These stocks that are showing activity before the opening bell on Wednesday.

Last update: Oct 8, 2025

The US market session of Wednesday has yet to be opened, let's have a look at the top gainers and losers in the pre-market session today.

Today's pre-market gainers

Ticker	Change	Comment
UPC	148.0%	UNIVERSE PHARMACEUTICALS INC's (NASDAQ:UPC) shares rose 148.0% to $12.84. Shareholders saw the stock price going 29.25% higher in the past month.
ACXP	92.07%	ACURX PHARMACEUTICALS INC (NASDAQ:ACXP) experienced an impressive 92.07% increase in share price, reaching $8.24 during the pre-market session on Wednesday. In the last 3 months the share price dropped with 54.65%.
XTLB	60.71%	XTL BIOPHARMACEUTICALS-ADR (NASDAQ:XTLB) recorded a 60.71% increase in share price during the pre-market session, reaching $2.25 on Wednesday. The upward trend from yesterday's 22.81% gain continues in today's pre-market session, reflecting sustained positive performance for XTLB.
YYAI	59.83%	During Wednesday's pre-market trading, CONNEXA SPORTS TECHNOLOGIES (NASDAQ:YYAI) demonstrated strong momentum, with the stock price rising 59.83% to $0.29. YYAI seems to be recovering from a -92.83% loss in the previous session.
PCSA	55.56%	PROCESSA PHARMACEUTICALS INC (NASDAQ:PCSA) rose 55.56% to $0.56 during Wednesday's pre-market session. The positive trend witnessed yesterday with a 29.03% gain persists in today's pre-market, indicating sustained growth for PCSA.
BURU	45.45%	NUBURU INC (NYSEARCA:BURU) recorded a 45.45% increase in share price during the pre-market session, reaching $0.69 on Wednesday. Today's pre-market session shows a continuation of the previous session's success for BURU, with a 45.45% increase following yesterday's 86.27% gain. A press release (NUBURU to Acquire Orbit, Expanding Defense & Security Hub with Cutting-Edge Operational Resilience Solutions) was released yesterday.
SCWO	39.63%	The pre-market session on Wednesday saw a significant rise in 374WATER INC's (NASDAQ:SCWO) shares, climbing 39.63% to $0.51. The positive momentum from yesterday's 10.64% gain carries forward into today's pre-market session, with an additional 39.63% increase.
BIAF	33.88%	BIOAFFINITY TECHNOLOGIES INC's (NASDAQ:BIAF) shares rose 33.88% to $3.28 during Wednesday's pre-market session. The stock is trading 67.07% lower than a month ago.
TRX	31.84%	During Wednesday's pre-market trading, TRX GOLD CORP (NYSEARCA:TRX) demonstrated strong momentum, with the stock price rising 31.84% to $0.82. A press release (TRX Gold Announces Preliminary Q4 2025 Results) was released earlier today.
CRMLW	29.88%	CRITICAL METALS CORP-28's (NASDAQ:CRMLW) stock price increased by 29.88% to $4.39. After yesterday's drop of -26.79%, it looks like it is bouncing back in today's pre-market session.

Our premarket gainers page will show you the full list.

Today's pre-market losers

Ticker	Change	Comment
COCH	-37.42%	ENVOY MEDICAL INC's (NASDAQ:COCH) shares experienced a 37.42% decline, falling to $0.99 during Wednesday's pre-market session. After a strong performance yesterday with a 97.07% gain, COCH shows signs of retracement with a 37.42% decline in today's pre-market session.
GLTO	-34.82%	During Wednesday's pre-market session, the shares of GALECTO INC (NASDAQ:GLTO) declined by 34.82%, reaching $11.68. Following an impressive 383.0% run-up in yesterday's session, GLTO experiences a pullback in today's pre-market session, showcasing the market's dynamic nature.
CISS	-30.71%	The pre-market session on Wednesday witnessed a 30.71% decrease in C3IS INC's (NASDAQ:CISS) shares, with the stock price falling to $2.82. Yesterday's 84.16% gain in CISS gives way to a 30.71% decrease in today's pre-market session, showcasing market fluctuations.
KPTI	-23.22%	KARYOPHARM THERAPEUTICS INC's (NASDAQ:KPTI) stock price recorded a 23.22% decrease, falling to $4.43. In the last 3 months the stock gained 26.81%.
PENG	-20.59%	During Wednesday's pre-market session, the shares of PENGUIN SOLUTIONS INC (NASDAQ:PENG) declined by 20.59%, reaching $21.44. A press release (Penguin Solutions Reports Q4 and Full Year Fiscal 2025 Financial Results) was released yesterday.
ESPR	-19.74%	The pre-market session on Wednesday witnessed a 19.74% decrease in ESPERION THERAPEUTICS INC's (NASDAQ:ESPR) shares, with the stock price falling to $2.48. A press release (Esperion Announces Pricing of Public Offering of Common Stock) was released yesterday.
JOB.W	-19.27%	The stock price of JOBY AVIATION INC -CW25 (NYSE:JOB.W) is experiencing a decline of 19.27%, reaching $6.45 in today's pre-market session on Wednesday. In the last month the share price increased with 92.53%.
STSSW	-19.2%	SHARPS TECHNOLOGY INC -27's (NASDAQ:STSSW) stock price decreased by 19.2% to $0.04. In the last 3 months the stock gained 122.0%.
BJDX	-16.82%	Despite yesterday's decline, BLUEJAY DIAGNOSTICS INC (NASDAQ:BJDX) experienced a further 16.82% decrease in share price during Wednesday's pre-market session, reaching $1.78. The current market conditions exhibit high volatility as BJDX retraces its steps after yesterday's 38.06% gain.
TDIC	-15.54%	The stock price of DREAMLAND LTD-A (NASDAQ:TDIC) is experiencing a decline of 15.54%, reaching $6.14 in today's pre-market session on Wednesday. The stock is trading 93.29% higher than a month ago.

For the full premarket loser list go to our premarket losers page.