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AGIOS PHARMACEUTICALS INC (AGIO) Stock Fundamental Analysis

USA - NASDAQ:AGIO - US00847X1046 - Common Stock

43.45 USD
+0.8 (+1.88%)
Last: 10/21/2025, 8:00:00 PM
43.45 USD
0 (0%)
After Hours: 10/21/2025, 8:00:00 PM
Fundamental Rating

5

We assign a fundamental rating of 5 out of 10 to AGIO. AGIO was compared to 534 industry peers in the Biotechnology industry. While AGIO has a great health rating, there are worries on its profitability. AGIO is quite expensive at the moment. It does show a decent growth rate.


Dividend Valuation Growth Profitability Health

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3

1. Profitability

1.1 Basic Checks

AGIO had negative earnings in the past year.
In the past year AGIO has reported a negative cash flow from operations.
In multiple years AGIO reported negative net income over the last 5 years.
In the past 5 years AGIO always reported negative operating cash flow.
AGIO Yearly Net Income VS EBIT VS OCF VS FCFAGIO Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M 1B 1.5B

1.2 Ratios

AGIO's Return On Assets of 44.19% is amongst the best of the industry. AGIO outperforms 99.44% of its industry peers.
AGIO has a Return On Equity of 47.47%. This is amongst the best in the industry. AGIO outperforms 98.50% of its industry peers.
Industry RankSector Rank
ROA 44.19%
ROE 47.47%
ROIC N/A
ROA(3y)-5.26%
ROA(5y)11.49%
ROE(3y)-6.92%
ROE(5y)4.3%
ROIC(3y)N/A
ROIC(5y)N/A
AGIO Yearly ROA, ROE, ROICAGIO Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 50 -50 100

1.3 Margins

AGIO's Profit Margin of 1590.42% is amongst the best of the industry. AGIO outperforms 99.63% of its industry peers.
AGIO's Gross Margin of 88.18% is amongst the best of the industry. AGIO outperforms 89.70% of its industry peers.
Industry RankSector Rank
OM N/A
PM (TTM) 1590.42%
GM 88.18%
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
AGIO Yearly Profit, Operating, Gross MarginsAGIO Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 1K -1K -2K

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9

2. Health

2.1 Basic Checks

AGIO does not have a ROIC to compare to the WACC, probably because it is not profitable.
AGIO has more shares outstanding than it did 1 year ago.
Compared to 5 years ago, AGIO has less shares outstanding
AGIO has no outstanding debt. Therefor its Debt/Equity and Debt/FCF ratios are 0 and belong to the best of the industry.
AGIO Yearly Shares OutstandingAGIO Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 20M 40M 60M
AGIO Yearly Total Debt VS Total AssetsAGIO Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 500M 1B 1.5B

2.2 Solvency

AGIO has an Altman-Z score of 14.06. This indicates that AGIO is financially healthy and has little risk of bankruptcy at the moment.
AGIO's Altman-Z score of 14.06 is amongst the best of the industry. AGIO outperforms 86.52% of its industry peers.
There is no outstanding debt for AGIO. This means it has a Debt/Equity and Debt/FCF ratio of 0 and it is amongst the best of the sector and industry.
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Altman-Z 14.06
ROIC/WACCN/A
WACC9.35%
AGIO Yearly LT Debt VS Equity VS FCFAGIO Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 500M 1B 1.5B

2.3 Liquidity

AGIO has a Current Ratio of 14.48. This indicates that AGIO is financially healthy and has no problem in meeting its short term obligations.
With an excellent Current ratio value of 14.48, AGIO belongs to the best of the industry, outperforming 89.33% of the companies in the same industry.
A Quick Ratio of 14.04 indicates that AGIO has no problem at all paying its short term obligations.
The Quick ratio of AGIO (14.04) is better than 88.58% of its industry peers.
Industry RankSector Rank
Current Ratio 14.48
Quick Ratio 14.04
AGIO Yearly Current Assets VS Current LiabilitesAGIO Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 200M 400M 600M 800M 1B

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5

3. Growth

3.1 Past

The earnings per share for AGIO have decreased strongly by -12.86% in the last year.
Measured over the past years, AGIO shows a very negative growth in Earnings Per Share. The EPS has been decreasing by -24.03% on average per year.
Looking at the last year, AGIO shows a very strong growth in Revenue. The Revenue has grown by 30.56%.
EPS 1Y (TTM)-12.86%
EPS 3Y-24.03%
EPS 5YN/A
EPS Q2Q%-14.2%
Revenue 1Y (TTM)30.56%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%44.57%

3.2 Future

The Earnings Per Share is expected to grow by 16.93% on average over the next years. This is quite good.
AGIO is expected to show a strong growth in Revenue. In the coming years, the Revenue will grow by 92.49% yearly.
EPS Next Y-8.09%
EPS Next 2Y-3.61%
EPS Next 3Y7.31%
EPS Next 5Y16.93%
Revenue Next Year26.07%
Revenue Next 2Y76.9%
Revenue Next 3Y94.64%
Revenue Next 5Y92.49%

3.3 Evolution

When comparing the EPS growth rate of the last years to the growth rate of the upcoming years, we see that the growth is accelerating.
AGIO Yearly Revenue VS EstimatesAGIO Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 500M 1B 1.5B
AGIO Yearly EPS VS EstimatesAGIO Yearly EPS VS EstimatesYearly EPS VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 0 10 20

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0

4. Valuation

4.1 Price/Earnings Ratio

AGIO reported negative earnings for the last year, which makes the Price/Earnings Ratio negative.
Also next year AGIO is expected to report negative earnings again, which makes the also the Forward Price/Earnings Ratio negative.
Industry RankSector Rank
PE N/A
Fwd PE N/A
AGIO Price Earnings VS Forward Price EarningsAGIO Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 0 20 40 60

