SPRUCE BIOSCIENCES INC (SPRB) Stock Price & Overview

NASDAQ:SPRB • US85209E2081

55.87 USD
+2.09 (+3.89%)
At close: Mar 6, 2026
58 USD
+2.13 (+3.81%)
After Hours: 3/6/2026, 8:00:02 PM

The current stock price of SPRB is 55.87 USD. Today SPRB is up by 3.89%. In the past month the price decreased by -21.14%. In the past year, price increased by 10664.9%.

SPRB Key Statistics

52-Week Range0.0779 - 240
Current SPRB stock price positioned within its 52-week range.
1-Month Range48.08 - 86.945
Current SPRB stock price positioned within its 1-month range.
Market Cap
59.781M
P/E
N/A
Fwd P/E
N/A
EPS (TTM)
-84.83
Dividend Yield
N/A

SPRB Stock Performance

Today
+3.89%
1 Week
+1.69%
1 Month
-21.14%
3 Months
-30.15%
Longer-term
6 Months +46,968.20%
1 Year +10,664.90%
2 Years +3,890.71%
3 Years +4,979.09%
5 Years +95.01%
10 Years N/A

SPRB Stock Chart

SPRUCE BIOSCIENCES INC / SPRB Daily stock chart

SPRB Technical Analysis

ChartMill assigns a technical rating of 2 / 10 to SPRB. When comparing the yearly performance of all stocks, SPRB is one of the better performing stocks in the market, outperforming 99.99% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating
SPRB Full Technical Analysis Report

SPRB Fundamental Analysis

ChartMill assigns a fundamental rating of 1 / 10 to SPRB. The financial health of SPRB is average, but there are quite some concerns on its profitability.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend
SPRB Full Fundamental Analysis Report

SPRB Earnings

Next Earnings DateApr 13, 2026
Last Earnings DateNov 10, 2025
PeriodQ3 / 2025
EPS Reported-$14.58
Revenue Reported
EPS Surprise -2.58%
Revenue Surprise %
SPRB Earnings History

SPRB Forecast & Estimates

10 analysts have analysed SPRB and the average price target is 209.87 USD. This implies a price increase of 275.63% is expected in the next year compared to the current price of 55.87.

For the next year, analysts expect an EPS growth of 77.01% and a revenue growth -100% for SPRB


Analysts
Analysts86
Price Target209.87 (275.64%)
EPS Next Y77.01%
Revenue Next Year-100%
SPRB Forecast & Estimates

SPRB Groups

Sector & Classification

Sub-Industry
Biotechnology
Index Membership

SPRB Financial Highlights

Over the last trailing twelve months SPRB reported a non-GAAP Earnings per Share(EPS) of -84.83. The EPS decreased by -19.06% compared to the year before.


Income Statements
Revenue(TTM)697.00K
Net Income(TTM)-47.88M
Industry RankSector Rank
PM (TTM) N/A
ROA -312.67%
ROE -888.95%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%7.43%
Sales Q2Q%-100%
EPS 1Y (TTM)-19.06%
Revenue 1Y (TTM)-90.18%
SPRB financials

SPRB Ownership

Ownership
Inst Owners86.75%
Shares1.07M
Float970.00K
Ins Owners9.24%
Short Float %8.04%
Short Ratio1.99
SPRB Ownership

SPRB Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
SymbolCompany NameTechnical RatingFundamental RatingFPEMarket Cap
ABBV ABBVIE INC15.85410.651B
AMGN AMGEN INC16.4197.945B
GILD GILEAD SCIENCES INC16.14180.072B
VRTX VERTEX PHARMACEUTICALS INC22.4116.919B
REGN REGENERON PHARMACEUTICALS16.3680.868B
ALNY ALNYLAM PHARMACEUTICALS INC47.8742.343B
INSM INSMED INC N/A30.619B
NTRA NATERA INC N/A27.941B
BIIB BIOGEN INC12.1527.603B
UTHR UNITED THERAPEUTICS CORP16.0121.26B
MRNA MODERNA INC N/A21.03B
RVMD REVOLUTION MEDICINES INC N/A19.746B
EXAS EXACT SCIENCES CORP309.3619.715B

About SPRB

Company Profile

SPRB logo image Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company is headquartered in South San Francisco, California and currently employs 9 full-time employees. The company went IPO on 2020-10-09. The firm has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The firm's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.

Company Info

SPRUCE BIOSCIENCES INC

611 Gateway Boulevard, Suite 740

South San Francisco CALIFORNIA 94104 US

CEO: Richard King

Employees: 9

SPRB Company Website

SPRB Investor Relations

Phone: 14156554168

SPRUCE BIOSCIENCES INC / SPRB FAQ

Can you describe the business of SPRUCE BIOSCIENCES INC?

Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company is headquartered in South San Francisco, California and currently employs 9 full-time employees. The company went IPO on 2020-10-09. The firm has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The firm's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.


Can you provide the latest stock price for SPRUCE BIOSCIENCES INC?

The current stock price of SPRB is 55.87 USD. The price increased by 3.89% in the last trading session.


Does SPRB stock pay dividends?

SPRB does not pay a dividend.


What is the ChartMill technical and fundamental rating of SPRB stock?

SPRB has a ChartMill Technical rating of 2 out of 10 and a ChartMill Fundamental rating of 1 out of 10.


How is the valuation of SPRUCE BIOSCIENCES INC (SPRB) based on its PE ratio?

SPRUCE BIOSCIENCES INC (SPRB) does not have a PE ratio as the earnings reported over the last twelve months were negative (-84.83).


Is SPRUCE BIOSCIENCES INC (SPRB) stock a good buy?

This depends on your investment goals. Check the Technical and Fundamental Analysis tabs for insights on SPRB.


What is the next earnings date for SPRB stock?

SPRUCE BIOSCIENCES INC (SPRB) will report earnings on 2026-04-13, after the market close.