Wednesday's session: top gainers and losers in the S&P500 index
By Mill Chart
Last update: Oct 1, 2025
Let's have a look at the top S&P500 gainers and losers one hour before the close of the markets of today's session.
Today's top gainers
| Ticker | Change | Comment |
|---|---|---|
| AES | 16.23% | Investors celebrated as AES CORP (NYSE:AES) experienced a 16.23% rise in its shares, closing at $15.3 during Wednesday's session. The stock is trading 22.08% higher than 6 months ago. |
| TMO | 9.61% | THERMO FISHER SCIENTIFIC INC's (NYSE:TMO) shares soared 9.61% to $531.61 during Wednesday's session. Yesterday the company had a press release: Thermo Fisher Scientific Prices Offering of USD-Denominated Senior Notes. |
| BIIB | 8.94% | Exciting news for BIOGEN INC (NASDAQ:BIIB) as its stock price surged 8.94% to $152.6 during Wednesday's session. In the last year the stock lost 24.56%. |
| LLY | 8.51% | Positive market sentiment drove ELI LILLY & CO's (NYSE:LLY) stock price up by 8.51% to $827.91 during Wednesday's session. |
| CRL | 8.26% | CHARLES RIVER LABORATORIES (NYSE:CRL) rose 8.26% to $169.38 during Wednesday's after hours session. |
| MRNA | 8.09% | MODERNA INC's (NASDAQ:MRNA) shares rose 8.09% to $27.92. The stock is trading 57.09% lower than a year ago. |
| MRK | 7.9% | MERCK & CO. INC.'s (NYSE:MRK) stock price is advancing with 7.9% to a price of $90.56. Shareholders saw the stock price going 23.54% lower is the past year. |
| DDOG | 7.72% | DATADOG INC - CLASS A's (NASDAQ:DDOG) shares rose 7.72% to $153.39 during Wednesday's session. Shareholders saw the stock price going 61.95% higher is the past 6 months. |
| STX | 7.62% | SEAGATE TECHNOLOGY HOLDINGS's (NASDAQ:STX) shares rose 7.62% to $254.04 during Wednesday's session. In the last month the share price increased with 38.45%. |
| REGN | 7.52% | With a 7.52% surge, REGENERON PHARMACEUTICALS's (NASDAQ:REGN) stock price reached $604.57 during Wednesday's session, signaling positive momentum. A press release (Regeneron to Report Third Quarter 2025 Financial and Operating Results and Host Conference Call and Webcast on October 28, 2025) was released yesterday. |
Our top gainers page will show you the full list.
Losers
| Ticker | Change | Comment |
|---|---|---|
| CTVA | -9.3% | CORTEVA INC's (NYSE:CTVA) shares fell 9.3% to $61.34 during Wednesday's session. Shareholders saw the stock price going 21.22% higher is the past 6 months. |
| IT | -6.24% | Investors witnessed a 6.24% drop in GARTNER INC's (NYSE:IT) stock price, which closed at $246.47 during Wednesday's session. Shareholders saw the stock price going 34.33% lower in the past 3 months. |
| NWS | -5.27% | There was a downturn in NEWS CORP - CLASS B's (NASDAQ:NWS) shares, as they experienced a 5.27% decline, closing at $32.73 during Wednesday's session. In the last 6 months the stock gained 24.73%. |
| HUM | -4.63% | The market experienced a downward movement in HUMANA INC's (NYSE:HUM) stock price, closing at $248.13 with a 4.63% decrease during Wednesday's session. Yesterday the company had a press release: Humana’s 2026 Medicare Advantage Plans Prioritize Simplicity, Stability and Quality Care for Beneficiaries. |
| NWSA | -4.56% | Investors witnessed a 4.56% decrease in NEWS CORP - CLASS A's (NASDAQ:NWSA) stock price, which closed at $29.31 during Wednesday's session. In the last 6 months the share price increased with 24.94%. |
| DLTR | -3.99% | DOLLAR TREE INC's (NASDAQ:DLTR) shares fell 3.99% to $90.6 during Wednesday's session. Shareholders saw the stock price going 39.7% higher is the past 6 months. |
| TYL | -3.88% | TYLER TECHNOLOGIES INC's (NYSE:TYL) stock price faced a 3.88% decline, reaching $502.85 during Wednesday's session. |
| PAYC | -3.78% | During Wednesday's session, PAYCOM SOFTWARE INC's (NYSE:PAYC) shares took a tumble, falling 3.78% to $200.26. In the last year the stock gained 23.91%. |
| DGX | -3.76% | QUEST DIAGNOSTICS INC's (NYSE:DGX) stock price is declining with 3.76% to a price of $183.42. In the last year the stock gained 26.39%. |
| IPG | -3.53% | Investors witnessed a 3.53% drop in INTERPUBLIC GROUP OF COS INC's (NYSE:IPG) stock price, which closed at $26.93 during Wednesday's session. |
Our top losers page will show you the full list.
NASDAQ:BIIB (10/1/2025, 2:58:08 PM)
152.87
+12.79 (+9.13%)
NYSE:CRL (10/1/2025, 2:57:56 PM)
169.47
+13.01 (+8.32%)
NASDAQ:REGN (10/1/2025, 2:58:01 PM)
603.742
+41.47 (+7.38%)
NYSE:LLY (10/1/2025, 2:58:02 PM)
828.349
+65.35 (+8.56%)
NYSE:MRK (10/1/2025, 2:58:06 PM)
90.62
+6.69 (+7.97%)
NYSE:HUM (10/1/2025, 2:58:00 PM)
247.61
-12.56 (-4.83%)
NYSE:DGX (10/1/2025, 2:57:35 PM)
183.39
-7.19 (-3.77%)
NYSE:IPG (10/1/2025, 2:58:10 PM)
26.84
-1.07 (-3.83%)
NASDAQ:NWSA (10/1/2025, 2:58:07 PM)
29.255
-1.46 (-4.74%)
NYSE:IT (10/1/2025, 2:57:40 PM)
246.015
-16.86 (-6.41%)
NASDAQ:DLTR (10/1/2025, 2:58:03 PM)
90.515
-3.86 (-4.08%)
NASDAQ:STX (10/1/2025, 2:58:09 PM)
255.16
+19.1 (+8.09%)
NYSE:TMO (10/1/2025, 2:58:06 PM)
531.88
+46.86 (+9.66%)
NYSE:TYL (10/1/2025, 2:57:08 PM)
503.165
-19.99 (-3.82%)
NYSE:AES (10/1/2025, 2:58:09 PM)
15.305
+2.14 (+16.3%)
NASDAQ:NWS (10/1/2025, 2:58:08 PM)
32.66
-1.89 (-5.47%)
NYSE:PAYC (10/1/2025, 2:58:02 PM)
199.45
-8.69 (-4.18%)
NASDAQ:MRNA (10/1/2025, 2:58:09 PM)
27.975
+2.15 (+8.3%)
NYSE:CTVA (10/1/2025, 2:58:08 PM)
61.465
-6.16 (-9.12%)
NASDAQ:DDOG (10/1/2025, 2:58:07 PM)
153.11
+10.71 (+7.52%)
Find more stocks in the Stock Screener
BIIB Latest News and Analysis
