Logo image of SYRE

SPYRE THERAPEUTICS INC (SYRE) Stock Price, Forecast & Analysis

USA - Nasdaq - NASDAQ:SYRE - US00773J2024 - Common Stock

33.05 USD
-0.18 (-0.54%)
Last: 12/24/2025, 8:02:42 PM
33.32 USD
+0.27 (+0.82%)
After Hours: 12/24/2025, 8:02:42 PM

SYRE Key Statistics, Chart & Performance

Key Statistics
Market Cap2.56B
Revenue(TTM)N/A
Net Income(TTM)-208.02M
Shares77.59M
Float71.16M
52 Week High35.31
52 Week Low10.91
Yearly DividendN/A
Dividend Yield0%
EPS(TTM)-2.33
PEN/A
Fwd PEN/A
Earnings (Next)02-25 2026-02-25/amc
IPO2016-04-07
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


SYRE short term performance overview.The bars show the price performance of SYRE in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 0 20 40 60 80 100

SYRE long term performance overview.The bars show the price performance of SYRE in the last 1, 2 and 3 years. 1 year 2 years 3 years 10 20 30 40 50

The current stock price of SYRE is 33.05 USD. In the past month the price increased by 13.18%. In the past year, price increased by 39.63%.

SPYRE THERAPEUTICS INC / SYRE Daily stock chart

SYRE Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
Symbol
Company Name
TA
FA
PE
Market Cap
ABBV ABBVIE INC 24.33 406.30B
AMGN AMGEN INC 15.27 179.83B
GILD GILEAD SCIENCES INC 15.34 155.92B
VRTX VERTEX PHARMACEUTICALS INC 26.67 117.47B
REGN REGENERON PHARMACEUTICALS 17.41 82.37B
ALNY ALNYLAM PHARMACEUTICALS INC 785.67 52.94B
INSM INSMED INC N/A 37.84B
NTRA NATERA INC N/A 32.51B
BIIB BIOGEN INC 10.53 25.87B
UTHR UNITED THERAPEUTICS CORP 19.5 22.16B
INCY INCYTE CORP 15.64 19.72B
EXAS EXACT SCIENCES CORP N/A 19.27B

About SYRE

Company Profile

SYRE logo image Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. The company is headquartered in Waltham, Massachusetts and currently employs 95 full-time employees. The company went IPO on 2016-04-07. Its pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, SPY230, SPY002, SPY001, and SPY120. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a preclinical-stage program designed to bind to Interleukin 23 (IL-23) and incorporates half-life extending modifications.

Company Info

SPYRE THERAPEUTICS INC

221 Crescent Street, Suite 105

Waltham MASSACHUSETTS US

Employees: 65

SYRE Company Website

SYRE Investor Relations

Phone: 16176515940.0

SPYRE THERAPEUTICS INC / SYRE FAQ

What does SPYRE THERAPEUTICS INC do?

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. The company is headquartered in Waltham, Massachusetts and currently employs 95 full-time employees. The company went IPO on 2016-04-07. Its pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, SPY230, SPY002, SPY001, and SPY120. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a preclinical-stage program designed to bind to Interleukin 23 (IL-23) and incorporates half-life extending modifications.


What is the current price of SYRE stock?

The current stock price of SYRE is 33.05 USD. The price decreased by -0.54% in the last trading session.


What is the dividend status of SPYRE THERAPEUTICS INC?

SYRE does not pay a dividend.


How is the ChartMill rating for SPYRE THERAPEUTICS INC?

SYRE has a ChartMill Technical rating of 9 out of 10 and a ChartMill Fundamental rating of 3 out of 10.


What sector and industry does SPYRE THERAPEUTICS INC belong to?

SPYRE THERAPEUTICS INC (SYRE) operates in the Health Care sector and the Biotechnology industry.


What is SPYRE THERAPEUTICS INC worth?

SPYRE THERAPEUTICS INC (SYRE) has a market capitalization of 2.56B USD. This makes SYRE a Mid Cap stock.


SYRE Technical Analysis

ChartMill assigns a technical rating of 9 / 10 to SYRE. When comparing the yearly performance of all stocks, SYRE is one of the better performing stocks in the market, outperforming 95.41% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating

SYRE Fundamental Analysis

ChartMill assigns a fundamental rating of 3 / 10 to SYRE. While SYRE has a great health rating, there are worries on its profitability.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

SYRE Financial Highlights

Over the last trailing twelve months SYRE reported a non-GAAP Earnings per Share(EPS) of -2.33. The EPS increased by 68.81% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -34.19%
ROE -40.17%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%88.97%
Sales Q2Q%N/A
EPS 1Y (TTM)68.81%
Revenue 1Y (TTM)-100%

SYRE Forecast & Estimates

19 analysts have analysed SYRE and the average price target is 53.13 USD. This implies a price increase of 60.76% is expected in the next year compared to the current price of 33.05.

For the next year, analysts expect an EPS growth of 48.4% and a revenue growth -100% for SYRE


Analysts
Analysts89.47
Price Target53.13 (60.76%)
EPS Next Y48.4%
Revenue Next Year-100%

SYRE Ownership

Ownership
Inst Owners82.73%
Ins Owners6.72%
Short Float %15.68%
Short Ratio11.38