| Dec 8, 2025 | Kovacs Shane William Charles | Other Disposition | 75000 | 0.00 | $ 0.00 |
| Nov 26, 2025 | Kovacs Shane William Charles | Other Disposition | 225000 | 0.00 | $ 0.00 |
| Nov 25, 2025 | RAPPAPORT ANDREW | Other Disposition | 35868 | 0.00 | $ 0.00 |
| Nov 21, 2025 | RAPPAPORT ANDREW | Option Excercise | 35868 | 0.39 | $ 13,988.52 |
| Sep 16, 2025 | Harmon Cyrus | Open Market Sale | 25000 | 8.19 | $ 204,840.64 |
| Jan 10, 2025 | Bain Capital Life Sciences Investors, LLC | Other Disposition | 3500000 | | $ 0.00 |
| Jan 10, 2025 | Bain Capital Life Sciences IV General Partner, LLC | Other Disposition | 3500000 | | $ 0.00 |
| Jan 10, 2025 | Bain Capital Life Sciences Fund IV, L.P. | Other Disposition | 3500000 | | $ 0.00 |
| Jan 10, 2025 | Bain Capital Life Sciences Opportunities IV GP, LLC | Other Disposition | 3500000 | | $ 0.00 |
| Jan 10, 2025 | Bain Capital Life Sciences Opportunities IV, L.P. | Other Disposition | 3500000 | | $ 0.00 |
| Jan 10, 2025 | BVF PARTNERS L P/IL | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BIOTECHNOLOGY VALUE FUND L P | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BVF I GP LLC | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BIOTECHNOLOGY VALUE FUND II LP | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BVF II GP LLC | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | Biotechnology Value Trading Fund OS LP | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BVF Partners OS Ltd. | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BVF GP HOLDINGS LLC | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | BVF INC/IL | Other Disposition | 420000 | | $ 0.00 |
| Jan 10, 2025 | LAMPERT MARK N | Other Disposition | 420000 | | $ 0.00 |
| Jan 8, 2025 | Bain Capital Life Sciences Opportunities IV GP, LLC | Open Market Purchase | 300000 | 5.76 | $ 1,727,370.00 |
| Jan 8, 2025 | Bain Capital Life Sciences Opportunities IV, L.P. | Open Market Purchase | 300000 | 5.76 | $ 1,727,370.00 |
| Jan 8, 2025 | Bain Capital Life Sciences Investors, LLC | Open Market Purchase | 300000 | 5.76 | $ 1,727,370.00 |
| Jan 8, 2025 | Bain Capital Life Sciences IV General Partner, LLC | Open Market Purchase | 300000 | 5.76 | $ 1,727,370.00 |
| Jan 8, 2025 | Bain Capital Life Sciences Fund IV, L.P. | Open Market Purchase | 300000 | 5.76 | $ 1,727,370.00 |
| Dec 17, 2024 | Graham G. Walmsley | Open Market Sale | 700761 | 6.75 | $ 4,730,136.75 |
| Dec 17, 2024 | Graham G. Walmsley | Open Market Purchase | 700761 | 6.75 | $ 4,730,136.75 |
| Dec 16, 2024 | Zojwalla Naseem | Option Excercise | 14000 | 4.87 | $ 68,180.00 |
| Dec 13, 2024 | Graham G. Walmsley | Open Market Sale | 700761 | 6.75 | $ 4,730,136.75 |
| Dec 13, 2024 | Graham G. Walmsley | Open Market Purchase | 700761 | 6.75 | $ 4,730,136.75 |
| Dec 11, 2024 | Harmon Cyrus | Open Market Sale | 8137 | 8.68 | $ 70,597.09 |
| Dec 11, 2024 | Myles David C. | Open Market Sale | 13614 | 8.68 | $ 118,116.24 |
| Dec 11, 2024 | Zojwalla Naseem | Open Market Sale | 14522 | 8.68 | $ 125,994.12 |
| Dec 11, 2024 | Kovacs Shane William Charles | Open Market Sale | 18356 | 8.68 | $ 159,259.34 |
| Dec 11, 2024 | Bohen Sean | Open Market Sale | 57174 | 8.68 | $ 496,051.75 |