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DENALI THERAPEUTICS INC (DNLI) Stock Fundamental Analysis

USA - Nasdaq - NASDAQ:DNLI - US24823R1059 - Common Stock

18 USD
+0.84 (+4.9%)
Last: 11/21/2025, 8:23:39 PM
17.92 USD
-0.08 (-0.44%)
After Hours: 11/21/2025, 8:23:39 PM
Fundamental Rating

2

Taking everything into account, DNLI scores 2 out of 10 in our fundamental rating. DNLI was compared to 535 industry peers in the Biotechnology industry. While DNLI seems to be doing ok healthwise, there are quite some concerns on its profitability. DNLI is valued expensive and it does not seem to be growing.


Dividend Valuation Growth Profitability Health

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1

1. Profitability

1.1 Basic Checks

DNLI had negative earnings in the past year.
In the past year DNLI has reported a negative cash flow from operations.
In the past 5 years DNLI reported 4 times negative net income.
In the past 5 years DNLI reported 4 times negative operating cash flow.
DNLI Yearly Net Income VS EBIT VS OCF VS FCFDNLI Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 200M -200M 400M -400M

1.2 Ratios

DNLI has a Return On Assets (-41.08%) which is comparable to the rest of the industry.
With a decent Return On Equity value of -46.64%, DNLI is doing good in the industry, outperforming 67.73% of the companies in the same industry.
Industry RankSector Rank
ROA -41.08%
ROE -46.64%
ROIC N/A
ROA(3y)-21.89%
ROA(5y)-16.39%
ROE(3y)-26.58%
ROE(5y)-20.75%
ROIC(3y)N/A
ROIC(5y)N/A
DNLI Yearly ROA, ROE, ROICDNLI Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 -10 -20 -30 -40 -50

1.3 Margins

DNLI does not have Profit Margin and Operating Margin and Gross Margin available, so we won't be analyzing them here.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM N/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
DNLI Yearly Profit, Operating, Gross MarginsDNLI Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 -200 -400 -600

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5

2. Health

2.1 Basic Checks

DNLI does not have a ROIC to compare to the WACC, probably because it is not profitable.
DNLI has more shares outstanding than it did 1 year ago.
The number of shares outstanding for DNLI has been increased compared to 5 years ago.
Compared to 1 year ago, DNLI has a worse debt to assets ratio.
DNLI Yearly Shares OutstandingDNLI Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 50M 100M
DNLI Yearly Total Debt VS Total AssetsDNLI Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B 1.5B

2.2 Solvency

DNLI has an Altman-Z score of 8.03. This indicates that DNLI is financially healthy and has little risk of bankruptcy at the moment.
The Altman-Z score of DNLI (8.03) is better than 80.86% of its industry peers.
DNLI has a Debt/Equity ratio of 0.01. This is a healthy value indicating a solid balance between debt and equity.
DNLI has a Debt to Equity ratio of 0.01. This is comparable to the rest of the industry: DNLI outperforms 46.15% of its industry peers.
Industry RankSector Rank
Debt/Equity 0.01
Debt/FCF N/A
Altman-Z 8.03
ROIC/WACCN/A
WACC8.7%
DNLI Yearly LT Debt VS Equity VS FCFDNLI Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M 1B

2.3 Liquidity

DNLI has a Current Ratio of 10.27. This indicates that DNLI is financially healthy and has no problem in meeting its short term obligations.
DNLI has a Current ratio of 10.27. This is amongst the best in the industry. DNLI outperforms 81.80% of its industry peers.
DNLI has a Quick Ratio of 10.27. This indicates that DNLI is financially healthy and has no problem in meeting its short term obligations.
With an excellent Quick ratio value of 10.27, DNLI belongs to the best of the industry, outperforming 81.80% of the companies in the same industry.
Industry RankSector Rank
Current Ratio 10.27
Quick Ratio 10.27
DNLI Yearly Current Assets VS Current LiabilitesDNLI Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B

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3

3. Growth

3.1 Past

DNLI shows a slight negative growth in Earnings Per Share. In the last year, the EPS has decreased by -1.75%.
Looking at the last year, DNLI shows a very negative growth in Revenue. The Revenue has decreased by -100.00% in the last year.
EPS 1Y (TTM)-1.75%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%-17.46%
Revenue 1Y (TTM)-100%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A

3.2 Future

DNLI is expected to show quite a strong growth in Earnings Per Share. In the coming years, the EPS will grow by 13.27% yearly.
Based on estimates for the next years, DNLI will show a very strong growth in Revenue. The Revenue will grow by 138.30% on average per year.
EPS Next Y-14.65%
EPS Next 2Y-4.83%
EPS Next 3Y2.3%
EPS Next 5Y13.27%
Revenue Next Year-99.18%
Revenue Next 2Y178.3%
Revenue Next 3Y182.6%
Revenue Next 5Y138.3%

3.3 Evolution

DNLI Yearly Revenue VS EstimatesDNLI Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 500M 1B 1.5B
DNLI Yearly EPS VS EstimatesDNLI Yearly EPS VS EstimatesYearly EPS VS Estimates 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 0 1 -1 2 -2 -3

