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DENALI THERAPEUTICS INC (DNLI) Stock Fundamental Analysis

USA - NASDAQ:DNLI - US24823R1059 - Common Stock

15.37 USD
-0.8 (-4.95%)
Last: 10/10/2025, 9:21:51 PM
15.17 USD
-0.2 (-1.3%)
After Hours: 10/10/2025, 9:21:51 PM
Fundamental Rating

2

Taking everything into account, DNLI scores 2 out of 10 in our fundamental rating. DNLI was compared to 536 industry peers in the Biotechnology industry. The financial health of DNLI is average, but there are quite some concerns on its profitability. DNLI is valued expensive and it does not seem to be growing.


Dividend Valuation Growth Profitability Health

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1

1. Profitability

1.1 Basic Checks

DNLI had negative earnings in the past year.
In the past year DNLI has reported a negative cash flow from operations.
DNLI had negative earnings in 4 of the past 5 years.
In the past 5 years DNLI reported 4 times negative operating cash flow.
DNLI Yearly Net Income VS EBIT VS OCF VS FCFDNLI Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 200M -200M 400M -400M

1.2 Ratios

DNLI's Return On Assets of -30.77% is fine compared to the rest of the industry. DNLI outperforms 65.86% of its industry peers.
DNLI's Return On Equity of -34.38% is fine compared to the rest of the industry. DNLI outperforms 75.56% of its industry peers.
Industry RankSector Rank
ROA -30.77%
ROE -34.38%
ROIC N/A
ROA(3y)-21.89%
ROA(5y)-16.39%
ROE(3y)-26.58%
ROE(5y)-20.75%
ROIC(3y)N/A
ROIC(5y)N/A
DNLI Yearly ROA, ROE, ROICDNLI Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 -10 -20 -30 -40 -50

1.3 Margins

The Profit Margin and Operating Margin and Gross Margin are not available for DNLI so they could not be analyzed.
Industry RankSector Rank
OM N/A
PM (TTM) N/A
GM N/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
DNLI Yearly Profit, Operating, Gross MarginsDNLI Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 -200 -400 -600

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5

2. Health

2.1 Basic Checks

DNLI does not have a ROIC to compare to the WACC, probably because it is not profitable.
DNLI has more shares outstanding than it did 1 year ago.
The number of shares outstanding for DNLI has been increased compared to 5 years ago.
DNLI has a worse debt/assets ratio than last year.
DNLI Yearly Shares OutstandingDNLI Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 50M 100M
DNLI Yearly Total Debt VS Total AssetsDNLI Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B 1.5B

2.2 Solvency

DNLI has an Altman-Z score of 7.71. This indicates that DNLI is financially healthy and has little risk of bankruptcy at the moment.
DNLI's Altman-Z score of 7.71 is fine compared to the rest of the industry. DNLI outperforms 79.29% of its industry peers.
A Debt/Equity ratio of 0.00 indicates that DNLI is not too dependend on debt financing.
DNLI has a Debt to Equity ratio (0.00) which is comparable to the rest of the industry.
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Altman-Z 7.71
ROIC/WACCN/A
WACC9.56%
DNLI Yearly LT Debt VS Equity VS FCFDNLI Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M 1B

2.3 Liquidity

DNLI has a Current Ratio of 8.46. This indicates that DNLI is financially healthy and has no problem in meeting its short term obligations.
DNLI has a better Current ratio (8.46) than 75.37% of its industry peers.
A Quick Ratio of 8.46 indicates that DNLI has no problem at all paying its short term obligations.
Looking at the Quick ratio, with a value of 8.46, DNLI is in the better half of the industry, outperforming 75.37% of the companies in the same industry.
Industry RankSector Rank
Current Ratio 8.46
Quick Ratio 8.46
DNLI Yearly Current Assets VS Current LiabilitesDNLI Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B

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3

3. Growth

3.1 Past

DNLI shows a small growth in Earnings Per Share. In the last year, the EPS has grown by 5.08%.
Looking at the last year, DNLI shows a very negative growth in Revenue. The Revenue has decreased by -100.00% in the last year.
EPS 1Y (TTM)5.08%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%-22.03%
Revenue 1Y (TTM)-100%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A

3.2 Future

DNLI is expected to show quite a strong growth in Earnings Per Share. In the coming years, the EPS will grow by 13.27% yearly.
Based on estimates for the next years, DNLI will show a very strong growth in Revenue. The Revenue will grow by 138.30% on average per year.
EPS Next Y-15.85%
EPS Next 2Y-6.39%
EPS Next 3Y1.44%
EPS Next 5Y13.27%
Revenue Next Year-99.18%
Revenue Next 2Y180.11%
Revenue Next 3Y183.22%
Revenue Next 5Y138.3%

