Logo image of SYRE

SPYRE THERAPEUTICS INC (SYRE) Stock Overview

USA - NASDAQ:SYRE - US00773J2024 - Common Stock

15.94 USD
-0.52 (-3.16%)
Last: 10/2/2025, 12:08:32 PM

SYRE Key Statistics, Chart & Performance

Key Statistics
52 Week High40.26
52 Week Low10.91
Market Cap962.78M
Shares60.40M
Float53.54M
Yearly DividendN/A
Dividend YieldN/A
EPS(TTM)-3.54
PEN/A
Fwd PEN/A
Earnings (Next)11-05 2025-11-05/amc
IPO04-07 2016-04-07
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


SYRE short term performance overview.The bars show the price performance of SYRE in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 0 10 20

SYRE long term performance overview.The bars show the price performance of SYRE in the last 1, 2 and 3 years. 1 year 2 years 3 years -10 -20 -30 -40

The current stock price of SYRE is 15.94 USD. In the past month the price decreased by -2.08%. In the past year, price decreased by -43.53%.

SPYRE THERAPEUTICS INC / SYRE Daily stock chart

SYRE Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
Symbol
Company Name
TA
FA
PE
Market Cap
ABBV ABBVIE INC 22.47 420.29B
AMGN AMGEN INC 13.59 159.57B
GILD GILEAD SCIENCES INC 14.18 136.20B
VRTX VERTEX PHARMACEUTICALS INC 24.17 104.99B
REGN REGENERON PHARMACEUTICALS 13.16 63.65B
ALNY ALNYLAM PHARMACEUTICALS INC N/A 59.36B
ARGX ARGENX SE - ADR 84.47 47.92B
ONC BEONE MEDICINES LTD-ADR 6.12 41.62B
INSM INSMED INC N/A 31.29B
BNTX BIONTECH SE-ADR N/A 24.83B
BIIB BIOGEN INC 9.63 22.61B
NTRA NATERA INC N/A 21.96B

About SYRE

Company Profile

SYRE logo image Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. The company is headquartered in Waltham, Massachusetts and currently employs 87 full-time employees. The company went IPO on 2016-04-07. Its pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, SPY230, SPY002, SPY001, and SPY120. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a preclinical-stage program designed to bind to Interleukin 23 (IL-23) and incorporates half-life extending modifications.

Company Info

SPYRE THERAPEUTICS INC

221 Crescent Street, Suite 105

Waltham MASSACHUSETTS US

Employees: 65

SYRE Company Website

SYRE Investor Relations

Phone: 16176515940.0

SPYRE THERAPEUTICS INC / SYRE FAQ

What is the stock price of SPYRE THERAPEUTICS INC today?

The current stock price of SYRE is 15.94 USD. The price decreased by -3.16% in the last trading session.


What is the ticker symbol for SPYRE THERAPEUTICS INC stock?

The exchange symbol of SPYRE THERAPEUTICS INC is SYRE and it is listed on the Nasdaq exchange.


On which exchange is SYRE stock listed?

SYRE stock is listed on the Nasdaq exchange.


What is the price forecast or stock price prediction for SPYRE THERAPEUTICS INC stock?

18 analysts have analysed SYRE and the average price target is 55.42 USD. This implies a price increase of 247.68% is expected in the next year compared to the current price of 15.94. Check the SPYRE THERAPEUTICS INC stock analysts ratings, price target forecast and up-and down grades for more detailed information.


What is SPYRE THERAPEUTICS INC worth?

SPYRE THERAPEUTICS INC (SYRE) has a market capitalization of 962.78M USD. This makes SYRE a Small Cap stock.


How many employees does SPYRE THERAPEUTICS INC have?

SPYRE THERAPEUTICS INC (SYRE) currently has 65 employees.


What are the support and resistance levels for SPYRE THERAPEUTICS INC (SYRE) stock?

SPYRE THERAPEUTICS INC (SYRE) has a support level at 16.41 and a resistance level at 16.78. Check the full technical report for a detailed analysis of SYRE support and resistance levels.


Is SPYRE THERAPEUTICS INC (SYRE) expected to grow?

The Revenue of SPYRE THERAPEUTICS INC (SYRE) is expected to decline by -100% in the next year. Check the estimates tab for more information on the SYRE EPS, Sales, EBIT and EBITDA future analyst estimates.


Should I buy SPYRE THERAPEUTICS INC (SYRE) stock?

There is no straightforward answer here. It depends on your investment strategy as different types of investors will look at different aspects. In any case it is important to make an informed decision and these pages can help you forming an opinion:


Does SPYRE THERAPEUTICS INC (SYRE) stock pay dividends?

SYRE does not pay a dividend.


When does SPYRE THERAPEUTICS INC (SYRE) report earnings?

SPYRE THERAPEUTICS INC (SYRE) will report earnings on 2025-11-05, after the market close.


What is the Price/Earnings (PE) ratio of SPYRE THERAPEUTICS INC (SYRE)?

SPYRE THERAPEUTICS INC (SYRE) does not have a PE ratio as the earnings reported over the last twelve months were negative (-3.54).


What is the Short Interest ratio of SPYRE THERAPEUTICS INC (SYRE) stock?

The outstanding short interest for SPYRE THERAPEUTICS INC (SYRE) is 25.74% of its float. Check the ownership tab for more information on the SYRE short interest.


SYRE Technical Analysis

ChartMill assigns a technical rating of 2 / 10 to SYRE. When comparing the yearly performance of all stocks, SYRE is a bad performer in the overall market: 88.32% of all stocks are doing better.


Chartmill TA Rating
Chartmill Setup Rating

SYRE Fundamental Analysis

ChartMill assigns a fundamental rating of 3 / 10 to SYRE. SYRE has a great financial health rating, but its profitability evaluates not so good.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

SYRE Financial Highlights

Over the last trailing twelve months SYRE reported a non-GAAP Earnings per Share(EPS) of -3.54. The EPS increased by 77.09% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -34.19%
ROE -40.17%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%10.47%
Sales Q2Q%N/A
EPS 1Y (TTM)77.09%
Revenue 1Y (TTM)-100%

SYRE Forecast & Estimates

18 analysts have analysed SYRE and the average price target is 55.42 USD. This implies a price increase of 247.68% is expected in the next year compared to the current price of 15.94.

For the next year, analysts expect an EPS growth of 30.65% and a revenue growth -100% for SYRE


Analysts
Analysts88.89
Price Target55.42 (247.68%)
EPS Next Y30.65%
Revenue Next Year-100%

SYRE Ownership

Ownership
Inst Owners104.27%
Ins Owners8.7%
Short Float %25.74%
Short Ratio24.52