%
EPS Next 5Y15.54%
Revenue 1Y (TTM)1.18%
Revenue growth 3Y-11.54%
Revenue growth 5Y28.85%
Sales Q2Q%-9.39%
Revenue Next Year-2.58%
Revenue Next 2Y5.3%
Revenue Next 3Y14.14%
Revenue Next 5Y23.31%
EBIT growth 1Y10.21%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year-12.18%
EBIT Next 3YN/A
EBIT Next 5YN/A
FCF growth 1Y-12.25%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-12.34%
OCF growth 3YN/A
OCF growth 5YN/A