3.3 Evolution

DNLI Yearly Revenue VS EstimatesDNLI Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 500M 1B 1.5B
DNLI Yearly EPS VS EstimatesDNLI Yearly EPS VS EstimatesYearly EPS VS Estimates 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 0 1 -1 2 -2 -3

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0

4. Valuation

4.1 Price/Earnings Ratio

DNLI reported negative earnings for the last year, which makes the Price/Earnings Ratio negative.
Besides the negative Price/Earnings Ratio, also the Forward Price/Earnings Ratio is negative for DNLI. No positive earnings are expected for the next year.
Industry RankSector Rank
PE N/A
Fwd PE N/A
DNLI Price Earnings VS Forward Price EarningsDNLI Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
DNLI Per share dataDNLI EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 2 -2 4 6 8

4.3 Compensation for Growth

PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y-6.39%
EPS Next 3Y1.44%

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0

5. Dividend

5.1 Amount

DNLI does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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DENALI THERAPEUTICS INC

NASDAQ:DNLI (10/10/2025, 9:21:51 PM)

After market: 15.17 -0.2 (-1.3%)

15.37

-0.8 (-4.95%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)08-11 2025-08-11/amc
Earnings (Next)11-04 2025-11-04
Inst Owners96.07%
Inst Owner Change0%
Ins Owners4.85%
Ins Owner Change0.58%
Market Cap2.25B
Analysts88
Price Target32.79 (113.34%)
Short Float %9.92%
Short Ratio6.58
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)1
Avg EPS beat(2)8.87%
Min EPS beat(2)-0.5%
Max EPS beat(2)18.24%
EPS beat(4)2
Avg EPS beat(4)6.14%
Min EPS beat(4)-8.8%
Max EPS beat(4)18.24%
EPS beat(8)4
Avg EPS beat(8)38.34%
EPS beat(12)6
Avg EPS beat(12)26.96%
EPS beat(16)6
Avg EPS beat(16)9.31%
Revenue beat(2)0
Avg Revenue beat(2)-100%
Min Revenue beat(2)-100%
Max Revenue beat(2)-100%
Revenue beat(4)0
Avg Revenue beat(4)-100%
Min Revenue beat(4)-100%
Max Revenue beat(4)-100%
Revenue beat(8)2
Avg Revenue beat(8)184.22%
Revenue beat(12)4
Avg Revenue beat(12)121.08%
Revenue beat(16)4
Avg Revenue beat(16)75.15%
PT rev (1m)0%
PT rev (3m)-2.39%
EPS NQ rev (1m)0%
EPS NQ rev (3m)0%
EPS NY rev (1m)-0.08%
EPS NY rev (3m)-0.38%
Revenue NQ rev (1m)0%
Revenue NQ rev (3m)0%
Revenue NY rev (1m)-99.26%
Revenue NY rev (3m)-99.69%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S N/A
P/FCF N/A
P/OCF N/A
P/B 1.83
P/tB 1.83
EV/EBITDA N/A
EPS(TTM)-2.8
EYN/A
EPS(NY)-3.02
Fwd EYN/A
FCF(TTM)-2.49
FCFYN/A
OCF(TTM)-2.38
OCFYN/A
SpS0
BVpS8.41
TBVpS8.41
PEG (NY)N/A
PEG (5Y)N/A
Profitability
Industry RankSector Rank
ROA -30.77%
ROE -34.38%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) N/A
GM N/A
FCFM N/A
ROA(3y)-21.89%
ROA(5y)-16.39%
ROE(3y)-26.58%
ROE(5y)-20.75%
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexcg growth 3YN/A
ROICexcg growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
F-Score1
Asset Turnover0
Health
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 176.96%
Cap/Sales N/A
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 8.46
Quick Ratio 8.46
Altman-Z 7.71
F-Score1
WACC9.56%
ROIC/WACCN/A
Cap/Depr(3y)141.82%
Cap/Depr(5y)112.16%
Cap/Sales(3y)N/A
Cap/Sales(5y)N/A
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)5.08%
EPS 3YN/A
EPS 5YN/A
EPS Q2Q%-22.03%
EPS Next Y-15.85%
EPS Next 2Y-6.39%
EPS Next 3Y1.44%
EPS Next 5Y13.27%
Revenue 1Y (TTM)-100%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%N/A
Revenue Next Year-99.18%
Revenue Next 2Y180.11%
Revenue Next 3Y183.22%
Revenue Next 5Y138.3%
EBIT growth 1Y-155.18%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year-6.25%
EBIT Next 3Y5.09%
EBIT Next 5Y18.15%
FCF growth 1Y1.97%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y2.88%
OCF growth 3YN/A
OCF growth 5YN/A