NanoVibronix Announces Results from UroShield™ Case Series

NanoVibronix, Inc. (NASDAQ: NAOV) (the “Company”), a medical technology company specializing in therapeutic devices, today announced findings from a recent retrospective case series evaluating the clinical impact and patient experience of the UroShield™ system.

The case series, conducted between September 2023 and January 2025 by researchers at University Hospitals Coventry and Warwickshire Partnership NHS, assessed a small group of patients who used the UroShield device for durations ranging from 12 weeks to 17 months. The series reviewed pre- and post-treatment data on catheter-associated urinary tract infections (CAUTIs), catheter blockages, unplanned hospital visits and patient satisfaction.

Key Outcomes of the Case Series Included:

• a 94% average reduction in CAUTIs and catheter blockages;
• a 92% decrease in unplanned hospital visits;
• extended intervals between catheter changes, improving patient comfort and quality of life;
• high patient compliance and satisfaction; and
• only one patient discontinued due to worsening of pre-existing bladder symptoms.

Importantly, these outcomes reinforce the results from previous studies, including those by Markowitz et al. (2018)¹ and Da Silva, Ibbotson, and O’Neil (2021)², which demonstrated the effectiveness of UroShield in reducing infection risk, improving catheter management, and enhancing overall patient outcomes.

“We believe that this case series reinforces the growing body of clinical evidence supporting UroShield as an effective solution for minimizing catheter-associated risks, improving patient care and the quality of life for patients living with long-term catheterization while reducing healthcare burden,” said Brian Murphy, CEO of NanoVibronix, Inc. “The results of this series are another strong affirmation of the device’s value for both patient care and healthcare cost reduction.”

UroShield utilizes proprietary Surface Acoustic Wave (SAW) technology to prevent bacterial colonization and biofilm formation on indwelling urinary catheters, a critical advancement in reducing complications such as CAUTIs.

The case series will be presented on May 19, 2025, at the Association for Continence Professionals annual conference, ACP 2025. For additional information about the conference, please visit https://fitwise.eventsair.com/acp2025/.

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1 Markowitz. S., Rosenblum. J., Goldstein. M., Gadagkar. H.P., and Litman. L. (2018) The effect of surface acoustic waves on bacterial load and preventing catheter-associated urinary tract infections (CAUTI) in long term indwelling catheters

2 Da Silva. K., Ibbotson. A., and O’Neil. M. (2021) The effectiveness of UroShield in reducing urinary tract infections and patients’ pain complaints: Retrospective Data Analysis from Clinical Practice.

About NanoVibronix, Inc.

NanoVibronix, Inc. (NASDAQ: NAOV) is a medical device company headquartered in Tyler, Texas, with research and development in Nesher, Israel, focused on developing medical devices utilizing its patented low intensity surface acoustic wave (SAW) technology. The proprietary technology allows for the creation of low-frequency ultrasound waves that can be utilized for a variety of medical applications, including for disruption of biofilms and bacterial colonization, as well as for pain relief. The devices can be administered at home without the continuous assistance of medical professionals. The Company’s primary products include PainShield® and UroShield®, which are portable devices suitable for administration at home or in any care setting. Additional information about NanoVibronix is available at: www.nanovibronix.com.

Forward-looking Statements

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