These stocks that are showing activity before the opening bell on Wednesday.

Last update: Oct 8, 2025

The US market session of Wednesday has yet to be opened, let's have a look at the top gainers and losers in the pre-market session today.


premarket

Today's pre-market gainers

TickerChangeComment
UPC148.0%UNIVERSE PHARMACEUTICALS INC's (NASDAQ:UPC) shares rose 148.0% to $12.84. Shareholders saw the stock price going 29.25% higher in the past month.
ACXP92.07%ACURX PHARMACEUTICALS INC (NASDAQ:ACXP) experienced an impressive 92.07% increase in share price, reaching $8.24 during the pre-market session on Wednesday. In the last 3 months the share price dropped with 54.65%.
XTLB60.71%XTL BIOPHARMACEUTICALS-ADR (NASDAQ:XTLB) recorded a 60.71% increase in share price during the pre-market session, reaching $2.25 on Wednesday. The upward trend from yesterday's 22.81% gain continues in today's pre-market session, reflecting sustained positive performance for XTLB.
YYAI59.83%During Wednesday's pre-market trading, CONNEXA SPORTS TECHNOLOGIES (NASDAQ:YYAI) demonstrated strong momentum, with the stock price rising 59.83% to $0.29. YYAI seems to be recovering from a -92.83% loss in the previous session.
PCSA55.56%PROCESSA PHARMACEUTICALS INC (NASDAQ:PCSA) rose 55.56% to $0.56 during Wednesday's pre-market session. The positive trend witnessed yesterday with a 29.03% gain persists in today's pre-market, indicating sustained growth for PCSA.
BURU45.45%NUBURU INC (NYSEARCA:BURU) recorded a 45.45% increase in share price during the pre-market session, reaching $0.69 on Wednesday. Today's pre-market session shows a continuation of the previous session's success for BURU, with a 45.45% increase following yesterday's 86.27% gain. A press release (NUBURU to Acquire Orbit, Expanding Defense & Security Hub with Cutting-Edge Operational Resilience Solutions) was released yesterday.
SCWO39.63%The pre-market session on Wednesday saw a significant rise in 374WATER INC's (NASDAQ:SCWO) shares, climbing 39.63% to $0.51. The positive momentum from yesterday's 10.64% gain carries forward into today's pre-market session, with an additional 39.63% increase.
BIAF33.88%BIOAFFINITY TECHNOLOGIES INC's (NASDAQ:BIAF) shares rose 33.88% to $3.28 during Wednesday's pre-market session. The stock is trading 67.07% lower than a month ago.
TRX31.84%During Wednesday's pre-market trading, TRX GOLD CORP (NYSEARCA:TRX) demonstrated strong momentum, with the stock price rising 31.84% to $0.82. A press release (TRX Gold Announces Preliminary Q4 2025 Results) was released earlier today.
CRMLW29.88%CRITICAL METALS CORP-28's (NASDAQ:CRMLW) stock price increased by 29.88% to $4.39. After yesterday's drop of -26.79%, it looks like it is bouncing back in today's pre-market session.

Our premarket gainers page will show you the full list.

Today's pre-market losers

TickerChangeComment
COCH-37.42%ENVOY MEDICAL INC's (NASDAQ:COCH) shares experienced a 37.42% decline, falling to $0.99 during Wednesday's pre-market session. After a strong performance yesterday with a 97.07% gain, COCH shows signs of retracement with a 37.42% decline in today's pre-market session.
GLTO-34.82%During Wednesday's pre-market session, the shares of GALECTO INC (NASDAQ:GLTO) declined by 34.82%, reaching $11.68. Following an impressive 383.0% run-up in yesterday's session, GLTO experiences a pullback in today's pre-market session, showcasing the market's dynamic nature.
CISS-30.71%The pre-market session on Wednesday witnessed a 30.71% decrease in C3IS INC's (NASDAQ:CISS) shares, with the stock price falling to $2.82. Yesterday's 84.16% gain in CISS gives way to a 30.71% decrease in today's pre-market session, showcasing market fluctuations.
KPTI-23.22%KARYOPHARM THERAPEUTICS INC's (NASDAQ:KPTI) stock price recorded a 23.22% decrease, falling to $4.43. In the last 3 months the stock gained 26.81%.
PENG-20.59%During Wednesday's pre-market session, the shares of PENGUIN SOLUTIONS INC (NASDAQ:PENG) declined by 20.59%, reaching $21.44. A press release (Penguin Solutions Reports Q4 and Full Year Fiscal 2025 Financial Results) was released yesterday.
ESPR-19.74%The pre-market session on Wednesday witnessed a 19.74% decrease in ESPERION THERAPEUTICS INC's (NASDAQ:ESPR) shares, with the stock price falling to $2.48. A press release (Esperion Announces Pricing of Public Offering of Common Stock) was released yesterday.
JOB.W-19.27%The stock price of JOBY AVIATION INC -CW25 (NYSE:JOB.W) is experiencing a decline of 19.27%, reaching $6.45 in today's pre-market session on Wednesday. In the last month the share price increased with 92.53%.
STSSW-19.2%SHARPS TECHNOLOGY INC -27's (NASDAQ:STSSW) stock price decreased by 19.2% to $0.04. In the last 3 months the stock gained 122.0%.
BJDX-16.82%Despite yesterday's decline, BLUEJAY DIAGNOSTICS INC (NASDAQ:BJDX) experienced a further 16.82% decrease in share price during Wednesday's pre-market session, reaching $1.78. The current market conditions exhibit high volatility as BJDX retraces its steps after yesterday's 38.06% gain.
TDIC-15.54%The stock price of DREAMLAND LTD-A (NASDAQ:TDIC) is experiencing a decline of 15.54%, reaching $6.14 in today's pre-market session on Wednesday. The stock is trading 93.29% higher than a month ago.

