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Day One Biopharmaceuticals Inc (NASDAQ:DAWN) Reports Q2 2025 Earnings: Revenue Growth but Wider-Than-Expected Loss

By Mill Chart

Last update: Aug 5, 2025

Day One Biopharmaceuticals Inc (NASDAQ:DAWN) Reports Q2 2025 Earnings: Revenue Growth but Wider-Than-Expected Loss

Day One Biopharmaceuticals Inc released its second-quarter 2025 financial results, revealing a mixed performance relative to analyst expectations. While revenue growth for its flagship drug OJEMDA™ (tovorafenib) showed steady progress, the company’s earnings per share (EPS) fell short of estimates, contributing to a sharp after-hours decline in its stock price.

Key Financial Highlights

  • Revenue: The company reported Q2 revenue of $33.91 million, slightly below the consensus estimate of $36.01 million. Despite the miss, this represents a 10% quarter-over-quarter increase in OJEMDA sales, signaling continued commercial traction.
  • Earnings Per Share (EPS): Day One posted an EPS of -$0.29, better than the estimated -$0.364, but still reflecting ongoing losses as the company invests in commercialization and pipeline development.
  • Full-Year Guidance: Management reaffirmed its 2025 net product revenue forecast for OJEMDA at $140–150 million, which aligns closely with analyst sales estimates of $152.7 million for the year.

Market Reaction

Following the earnings release, DAWN shares dropped nearly 11.8% in after-hours trading. The decline appears driven by investor concerns over:

  • Revenue Miss: While OJEMDA sales grew sequentially, the slight shortfall against expectations may have disappointed some investors anticipating stronger adoption.
  • Profitability Challenges: Despite beating EPS estimates, the company remains unprofitable, and the market may be reacting to the broader uncertainty around when Day One will achieve sustained positive cash flow.
  • Pipeline Execution Risks: While not directly tied to this earnings report, biotech investors often weigh clinical and commercial execution risks heavily, which could be contributing to the negative sentiment.

Corporate and Pipeline Updates

The earnings release also highlighted progress in Day One’s broader strategy:

  • OJEMDA Commercialization: The drug continues to gain traction in treating pediatric low-grade glioma, with management emphasizing its differentiated profile as a brain-penetrant RAF kinase inhibitor.
  • Pipeline Development: The company is advancing DAY301, a PTK7-targeted antibody-drug conjugate (ADC), and its VRK1 program, focused on DNA damage repair—both of which remain in earlier-stage development.

Looking Ahead

Analysts expect Q3 2025 revenue of $40.91 million, with an estimated EPS of -$0.34. The full-year revenue outlook from management appears achievable, but investors will be watching for:

  • Acceleration in OJEMDA sales to meet or exceed the high end of guidance.
  • Progress in pipeline candidates, particularly DAY301, which could provide additional catalysts if clinical data is positive.
  • Cost management as the company balances commercialization expenses with R&D investments.

For a deeper dive into Day One’s earnings and analyst estimates, visit the earnings and estimates page.

Disclaimer: This article is for informational purposes only and does not constitute investment advice. Investors should conduct their own research or consult a financial advisor before making any decisions.

DAY ONE BIOPHARMACEUTICALS I

NASDAQ:DAWN (8/5/2025, 4:38:19 PM)

After market: 6.06 -0.82 (-11.92%)

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+0.14 (+2.15%)



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