These S&P500 stocks that are showing activity before the opening bell on Wednesday.

Last update: Oct 22, 2025

As we await the opening of the US market on Wednesday, let's delve into the pre-market session and discover the S&P500 top gainers and losers shaping the early market sentiment.

Today's pre-market gainers

Ticker	Change	Comment
ISRG	18.95%	INTUITIVE SURGICAL INC (NASDAQ:ISRG) rose 18.95% to $550.41 during Wednesday's pre-market session. Yesterday the company had a press release: Intuitive Announces Third Quarter Earnings.
APH	8.89%	AMPHENOL CORP-CL A's (NYSE:APH) stock price increased by 8.89% to $135.5. yesterday the company released their earnings. Earlier today the company had a press release: Amphenol Reports Record Third Quarter 2025 Results and Announces Dividend Increase.
COF	4.36%	During Wednesday's pre-market trading, CAPITAL ONE FINANCIAL CORP (NYSE:COF) demonstrated strong momentum, with the stock price rising 4.36% to $226.51. A press release (Capital One Reports Third Quarter 2025 Net Income of $3.2 billion, or $4.83 per share) was released yesterday.
GEV	3.87%	GE VERNOVA INC's (NYSE:GEV) shares rose 3.87% to $607.98 during Wednesday's pre-market session. GE VERNOVA INC released earnings Yesterday. Yesterday the company had a press release: GE Vernova to Fully Acquire Prolec GE Joint Venture.
WBD	2.8%	WARNER BROS DISCOVERY INC (NASDAQ:WBD) rose 2.8% to $20.9 during Wednesday's pre-market session. After recording a 10.97% gain in the previous session, WBD maintains its positive trajectory in today's pre-market, with an additional 2.8% increase.
HLT	2.31%	HILTON WORLDWIDE HOLDINGS IN (NYSE:HLT) experienced an impressive 2.31% increase in share price, reaching $272.11 during the pre-market session on Wednesday. The company's earnings where released Yesterday. A press release (AI, Robotics Power Expansion and Uplisting Momentum Across Emerging Markets) was released earlier today.
GOOG	2.25%	Investors witnessed a remarkable surge in ALPHABET INC-CL C (NASDAQ:GOOG) during Wednesday's pre-market session, with the stock price rising 2.25% to $257.0. In the last 3 months the share price increased with 29.5%.
GOOGL	2.23%	ALPHABET INC-CL A's (NASDAQ:GOOGL) shares rose 2.23% to $256.04. Shareholders saw the stock price going 29.65% higher in the past 3 months.
LII	2.19%	Exciting news for LENNOX INTERNATIONAL INC (NYSE:LII) as their shares soared 2.19% to $561.0 during the pre-market session on Wednesday. yesterday the company released their earnings.
TMO	2.15%	THERMO FISHER SCIENTIFIC INC's (NYSE:TMO) shares surged 2.15% to reach $570.0 during the pre-market session on Wednesday. yesterday the company released their earnings. A press release (Thermo Fisher Scientific Reports Third Quarter 2025 Results) was released earlier today.

To see the full list of premarket gainers you can use our premarket gainers page.

Today's pre-market losers

Ticker	Change	Comment
TXN	-7.93%	TEXAS INSTRUMENTS INC's (NASDAQ:TXN) shares fell 7.93% to $166.5 during Wednesday's pre-market session.
NFLX	-7.66%	The pre-market session on Wednesday witnessed a 7.66% decrease in NETFLIX INC's (NASDAQ:NFLX) shares, with the stock price falling to $1.15K. In the last year the stock gained 64.49%.
NEM	-4.54%	Investors observed a 4.54% decline in NEWMONT CORP's (NYSE:NEM) stock price, which now stands at $82.4 during Wednesday's pre-market session. NEWMONT CORP is releasing earnings today. In the last 3 months the share price increased with 31.29%.
WYNN	-4.37%	During Wednesday's pre-market session, the shares of WYNN RESORTS LTD (NASDAQ:WYNN) declined by 4.37%, reaching $115.84. In the last 6 months the stock gained 47.52%.
HPQ	-2.91%	During Wednesday's pre-market session, the shares of HP INC (NYSE:HPQ) declined by 2.91%, reaching $27.34. Shareholders saw the stock price going 23.64% lower is the past year.
MCHP	-2.7%	Investors observed a 2.7% decline in MICROCHIP TECHNOLOGY INC's (NASDAQ:MCHP) stock price, which now stands at $65.7 during Wednesday's pre-market session. In the last 6 months the share price increased with 44.0%.
TDY	-2.4%	TELEDYNE TECHNOLOGIES INC's (NYSE:TDY) stock price recorded a 2.4% decrease, falling to $560.0. TELEDYNE TECHNOLOGIES INC released earnings Yesterday. A press release (Teledyne Technologies Reports Third Quarter Results) was released earlier today.
ADI	-2.17%	ANALOG DEVICES INC's (NASDAQ:ADI) stock price is declining with 2.17% to a price of $241.02. Yesterday the company had a press release: ASE and Analog Devices Announce Strategic Collaboration.
COIN	-2.07%	COINBASE GLOBAL INC -CLASS A's (NASDAQ:COIN) shares experienced a 2.07% decline, falling to $331.61 during Wednesday's pre-market session. The stock is trading 61.52% higher than 6 months ago.
ON	-2.05%	ON SEMICONDUCTOR's (NASDAQ:ON) shares experienced a 2.05% decline, falling to $53.95 during Wednesday's pre-market session. Shareholders saw the stock price going 38.99% higher is the past 6 months.