Bristol Myers Squibb Co (NYSE:BMY) Beats Q4 2025 Earnings Estimates and Provides Strong 2026 Outlook

Last update: Feb 5, 2026

Bristol Myers Squibb Co (NYSE:BMY) has reported its fourth-quarter and full-year 2025 financial results, delivering a performance that exceeded analyst expectations on key profitability metrics. The pharmaceutical giant's report, coupled with a forward-looking outlook that surpasses current Wall Street forecasts, appears to be resonating positively with investors in early trading.

Earnings and Revenue Performance

For the critical fourth quarter of 2025, Bristol Myers Squibb posted results that edged past consensus estimates. The company's ability to beat on the bottom line is a focal point for analysts tracking its progress in managing a transitional period for its product portfolio.

  • Non-GAAP Earnings Per Share (EPS): Reported at $1.26, surpassing the analyst estimate of $1.13.
  • Revenue: Reported at $12.50 billion, coming in slightly above the estimated $12.40 billion.

This quarterly beat demonstrates effective cost management and operational execution, particularly as the company navigates the loss of exclusivity for some of its established blockbuster drugs. The top-line revenue, while only a modest beat, indicates that sales are holding steady against expectations.

Market Reaction and Price Action

The immediate market reaction to the earnings release and accompanying outlook has been decisively positive. In pre-market trading, the stock is indicating an opening gain of approximately 1.5%. This positive momentum builds on a steady upward trend for the shares over recent weeks, with the stock having gained roughly 5.8% over the past month. The pre-market move suggests investors are rewarding the company for its better-than-expected profitability and its confident guidance for the year ahead.

Forward-Looking Guidance

A significant driver of the positive investor sentiment appears to be the company's financial outlook for 2026. According to recent news reports, Bristol Myers provided sales and profit forecasts that topped Wall Street's expectations. This guidance is seen as a strong signal that the company's newer medicines in oncology, immunology, and cardiology are gaining sufficient commercial traction to offset declines in its mature product portfolio.

While the specific numerical guidance from management is detailed in the company's investor presentation, the provided analyst consensus estimates for the coming periods offer a benchmark:

  • Full-Year 2026 Revenue Estimate: $44.52 billion
  • Full-Year 2026 EPS Estimate: $6.07
  • Q1 2026 Revenue Estimate: $10.63 billion
  • Q1 2026 EPS Estimate: $1.43

The company's own forecast, reported as being above these figures, underscores management's confidence in the growth trajectory of newer drugs like Camzyos, Sotyktu, and Reblozyl, among others.

Press Release Summary

The official press release announced the availability of the company's detailed fourth-quarter and full-year 2025 financial results. It served as a notice for the earnings conference call, directing investors and analysts to the company's Investor Relations website to access the complete earnings press release and accompanying presentation materials. The release reaffirmed the company's mission of developing innovative medicines for serious diseases across key therapeutic areas including oncology, hematology, and immunology.

For a detailed breakdown of historical earnings, future estimates, and analyst projections, readers can review the comprehensive data available on the BMY earnings and estimates page.

Disclaimer: This article is for informational purposes only and does not constitute financial advice, a recommendation, or an endorsement of any security or investment strategy. Investors should conduct their own research and consult with a qualified financial advisor before making any investment decisions.