Logo image of SPRB

SPRUCE BIOSCIENCES INC (SPRB) Stock Price, Forecast & Analysis

USA - NASDAQ:SPRB - US85209E2081 - Common Stock

115 USD
+6.17 (+5.66%)
Last: 11/18/2025, 8:00:03 PM
118 USD
+3 (+2.61%)
After Hours: 11/18/2025, 8:00:03 PM

SPRB Key Statistics, Chart & Performance

Key Statistics
Market Cap64.40M
Revenue(TTM)4.91M
Net Income(TTM)-48.34M
Shares560.00K
Float550.00K
52 Week High240
52 Week Low0.08
Yearly DividendN/A
Dividend YieldN/A
EPS(TTM)-84.83
PEN/A
Fwd PEN/A
Earnings (Next)04-13 2026-04-13/amc
IPO2020-10-09
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology


SPRB short term performance overview.The bars show the price performance of SPRB in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 0 10K 20K 30K 40K

SPRB long term performance overview.The bars show the price performance of SPRB in the last 1, 2 and 3 years. 1 year 2 years 3 years 5K 10K 15K 20K

The current stock price of SPRB is 115 USD. In the past month the price decreased by -11.22%. In the past year, price increased by 20015.4%.

SPRUCE BIOSCIENCES INC / SPRB Daily stock chart

SPRB Latest News, Press Relases and Analysis

SPRB Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
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TA
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PE
Market Cap
ABBV ABBVIE INC 24.75 413.15B
AMGN AMGEN INC 15.73 185.19B
GILD GILEAD SCIENCES INC 15.53 157.81B
VRTX VERTEX PHARMACEUTICALS INC 25.09 111.66B
REGN REGENERON PHARMACEUTICALS 16.12 76.88B
ALNY ALNYLAM PHARMACEUTICALS INC 906.47 60.60B
INSM INSMED INC N/A 42.62B
NTRA NATERA INC N/A 29.32B
BIIB BIOGEN INC 10.09 24.75B
UTHR UNITED THERAPEUTICS CORP 18.06 21.56B
INCY INCYTE CORP 16.18 20.29B
NBIX NEUROCRINE BIOSCIENCES INC 33.17 13.75B

About SPRB

Company Profile

SPRB logo image Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company is headquartered in South San Francisco, California and currently employs 9 full-time employees. The company went IPO on 2020-10-09. The firm has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The firm's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.

Company Info

SPRUCE BIOSCIENCES INC

611 Gateway Boulevard, Suite 740

South San Francisco CALIFORNIA 94104 US

CEO: Richard King

Employees: 9

SPRB Company Website

SPRB Investor Relations

Phone: 14156554168

SPRUCE BIOSCIENCES INC / SPRB FAQ

Can you describe the business of SPRUCE BIOSCIENCES INC?

Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company is headquartered in South San Francisco, California and currently employs 9 full-time employees. The company went IPO on 2020-10-09. The firm has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The firm's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.


What is the current price of SPRB stock?

The current stock price of SPRB is 115 USD. The price increased by 5.66% in the last trading session.


Does SPRB stock pay dividends?

SPRB does not pay a dividend.


What is the ChartMill rating of SPRUCE BIOSCIENCES INC stock?

SPRB has a ChartMill Technical rating of 7 out of 10 and a ChartMill Fundamental rating of 2 out of 10.


What is the Price/Earnings (PE) ratio of SPRUCE BIOSCIENCES INC (SPRB)?

SPRUCE BIOSCIENCES INC (SPRB) does not have a PE ratio as the earnings reported over the last twelve months were negative (-84.83).


Can you provide the growth outlook for SPRUCE BIOSCIENCES INC?

The Revenue of SPRUCE BIOSCIENCES INC (SPRB) is expected to decline by -100% in the next year. Check the estimates tab for more information on the EPS, Sales, EBIT and EBITDA future analyst estimates.


What is the next earnings date for SPRB stock?

SPRUCE BIOSCIENCES INC (SPRB) will report earnings on 2026-04-13, after the market close.


SPRB Technical Analysis

ChartMill assigns a technical rating of 7 / 10 to SPRB. When comparing the yearly performance of all stocks, SPRB is one of the better performing stocks in the market, outperforming 100% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating

SPRB Fundamental Analysis

ChartMill assigns a fundamental rating of 2 / 10 to SPRB. SPRB scores quite bad on profitability, while its financial health is fine. Not spectacular, but in line with the averages.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend

SPRB Financial Highlights

Over the last trailing twelve months SPRB reported a non-GAAP Earnings per Share(EPS) of -84.83. The EPS decreased by -158.86% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -221.53%
ROE -366.75%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%7.43%
Sales Q2Q%-100%
EPS 1Y (TTM)-158.86%
Revenue 1Y (TTM)-51.32%

SPRB Forecast & Estimates

8 analysts have analysed SPRB and the average price target is 137.19 USD. This implies a price increase of 19.3% is expected in the next year compared to the current price of 115.

For the next year, analysts expect an EPS growth of 70.16% and a revenue growth -100% for SPRB


Analysts
Analysts80
Price Target137.19 (19.3%)
EPS Next Y70.16%
Revenue Next Year-100%

SPRB Ownership

Ownership
Inst Owners21.05%
Ins Owners2.32%
Short Float %22.11%
Short Ratio0.11