DENALI THERAPEUTICS INC (DNLI) Stock Price, Forecast & Analysis

NASDAQ:DNLI • US24823R1059

22.29 USD
+0.86 (+4.01%)
At close: Feb 25, 2026
22.6912 USD
+0.4 (+1.8%)
After Hours: 2/25/2026, 8:05:29 PM

DNLI Key Statistics, Chart & Performance

Key Statistics
Market Cap3.47B
Revenue(TTM)N/A
Net Income(TTM)-479.03M
Shares155.77M
Float140.31M
52 Week High23.77
52 Week Low10.57
Yearly DividendN/A
Dividend Yield0%
EPS(TTM)-2.91
PEN/A
Fwd PEN/A
Earnings (Next)05-04
IPO2017-12-08
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology
DNLI short term performance overview.The bars show the price performance of DNLI in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 10 20 30 40

DNLI long term performance overview.The bars show the price performance of DNLI in the last 1, 2 and 3 years. 1 year 2 years 3 years 0 10 -10 20 30

The current stock price of DNLI is 22.29 USD. In the past month the price increased by 4.89%. In the past year, price increased by 34.6%.

DENALI THERAPEUTICS INC / DNLI Daily stock chart

DNLI Technical Analysis

ChartMill assigns a technical rating of 10 / 10 to DNLI. When comparing the yearly performance of all stocks, DNLI is one of the better performing stocks in the market, outperforming 80.98% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating
DNLI Full Technical Analysis Report

DNLI Fundamental Analysis

ChartMill assigns a fundamental rating of 2 / 10 to DNLI. While DNLI seems to be doing ok healthwise, there are quite some concerns on its profitability.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend
DNLI Full Fundamental Analysis Report

DNLI Financial Highlights

Over the last trailing twelve months DNLI reported a non-GAAP Earnings per Share(EPS) of -2.91. The EPS decreased by -1.75% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -41.08%
ROE -46.64%
Debt/Equity 0.01
Chartmill High Growth Momentum
EPS Q2Q%-17.46%
Sales Q2Q%N/A
EPS 1Y (TTM)-1.75%
Revenue 1Y (TTM)-100%
DNLI financials

DNLI Forecast & Estimates

24 analysts have analysed DNLI and the average price target is 32.95 USD. This implies a price increase of 47.84% is expected in the next year compared to the current price of 22.29.

For the next year, analysts expect an EPS growth of -14.15% and a revenue growth -87.68% for DNLI


Analysts
Analysts88.33
Price Target32.95 (47.82%)
EPS Next Y-14.15%
Revenue Next Year-87.68%
DNLI Analyst EstimatesDNLI Analyst Ratings

DNLI Ownership

Ownership
Inst Owners91.98%
Ins Owners4.28%
Short Float %9.66%
Short Ratio7.95
DNLI Ownership

DNLI Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
SymbolCompany NameTechnical RatingFundamental RatingFPEMarket Cap
ABBV ABBVIE INC15.63401.054B
AMGN AMGEN INC17.06206.954B
GILD GILEAD SCIENCES INC16.49182.529B
VRTX VERTEX PHARMACEUTICALS INC23.69122.559B
REGN REGENERON PHARMACEUTICALS16.8882.914B
ALNY ALNYLAM PHARMACEUTICALS INC48.8743.248B
INSM INSMED INC N/A31.694B
NTRA NATERA INC N/A29.474B
BIIB BIOGEN INC12.5427.992B
UTHR UNITED THERAPEUTICS CORP18.1623.041B

About DNLI

Company Profile

DNLI logo image Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. The company is headquartered in South San Francisco, California and currently employs 517 full-time employees. The company went IPO on 2017-12-08. The firm is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. The company has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). The company is also exploring programs in oncology, inflammation, and other diseases.

Company Info

DENALI THERAPEUTICS INC

161 Oyster Point Blvd.

South San Francisco CALIFORNIA 94080 US

CEO: Ryan J. Watts

Employees: 517

DNLI Company Website

DNLI Investor Relations

Phone: 16508668547

DENALI THERAPEUTICS INC / DNLI FAQ

What does DENALI THERAPEUTICS INC do?

Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. The company is headquartered in South San Francisco, California and currently employs 517 full-time employees. The company went IPO on 2017-12-08. The firm is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. The company has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). The company is also exploring programs in oncology, inflammation, and other diseases.


Can you provide the latest stock price for DENALI THERAPEUTICS INC?

The current stock price of DNLI is 22.29 USD. The price increased by 4.01% in the last trading session.


Does DENALI THERAPEUTICS INC pay dividends?

DNLI does not pay a dividend.


How is the ChartMill rating for DENALI THERAPEUTICS INC?

DNLI has a ChartMill Technical rating of 10 out of 10 and a ChartMill Fundamental rating of 2 out of 10.


Is DENALI THERAPEUTICS INC (DNLI) expected to grow?

The Revenue of DENALI THERAPEUTICS INC (DNLI) is expected to decline by -87.68% in the next year. Check the estimates tab for more information on the EPS, Sales, EBIT and EBITDA future analyst estimates.


What is the ownership structure of DENALI THERAPEUTICS INC (DNLI)?

You can find the ownership structure of DENALI THERAPEUTICS INC (DNLI) on the Ownership tab.


What is the Short Interest ratio of DENALI THERAPEUTICS INC (DNLI) stock?

The outstanding short interest for DENALI THERAPEUTICS INC (DNLI) is 9.66% of its float.