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0

4. Valuation

4.1 Price/Earnings Ratio

The Price/Earnings Ratio is negative for DNLI. In the last year negative earnings were reported.
Besides the negative Price/Earnings Ratio, also the Forward Price/Earnings Ratio is negative for DNLI. No positive earnings are expected for the next year.
Industry RankSector Rank
PE N/A
Fwd PE N/A
DNLI Price Earnings VS Forward Price EarningsDNLI Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60 80 100

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
DNLI Per share dataDNLI EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 2 -2 4 6

4.3 Compensation for Growth

PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y-4.83%
EPS Next 3Y2.3%

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0

5. Dividend

5.1 Amount

DNLI does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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DENALI THERAPEUTICS INC

NASDAQ:DNLI (11/21/2025, 8:23:39 PM)

After market: 17.92 -0.08 (-0.44%)

18

+0.84 (+4.9%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)11-06 2025-11-06/amc
Earnings (Next)02-25 2026-02-25/amc
Inst Owners96.07%
Inst Owner Change6.85%
Ins Owners4.85%
Ins Owner Change3.13%
Market Cap2.63B
Revenue(TTM)N/A
Net Income(TTM)-479.00M
Analysts88
Price Target32.23 (79.06%)
Short Float %9.94%
Short Ratio7.35
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)1
Avg EPS beat(2)-4.78%
Min EPS beat(2)-11.43%
Max EPS beat(2)1.88%
EPS beat(4)2
Avg EPS beat(4)2.05%
Min EPS beat(4)-11.43%
Max EPS beat(4)18.24%
EPS beat(8)4
Avg EPS beat(8)2.77%
EPS beat(12)6
Avg EPS beat(12)25.16%
EPS beat(16)7
Avg EPS beat(16)14.02%
Revenue beat(2)0
Avg Revenue beat(2)-100%
Min Revenue beat(2)-100%
Max Revenue beat(2)-100%
Revenue beat(4)0
Avg Revenue beat(4)-100%
Min Revenue beat(4)-100%
Max Revenue beat(4)-100%
Revenue beat(8)0
Avg Revenue beat(8)-98.61%
Revenue beat(12)2
Avg Revenue beat(12)97.93%
Revenue beat(16)4
Avg Revenue beat(16)68.59%
PT rev (1m)0%
PT rev (3m)-2.39%
EPS NQ rev (1m)0.17%
EPS NQ rev (3m)-0.06%
EPS NY rev (1m)1.03%
EPS NY rev (3m)0.68%
Revenue NQ rev (1m)N/A
Revenue NQ rev (3m)-100%
Revenue NY rev (1m)0%
Revenue NY rev (3m)-99.68%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S N/A
P/FCF N/A
P/OCF N/A
P/B 2.56
P/tB 2.56
EV/EBITDA N/A
EPS(TTM)-2.91
EYN/A
EPS(NY)-2.93
Fwd EYN/A
FCF(TTM)-2.52
FCFYN/A
OCF(TTM)-2.39
OCFYN/A
SpS0
BVpS7.02
TBVpS7.02
PEG (NY)N/A
PEG (5Y)N/A
Graham NumberN/A
Profitability
Industry RankSector Rank
ROA -41.08%
ROE -46.64%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM N/A
FCFM N/A
ROA(3y)-21.89%
ROA(5y)-16.39%
ROE(3y)-26.58%
ROE(5y)-20.75%
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexgc growth 3YN/A
ROICexgc growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
F-Score1
Asset Turnover0
Health
Industry RankSector Rank
Debt/Equity 0.01
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 152.74%
Cap/Sales N/A
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 10.27
Quick Ratio 10.27
Altman-Z 8.03
F-Score1
WACC8.7%
ROIC/WACCN/A
Cap/Depr(3y)141.87%
Cap/Depr(5y)112.18%
Cap/Sales(3y)N/A
Cap/Sales(5y)N/A
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)-1.75%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%-17.46%
EPS Next Y-14.65%
EPS Next 2Y-4.83%
EPS Next 3Y2.3%
EPS Next 5Y13.27%
Revenue 1Y (TTM)-100%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A
Revenue Next Year-99.18%
Revenue Next 2Y178.3%
Revenue Next 3Y182.6%
Revenue Next 5Y138.3%
EBIT growth 1Y-7.74%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year-6.25%
EBIT Next 3Y5.09%
EBIT Next 5Y18.15%
FCF growth 1Y-14.7%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-16.01%
OCF growth 3YN/A
OCF growth 5YN/A

DENALI THERAPEUTICS INC / DNLI FAQ

What is the ChartMill fundamental rating of DENALI THERAPEUTICS INC (DNLI) stock?

ChartMill assigns a fundamental rating of 2 / 10 to DNLI.


What is the valuation status for DNLI stock?

ChartMill assigns a valuation rating of 0 / 10 to DENALI THERAPEUTICS INC (DNLI). This can be considered as Overvalued.


How profitable is DENALI THERAPEUTICS INC (DNLI) stock?

DENALI THERAPEUTICS INC (DNLI) has a profitability rating of 1 / 10.


Can you provide the financial health for DNLI stock?

The financial health rating of DENALI THERAPEUTICS INC (DNLI) is 5 / 10.


What is the expected EPS growth for DENALI THERAPEUTICS INC (DNLI) stock?

The Earnings per Share (EPS) of DENALI THERAPEUTICS INC (DNLI) is expected to decline by -14.65% in the next year.