SPERO THERAPEUTICS INC (SPRO) Stock Price, Forecast & Analysis

NASDAQ:SPRO • US84833T1034

2.22 USD
-0.01 (-0.45%)
At close: Feb 25, 2026
2.2004 USD
-0.02 (-0.88%)
Pre-Market: 2/26/2026, 8:19:35 AM

SPRO Key Statistics, Chart & Performance

Key Statistics
Market Cap125.07M
Revenue(TTM)40.55M
Net Income(TTM)-43.84M
Shares56.34M
Float43.27M
52 Week High3.22
52 Week Low0.51
Yearly DividendN/A
Dividend Yield0%
EPS(TTM)-0.79
PEN/A
Fwd PE3.25
Earnings (Next)03-25
IPO2017-11-02
Sector
GICS SectorHealth Care
GICS IndustryBiotechnology
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS SubIndustryBiotechnology
SPRO short term performance overview.The bars show the price performance of SPRO in the last week, last 2 weeks, last month, last 3 and 6 months. 1 week 2 week 1 month 3 months 6 months 0 5 -5

SPRO long term performance overview.The bars show the price performance of SPRO in the last 1, 2 and 3 years. 1 year 2 years 3 years 50 100 150

The current stock price of SPRO is 2.22 USD. In the past month the price decreased by -6.33%. In the past year, price increased by 186.23%.

SPERO THERAPEUTICS INC / SPRO Daily stock chart

SPRO Technical Analysis

ChartMill assigns a technical rating of 2 / 10 to SPRO. When comparing the yearly performance of all stocks, SPRO is one of the better performing stocks in the market, outperforming 95.6% of all stocks.


Chartmill TA Rating
Chartmill Setup Rating
SPRO Full Technical Analysis Report

SPRO Fundamental Analysis

ChartMill assigns a fundamental rating of 4 / 10 to SPRO. The financial health of SPRO is average, but there are quite some concerns on its profitability.


Chartmill FA Analysis
Valuation
Growth
Profitability
Health
Dividend
SPRO Full Fundamental Analysis Report

SPRO Financial Highlights

Over the last trailing twelve months SPRO reported a non-GAAP Earnings per Share(EPS) of -0.79. The EPS decreased by -1228.57% compared to the year before.


Industry RankSector Rank
PM (TTM) N/A
ROA -80.92%
ROE -165.46%
Debt/Equity 0
Chartmill High Growth Momentum
EPS Q2Q%59.38%
Sales Q2Q%-59.6%
EPS 1Y (TTM)-1228.57%
Revenue 1Y (TTM)-61.91%
SPRO financials

SPRO Forecast & Estimates

6 analysts have analysed SPRO and the average price target is 4.08 USD. This implies a price increase of 83.78% is expected in the next year compared to the current price of 2.22.

For the next year, analysts expect an EPS growth of 91.97% and a revenue growth -34.56% for SPRO


Analysts
Analysts43.33
Price Target4.08 (83.78%)
EPS Next Y91.97%
Revenue Next Year-34.56%
SPRO Analyst EstimatesSPRO Analyst Ratings

SPRO Ownership

Ownership
Inst Owners16.1%
Ins Owners2.43%
Short Float %2.18%
Short Ratio3.31
SPRO Ownership

SPRO Competitors/Peers

The largest stocks on the US markets in the "Biotechnology" sub-industry
Full List
SymbolCompany NameTechnical RatingFundamental RatingFPEMarket Cap
ABBV ABBVIE INC15.63401.054B
AMGN AMGEN INC17.06206.954B
GILD GILEAD SCIENCES INC16.49182.529B
VRTX VERTEX PHARMACEUTICALS INC23.69122.559B
REGN REGENERON PHARMACEUTICALS16.8882.914B
ALNY ALNYLAM PHARMACEUTICALS INC48.8743.248B
INSM INSMED INC N/A31.694B
NTRA NATERA INC N/A29.474B
BIIB BIOGEN INC12.5427.992B
UTHR UNITED THERAPEUTICS CORP18.1623.041B

About SPRO

Company Profile

SPRO logo image Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which focuses on identifying, developing, and commercializing treatments involving bacterial infections, including multi-drug resistant bacterial infections, and rare diseases Its pipeline product candidates include Tebipenem HBr, SPR720, and SPR206. The company is headquartered in Cambridge, Massachusetts and currently employs 32 full-time employees. The company went IPO on 2017-11-02. The firm is focused on identifying and developing novel treatments for rare diseases and diseases caused by multi-drug resistant (MDR) bacterial infections with unmet need. Its product candidate SPR720 is an investigational, chemically stable phosphate ester prodrug that is converted in vivo to SPR719 for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease. Its clinical stage product candidate, tebipenem HBr is an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections (cUTIs) including acute pyelonephritis (AP) to help patients potentially reduce duration of in-patient therapy.

Company Info

SPERO THERAPEUTICS INC

675 Massachusetts Ave Ste 14

Cambridge MASSACHUSETTS 02139 US

CEO: Ankit Mahadevia

Employees: 32

SPRO Company Website

SPRO Investor Relations

Phone: 18572421600

SPERO THERAPEUTICS INC / SPRO FAQ

What does SPERO THERAPEUTICS INC do?

Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which focuses on identifying, developing, and commercializing treatments involving bacterial infections, including multi-drug resistant bacterial infections, and rare diseases Its pipeline product candidates include Tebipenem HBr, SPR720, and SPR206. The company is headquartered in Cambridge, Massachusetts and currently employs 32 full-time employees. The company went IPO on 2017-11-02. The firm is focused on identifying and developing novel treatments for rare diseases and diseases caused by multi-drug resistant (MDR) bacterial infections with unmet need. Its product candidate SPR720 is an investigational, chemically stable phosphate ester prodrug that is converted in vivo to SPR719 for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease. Its clinical stage product candidate, tebipenem HBr is an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections (cUTIs) including acute pyelonephritis (AP) to help patients potentially reduce duration of in-patient therapy.


Can you provide the latest stock price for SPERO THERAPEUTICS INC?

The current stock price of SPRO is 2.22 USD. The price decreased by -0.45% in the last trading session.


Does SPRO stock pay dividends?

SPRO does not pay a dividend.


How is the ChartMill rating for SPERO THERAPEUTICS INC?

SPRO has a ChartMill Technical rating of 2 out of 10 and a ChartMill Fundamental rating of 4 out of 10.


Can you provide the sector and industry classification for SPERO THERAPEUTICS INC?

SPERO THERAPEUTICS INC (SPRO) operates in the Health Care sector and the Biotechnology industry.


Can you provide the upcoming earnings date for SPERO THERAPEUTICS INC?

SPERO THERAPEUTICS INC (SPRO) will report earnings on 2026-03-25, after the market close.


What is the Short Interest ratio of SPERO THERAPEUTICS INC (SPRO) stock?

The outstanding short interest for SPERO THERAPEUTICS INC (SPRO) is 2.18% of its float.