4.2 Price Multiples

Industry RankSector Rank
P/FCF N/A
EV/EBITDA N/A
AGIO Per share dataAGIO EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 0 10 20

4.3 Compensation for Growth

PEG (NY)N/A
PEG (5Y)N/A
EPS Next 2Y-3.61%
EPS Next 3Y7.31%

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0

5. Dividend

5.1 Amount

AGIO does not give a dividend.
Industry RankSector Rank
Dividend Yield N/A

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AGIOS PHARMACEUTICALS INC

NASDAQ:AGIO (10/21/2025, 8:00:00 PM)

After market: 43.45 0 (0%)

43.45

+0.8 (+1.88%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)07-31 2025-07-31/bmo
Earnings (Next)10-30 2025-10-30/bmo
Inst Owners108.68%
Inst Owner Change0.1%
Ins Owners0.87%
Ins Owner Change0.86%
Market Cap2.52B
Analysts78.57
Price Target49.57 (14.09%)
Short Float %8.59%
Short Ratio5.63
Dividend
Industry RankSector Rank
Dividend Yield N/A
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)1
Avg EPS beat(2)5.06%
Min EPS beat(2)-4.68%
Max EPS beat(2)14.81%
EPS beat(4)2
Avg EPS beat(4)-71.89%
Min EPS beat(4)-314.16%
Max EPS beat(4)16.46%
EPS beat(8)4
Avg EPS beat(8)-34.24%
EPS beat(12)8
Avg EPS beat(12)-7.97%
EPS beat(16)11
Avg EPS beat(16)-5.1%
Revenue beat(2)1
Avg Revenue beat(2)8.78%
Min Revenue beat(2)-11.26%
Max Revenue beat(2)28.81%
Revenue beat(4)2
Avg Revenue beat(4)5.81%
Min Revenue beat(4)-11.26%
Max Revenue beat(4)28.81%
Revenue beat(8)2
Avg Revenue beat(8)-0.72%
Revenue beat(12)4
Avg Revenue beat(12)-3.31%
Revenue beat(16)5
Avg Revenue beat(16)-11.5%
PT rev (1m)0%
PT rev (3m)-10%
EPS NQ rev (1m)0%
EPS NQ rev (3m)0.85%
EPS NY rev (1m)-0.34%
EPS NY rev (3m)-2.45%
Revenue NQ rev (1m)-0.7%
Revenue NQ rev (3m)4.8%
Revenue NY rev (1m)0.08%
Revenue NY rev (3m)1.19%
Valuation
Industry RankSector Rank
PE N/A
Fwd PE N/A
P/S 61.76
P/FCF N/A
P/OCF N/A
P/B 1.84
P/tB 1.84
EV/EBITDA N/A
EPS(TTM)-7.34
EYN/A
EPS(NY)-7.51
Fwd EYN/A
FCF(TTM)-7.04
FCFYN/A
OCF(TTM)-6.99
OCFYN/A
SpS0.7
BVpS23.57
TBVpS23.57
PEG (NY)N/A
PEG (5Y)N/A
Profitability
Industry RankSector Rank
ROA 44.19%
ROE 47.47%
ROCE N/A
ROIC N/A
ROICexc N/A
ROICexgc N/A
OM N/A
PM (TTM) 1590.42%
GM 88.18%
FCFM N/A
ROA(3y)-5.26%
ROA(5y)11.49%
ROE(3y)-6.92%
ROE(5y)4.3%
ROIC(3y)N/A
ROIC(5y)N/A
ROICexc(3y)N/A
ROICexc(5y)N/A
ROICexgc(3y)N/A
ROICexgc(5y)N/A
ROCE(3y)N/A
ROCE(5y)N/A
ROICexcg growth 3YN/A
ROICexcg growth 5YN/A
ROICexc growth 3YN/A
ROICexc growth 5YN/A
OM growth 3YN/A
OM growth 5YN/A
PM growth 3YN/A
PM growth 5YN/A
GM growth 3YN/A
GM growth 5YN/A
F-Score4
Asset Turnover0.03
Health
Industry RankSector Rank
Debt/Equity 0
Debt/FCF N/A
Debt/EBITDA N/A
Cap/Depr 57.67%
Cap/Sales 7.41%
Interest Coverage N/A
Cash Conversion N/A
Profit Quality N/A
Current Ratio 14.48
Quick Ratio 14.04
Altman-Z 14.06
F-Score4
WACC9.35%
ROIC/WACCN/A
Cap/Depr(3y)33.97%
Cap/Depr(5y)62.68%
Cap/Sales(3y)14.2%
Cap/Sales(5y)N/A
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)-12.86%
EPS 3Y-24.03%
EPS 5YN/A
EPS Q2Q%-14.2%
EPS Next Y-8.09%
EPS Next 2Y-3.61%
EPS Next 3Y7.31%
EPS Next 5Y16.93%
Revenue 1Y (TTM)30.56%
Revenue growth 3YN/A
Revenue growth 5YN/A
Sales Q2Q%44.57%
Revenue Next Year26.07%
Revenue Next 2Y76.9%
Revenue Next 3Y94.64%
Revenue Next 5Y92.49%
EBIT growth 1Y-13.94%
EBIT growth 3YN/A
EBIT growth 5YN/A
EBIT Next Year-18.55%
EBIT Next 3Y6.42%
EBIT Next 5YN/A
FCF growth 1Y-36.34%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-35.6%
OCF growth 3YN/A
OCF growth 5YN/A