For the full premarket loser list go to our premarket losers page.

TRX GOLD CORP

NYSEARCA:TRX (2/3/2026, 8:04:00 PM)

Premarket: 1.75 +0.05 (+2.94%)

1.7

+0.06 (+3.66%)


ESPERION THERAPEUTICS INC

NASDAQ:ESPR (2/3/2026, 8:13:04 PM)

Premarket: 3.58 +0.07 (+1.99%)

3.51

+0.01 (+0.29%)


XTL BIOPHARMACEUTICALS-ADR

NASDAQ:XTLB (2/3/2026, 8:00:03 PM)

0.8365

+0 (+0.06%)


KARYOPHARM THERAPEUTICS INC

NASDAQ:KPTI (2/3/2026, 8:28:24 PM)

After market: 6.68 +0.13 (+1.98%)

6.55

+0.24 (+3.8%)


PROCESSA PHARMACEUTICALS INC

NASDAQ:PCSA (2/3/2026, 8:00:00 PM)

After market: 2.33 -0.11 (-4.51%)

2.44

-0.19 (-7.05%)


GALECTO INC

NASDAQ:GLTO (2/3/2026, 8:21:03 PM)

25.61

-1.75 (-6.4%)


UNIVERSE PHARMACEUTICALS INC

NASDAQ:UPC (2/3/2026, 8:00:02 PM)

After market: 4.4532 -0.08 (-1.7%)

4.53

+0.12 (+2.72%)


ACURX PHARMACEUTICALS INC

NASDAQ:ACXP (2/3/2026, 8:00:00 PM)

After market: 2.31 +0.03 (+1.32%)

2.28

-0.1 (-4.2%)


JOBY AVIATION INC -CW25

NYSE:JOB.W (2/3/2026, 8:27:45 PM)

2.56

+0.1 (+4.07%)


BLUEJAY DIAGNOSTICS INC

NASDAQ:BJDX (2/3/2026, 8:01:47 PM)

Premarket: 3.19 0 (0%)

3.19

-0.19 (-5.62%)


SHARPS TECHNOLOGY INC -27

NASDAQ:STSSW (2/3/2026, 8:00:00 PM)

After market: 0.0289 +0 (+12.89%)

0.0256

0 (-14.38%)


374WATER INC

NASDAQ:SCWO (2/3/2026, 8:00:02 PM)

3

-0.2 (-6.25%)


BIOAFFINITY TECHNOLOGIES INC

NASDAQ:BIAF (2/3/2026, 8:01:37 PM)

Premarket: 1.07 0 (0%)

1.07

-0.2 (-15.75%)


NUBURU INC

NYSEARCA:BURU (2/3/2026, 8:04:00 PM)

Premarket: 0.173 0 (-1.42%)

0.1755

-0.01 (-4.05%)


C3IS INC

NASDAQ:CISS (2/3/2026, 8:06:26 PM)

Premarket: 1.55 -0.11 (-6.63%)

1.66

-0.29 (-14.87%)


ENVOY MEDICAL INC

NASDAQ:COCH (2/3/2026, 8:08:15 PM)

After market: 0.5999 +0.01 (+0.96%)

0.5942

-0.06 (-8.57%)


CRITICAL METALS CORP-28

NASDAQ:CRMLW (2/3/2026, 8:08:39 PM)

After market: 7.59 +0.16 (+2.08%)

7.435

+1.63 (+28.19%)


AIRWA INC

NASDAQ:YYAI (2/3/2026, 8:00:03 PM)

Premarket: 1.16 +0.04 (+3.57%)

1.12

-0.06 (-5.08%)


PENGUIN SOLUTIONS INC

NASDAQ:PENG (2/3/2026, 8:00:00 PM)

Premarket: 18.24 +0.03 (+0.16%)

18.21

-1.59 (-8.03%)


DREAMLAND LTD-A

NASDAQ:TDIC (2/3/2026, 8:00:02 PM)

Premarket: 0.189 0 (0%)

0.189

0 (-0.32%)



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