Logo image of DNLI

DENALI THERAPEUTICS INC (DNLI) Stock Price, Forecast & Analysis

USA - Nasdaq - NASDAQ:DNLI - US24823R1059 - Common Stock

16.99 USD
+0.18 (+1.07%)
Last: 12/24/2025, 8:25:24 PM
16.99 USD
0 (0%)
After Hours: 12/24/2025, 8:25:24 PM

DNLI Key Statistics, Chart & Performance

Key Statistics
Market Cap2.49B
Revenue(TTM)N/A
Net Income(TTM)-478.94M
Shares146.66M
Float131.28M
52 Week High24.35
52 Week Low10.57
Yearly DividendN/A
Dividend Yield0%
EPS(TTM)-2.91
PEN/A
Fwd PEN/A
Earnings (Next)02-25 2026-02-25/amc
IPO2017-12-08
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


DNLI short term performance overview.The bars show the price performance of DNLI in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 0 10 -10 20

DNLI long term performance overview.The bars show the price performance of DNLI in the last 1, 2 and 3 years. 1 year 2 years 3 years -10 -20 -30

The current stock price of DNLI is 16.99 USD. In the past month the price decreased by -11.19%. In the past year, price decreased by -17.56%.

DENALI THERAPEUTICS INC / DNLI Daily stock chart

DNLI Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
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TA
FA
PE
Market Cap
ABBV ABBVIE INC 24.33 406.30B
AMGN AMGEN INC 15.27 179.83B
GILD GILEAD SCIENCES INC 15.34 155.92B
VRTX VERTEX PHARMACEUTICALS INC 26.67 117.47B
REGN REGENERON PHARMACEUTICALS 17.41 82.37B
ALNY ALNYLAM PHARMACEUTICALS INC 785.67 52.94B
INSM INSMED INC N/A 37.84B
NTRA NATERA INC N/A 32.51B
BIIB BIOGEN INC 10.53 25.87B
UTHR UNITED THERAPEUTICS CORP 19.5 22.16B
INCY INCYTE CORP 15.64 19.72B
EXAS EXACT SCIENCES CORP N/A 19.27B

About DNLI

Company Profile

DNLI logo image Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. The company is headquartered in South San Francisco, California and currently employs 517 full-time employees. The company went IPO on 2017-12-08. The firm is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. The company has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). The company is also exploring programs in oncology, inflammation, and other diseases.

Company Info

DENALI THERAPEUTICS INC

161 Oyster Point Blvd.

South San Francisco CALIFORNIA 94080 US

CEO: Ryan J. Watts

Employees: 422

DNLI Company Website

DNLI Investor Relations

Phone: 16508668547

DENALI THERAPEUTICS INC / DNLI FAQ

What does DENALI THERAPEUTICS INC do?

Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. The company is headquartered in South San Francisco, California and currently employs 517 full-time employees. The company went IPO on 2017-12-08. The firm is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. The company has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). The company is also exploring programs in oncology, inflammation, and other diseases.


What is the current price of DNLI stock?

The current stock price of DNLI is 16.99 USD. The price increased by 1.07% in the last trading session.


Does DENALI THERAPEUTICS INC pay dividends?

DNLI does not pay a dividend.


What is the ChartMill technical and fundamental rating of DNLI stock?

DNLI has a ChartMill Technical rating of 4 out of 10 and a ChartMill Fundamental rating of 2 out of 10.


Can you provide the PE ratio for DNLI stock?

DENALI THERAPEUTICS INC (DNLI) does not have a PE ratio as the earnings reported over the last twelve months were negative (-2.91).


Is DENALI THERAPEUTICS INC (DNLI) stock a good buy?

This depends on your investment goals. Check the Technical and Fundamental Analysis tabs for insights on DNLI.


What is the employee count for DNLI stock?

DENALI THERAPEUTICS INC (DNLI) currently has 422 employees.


DNLI Technical Analysis

ChartMill assigns a technical rating of 4 / 10 to DNLI. When comparing the yearly performance of all stocks, DNLI turns out to be only a medium performer in the overall market: it outperformed 49.67% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating

DNLI Fundamental Analysis

ChartMill assigns a fundamental rating of 2 / 10 to DNLI. DNLI scores quite bad on profitability, while its financial health is fine. Not spectacular, but in line with the averages.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

DNLI Financial Highlights

Over the last trailing twelve months DNLI reported a non-GAAP Earnings per Share(EPS) of -2.91. The EPS decreased by -1.75% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -41.07%
ROE -46.63%
Debt/Equity 0.01
Chartmill High Growth Momentum
EPS Q2Q%-17.46%
Sales Q2Q%N/A
EPS 1Y (TTM)-1.75%
Revenue 1Y (TTM)-100%

DNLI Forecast & Estimates

24 analysts have analysed DNLI and the average price target is 32.86 USD. This implies a price increase of 93.4% is expected in the next year compared to the current price of 16.99.

For the next year, analysts expect an EPS growth of -13.54% and a revenue growth -87.68% for DNLI


Analysts
Analysts88.33
Price Target32.86 (93.41%)
EPS Next Y-13.54%
Revenue Next Year-87.68%

DNLI Ownership

Ownership
Inst Owners97.59%
Ins Owners4.55%
Short Float %9.89%
Short Ratio7.82