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Which stocks are moving before the opening bell on Wednesday?

By Mill Chart

Last update: Dec 7, 2022

Let's have a look at what is happening on the US markets before the opening bell on Wednesday. Below you can find the top gainers and losers in today's pre-market session.

Gainers

TickerChangeComment
RXDX188.0%PROMETHEUS BIOSCIENCES INC's (NASDAQ:RXDX) shares rose 188.0% to $103.9. Earlier today the company had a press release: Prometheus Biosciences Announces Positive Results for PRA023 in Both ARTEMIS-UC Phase 2 and APOLLO-CD Phase 2a Studies Enabling Pathway to Both First-in-Class and Best-in-Class Anti-TL1A mAb.
RNAZ68.39%TRANSCODE THERAPEUTICS INC's (NASDAQ:RNAZ) stock price increased by 68.39% to $0.71. Yesterday the company had a press release: TransCode Therapeutics Announces Withdrawal of Registration Statement.
REPL34.94%REPLIMUNE GROUP INC's (NASDAQ:REPL) shares rose 34.94% to $25.49. Shareholders saw the stock price going 21.4% higher is the past 6 months.
QRTEB32.79%QURATE RETAIL GROUP INC-B's (NASDAQ:QRTEB) shares rose 32.79% to $8.99 during Wednesday's pre-market session. In the last month the stock gained 34.06%.
MDB25.86%MONGODB INC's (NASDAQ:MDB) shares rose 25.86% to $182.1 during Wednesday's pre-market session. Shareholders saw the stock price going 46.14% lower in the past 3 months.
ESPR24.19%ESPERION THERAPEUTICS INC's (NASDAQ:ESPR) shares rose 24.19% to $9.24 during Wednesday's pre-market session. In the last 6 months the stock gained 36.01%.
MMAT22.54%META MATERIALS INC's (NASDAQ:MMAT) stock price is advancing with 22.54% to a price of $2.39. This is a continuation of yesterday's gain of 14.04%.
LTRYW20.0%LOTTERY.COM -CW21 (NASDAQ:LTRYW) rose 20.0% to $0.02 during Wednesday's pre-market session. The stock is trading 44.44% lower than a month ago.
ENTX17.68%ENTERA BIO LTD's (NASDAQ:ENTX) shares rose 17.68% to $0.77. In the last 3 months the share price dropped with 52.93%.
VGFC17.63%VERY GOOD FOOD CO INC/THE's (NASDAQ:VGFC) shares rose 17.63% to $0.09 during Wednesday's pre-market session. Prices are quite volatile here as yesterday NASDAQ:VGFC closed with a -18.03% loss.

To see the full list of premarket gainers you can use our premarket gainers screener.

Pre-market losers

TickerChangeComment
IBIO-51.88%IBIO INC's (NYSEARCA:IBIO) shares fell 51.88% to $0.77. Shareholders saw the stock price going 77.4% lower in the past 3 months.
ENSC-49.78%ENSYSCE BIOSCIENCES INC's (NASDAQ:ENSC) stock price decreased by 49.78% to $1.12. The stock is trading 551.0% higher than 3 months ago.
VS-41.74%VERSUS SYSTEMS INC's (NASDAQ:VS) stock price is declining with 41.74% to a price of $0.87. A press release (Versus Systems Announces Pricing of $2.1 Million Public Offering) was released earlier today.
WBEV-28.55%WINC INC's (NYSEARCA:WBEV) stock price is declining with 28.55% to a price of $0.25. NYSEARCA:WBEV already had a hard day yesterday: closing -15.52% lower during the regular session.
CVNA-23.25%CARVANA CO's (NYSE:CVNA) shares fell 23.25% to $5.15. Shareholders saw the stock price going 81.68% lower in the past 3 months.
PAFO-18.43%PACIFICO ACQUISTION CORP's (NASDAQ:PAFO) shares fell 18.43% to $6.55. After yesterdays gain of 59.01%, it goes down with 18.43% in today's pre-market session. A press release (Pacifico Acquisition Corp. Stockholders Approve Proposed Merger Transaction with Caravelle) was released two days ago.
CTRM-15.38%CASTOR MARITIME INC's (NASDAQ:CTRM) stock price decreased by 15.38% to $1.32. In the last month the stock gained 32.2%.
COSM-15.14%COSMOS HOLDINGS INC's (NASDAQ:COSM) stock price is declining with 15.14% to a price of $0.4. NASDAQ:COSM already had a hard day yesterday: closing -17.39% lower during the regular session.
DUO-12.7%FANGDD NETWORK GROUP LTD-ADR's (NASDAQ:DUO) shares fell 12.7% to $1.1 during Wednesday's pre-market session. The stock is trading 59.35% lower than 6 months ago.
XFOR-12.5%X4 PHARMACEUTICALS INC's (NASDAQ:XFOR) shares fell 12.5% to $1.05 during Wednesday's pre-market session. Shareholders saw the stock price going 33.33% lower in the past month.

