| Nov 17, 2025 | Norrett Kevin | Grant | 14286 | 0.00 | $ 0.00 |
| Nov 10, 2025 | Joshi Manher | Grant | 16071 | 0.00 | $ 0.00 |
| Oct 13, 2025 | Hahn Mark W | Grant | 10046 | 0.00 | $ 0.00 |
| Jul 1, 2025 | Hirano Patricia C | Open Market Sale | 3830 | 82.76 | $ 316,970.80 |
| Apr 1, 2025 | Hirano Patricia C | Open Market Sale | 3782 | 70.11 | $ 265,156.02 |
| Mar 28, 2025 | Pauls Matthew | Option Excercise | 5937 | 4.60 | $ 27,310.20 |
| Mar 28, 2025 | Pauls Matthew | Open Market Sale | 5937 | 71.55 | $ 424,797.10 |
| Mar 27, 2025 | Hirano Patricia C | Open Market Sale | 156315 | 68.51 | $ 10,709,353.03 |
| Mar 27, 2025 | Hirano Patricia C | Option Excercise | 74831 | 8.14 | $ 608,974.57 |
| Mar 27, 2025 | Anish Bhatnagar | Open Market Sale | 699095 | 67.62 | $ 47,271,960.10 |
| Mar 27, 2025 | Anish Bhatnagar | Option Excercise | 523809 | 12.17 | $ 6,373,861.16 |
| Mar 27, 2025 | Huang Michael F. | Open Market Sale | 14583 | 69.51 | $ 1,013,627.05 |
| Mar 27, 2025 | Huang Michael F. | Option Excercise | 10000 | 21.93 | $ 219,300.00 |
| Mar 27, 2025 | Yen Kristen | Open Market Sale | 95500 | 66.77 | $ 6,376,788.66 |
| Mar 27, 2025 | Yen Kristen | Option Excercise | 40638 | 4.97 | $ 201,966.30 |
| Mar 27, 2025 | Manning Meredith | Open Market Sale | 45249 | 67.28 | $ 3,044,342.88 |
| Mar 27, 2025 | Manning Meredith | Option Excercise | 37000 | 46.31 | $ 1,713,470.00 |
| Mar 27, 2025 | Mackaness James H | Open Market Sale | 90622 | 69.44 | $ 6,293,177.03 |
| Mar 27, 2025 | Mackaness James H | Option Excercise | 70000 | 11.72 | $ 820,125.00 |
| Mar 26, 2025 | Vivo Opportunity, LLC | Open Market Sale | 1833557 | 67.87 | $ 124,449,124.20 |
| Mar 26, 2025 | Vivo Opportunity Fund Holdings, L.P. | Open Market Sale | 1833557 | 67.87 | $ 124,449,124.20 |
| Jan 21, 2025 | Anish Bhatnagar | Grant | 53900 | 0.00 | $ 0.00 |
| Jan 21, 2025 | Yen Kristen | Grant | 6400 | 0.00 | $ 0.00 |
| Jan 21, 2025 | Manning Meredith | Grant | 13600 | 0.00 | $ 0.00 |
| Jan 21, 2025 | Mackaness James H | Grant | 14500 | 0.00 | $ 0.00 |
| Jan 21, 2025 | Huang Michael F. | Grant | 6400 | 0.00 | $ 0.00 |
| Jan 21, 2025 | Hirano Patricia C | Grant | 6400 | 0.00 | $ 0.00 |
| Jan 3, 2025 | Anish Bhatnagar | Open Market Sale | 10154 | 46.18 | $ 468,875.17 |
| Jan 3, 2025 | Yen Kristen | Open Market Sale | 2340 | 46.18 | $ 108,052.78 |
| Jan 3, 2025 | Mackaness James H | Open Market Sale | 3791 | 46.18 | $ 175,054.73 |
| Jan 3, 2025 | Hirano Patricia C | Open Market Sale | 1459 | 46.18 | $ 67,371.37 |