To see the full list of premarket losers you can use our premarket losers screener.

IBIO INC

NASDAQ:IBIO (1/7/2026, 10:25:53 AM)

2.11

+0.05 (+2.43%)


ESPERION THERAPEUTICS INC

NASDAQ:ESPR (1/7/2026, 10:26:09 AM)

3.835

+0.11 (+3.09%)


PROMETHEUS BIOSCIENCES INC

NASDAQ:RXDX (6/15/2023, 8:23:19 PM)

After market: 199.95 +0.03 (+0.02%)

199.92

+0.18 (+0.09%)


MONGODB INC

NASDAQ:MDB (1/7/2026, 10:25:34 AM)

437.76

+1.9 (+0.44%)


ENTERA BIO LTD

NASDAQ:ENTX (1/7/2026, 10:26:06 AM)

1.59

+0.02 (+1.27%)


QURATE RETAIL GROUP INC-B

NASDAQ:QRTEB (2/21/2025, 8:00:01 PM)

After market: 2.44 +0.44 (+22%)

2

-0.02 (-0.99%)


REPLIMUNE GROUP INC

NASDAQ:REPL (1/7/2026, 10:25:44 AM)

8.46

+0.01 (+0.12%)


CASTOR MARITIME INC

NASDAQ:CTRM (1/7/2026, 10:25:35 AM)

2.16

+0.01 (+0.47%)


X4 PHARMACEUTICALS INC

NASDAQ:XFOR (1/7/2026, 10:25:43 AM)

4.005

+0.04 (+1.14%)


FANGDD NETWORK GROUP LTD-A

NASDAQ:DUO (1/7/2026, 10:26:01 AM)

1.52

-0.13 (-7.88%)


VERSUS SYSTEMS INC

NASDAQ:VS (1/7/2026, 10:23:43 AM)

1.28

-0.03 (-2.29%)


TRANSCODE THERAPEUTICS INC

NASDAQ:RNAZ (1/7/2026, 10:24:56 AM)

7.46

+0.1 (+1.36%)


META MATERIALS INC

NASDAQ:MMAT (8/20/2024, 8:00:00 PM)

After market: 0.5013 -0.02 (-4.66%)

0.5258

-0.11 (-17.84%)


ENSYSCE BIOSCIENCES INC

NASDAQ:ENSC (1/7/2026, 10:24:33 AM)

1

-0.01 (-0.99%)


PACIFICO ACQUISTION CORP

NASDAQ:PAFO (12/16/2022, 8:18:34 PM)

After market: 6.05 +1.85 (+44.05%)

4.2

-3.7 (-46.84%)


VERY GOOD FOOD CO INC/THE

NASDAQ:VGFC (1/20/2023, 8:10:30 PM)

After market: 0.0371 -0.01 (-27.96%)

0.0515

0 (-1.9%)


LOTTERY.COM -CW21

NASDAQ:LTRYW (1/7/2026, 10:20:04 AM)

0.0081

0 (-2.41%)


WINC INC

NYSEARCA:WBEV (12/12/2022, 8:22:15 PM)

After market: 0.14 0 (0%)

0.14

-0.03 (-20%)


CARVANA CO

NYSE:CVNA (1/7/2026, 10:26:01 AM)

443.8

+3.36 (+0.76%)


COSMOS HEALTH INC

NASDAQ:COSM (1/7/2026, 10:25:49 AM)

0.52

-0.02 (-3.26%)



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