Let's have a look at what is happening on the US markets before the opening bell on Friday. Below you can find the top gainers and losers in today's pre-market session.

Gainers
| Ticker | Change | Comment |
|---|---|---|
| CUE | 87.45% | The pre-market session on Friday saw a significant rise in CUE BIOPHARMA INC's (NASDAQ:CUE) shares, climbing 87.45% to $27.63. This is a continuation of yesterday's gain of 13.38%. Yesterday the company had a press release: Cue Biopharma Announces $30 Million Private Placement. |
| ESPR | 57.5% | ESPERION THERAPEUTICS INC's (NASDAQ:ESPR) stock price increased by 57.5% to $3.15. A press release (Esperion to be Acquired by ARCHIMED) was released earlier today. |
| SOBR | 42.05% | SOBR SAFE INC's (NASDAQ:SOBR) stock price is advancing with 42.05% to a price of $0.78. A press release (SOBRsafe Proposes Business Combination with Clean World Ventures, Inc.) was released yesterday. |
| AKAN | 28.68% | During Friday's pre-market trading, AKANDA CORP (NASDAQ:AKAN) demonstrated strong momentum, with the stock price rising 28.68% to $63.0. Yesterday's 88.38% gain sets the stage for a strong start in today's pre-market session, as AKAN shows a 28.68% increase. |
| TWLO | 20.76% | Pre-market trading on Friday showed positive momentum for TWILIO INC - A (NYSE:TWLO), as the stock price advanced 20.76% to reach $178.8. Yesterday the company had a press release: Twilio Announces First Quarter 2026 Results. |
| TEAM | 19.42% | ATLASSIAN CORP-CL A's (NASDAQ:TEAM) shares rose 19.42% to $81.91 during Friday's pre-market session. A press release (Atlassian Announces Third Quarter Fiscal Year 2026 Results) was released yesterday. |
| XRXDW | 18.6% | During Friday's pre-market session, XEROX HOLDINGS CORP (NASDAQ:XRXDW) exhibited strong growth, with the stock price climbing 18.6% to $0.22. Continuing its strong performance from the previous session, XRXDW experienced a significant 61.05% gain, setting a positive tone for today's pre-market session. |
| CERS | 18.23% | CERUS CORP (NASDAQ:CERS) rose 18.23% to $2.4 during Friday's pre-market session. A press release (Cerus Corporation Announces First Quarter 2026 Financial Results) was released yesterday. |
| FIVN | 17.73% | FIVE9 INC's (NASDAQ:FIVN) stock price increased by 17.73% to $20.25. A press release (Five9 Announces First Quarter 2026 Financial Results) was released yesterday. |
| ISPC | 17.4% | During Friday's pre-market session, ISPECIMEN INC (NASDAQ:ISPC) experienced a 17.4% increase, with the stock price reaching $6.14. The upward trend from yesterday's 22.48% gain continues in today's pre-market session, reflecting sustained positive performance for ISPC. |
For the full premarket gainers list go to our premarket gainers page.
Pre-market losers
| Ticker | Change | Comment |
|---|---|---|
| AKTX | -25.93% | Today's pre-market session reveals a 25.93% decline in the stock price of AKARI THERAPEUTICS PLC-ADR (NASDAQ:AKTX), now priced at $4.0. Shareholders saw the stock price going 42.45% lower in the past 3 months. |
| RBLX | -23.81% | Today's pre-market session reveals a 23.81% decline in the stock price of ROBLOX CORP -CLASS A (NYSE:RBLX), now priced at $42.1. A press release (Roblox Reports First Quarter 2026 Financial Results) was released yesterday. |
| SENS | -22.25% | The pre-market session on Friday witnessed a 22.25% decrease in SENSEONICS HOLDINGS INC's (NASDAQ:SENS) shares, with the stock price falling to $5.14. A press release (Senseonics Announces Pricing of $80 Million Public Offering of Common Stock and Pre-Funded Warrants) was released yesterday. |
| RNTX | -21.03% | The stock price of REIN THERAPEUTICS INC (NASDAQ:RNTX) is experiencing a decline of 21.03%, reaching $1.07 in today's pre-market session on Friday. In the last year the stock lost 25.55%. |
| SKBL | -19.78% | Investors observed a 19.78% decline in SKYLINE BUILDERS GROUP HOL-A's (NASDAQ:SKBL) stock price, which now stands at $3.65 during Friday's pre-market session. Following yesterday's notable 12.62% increase, SKBL undergoes a 19.78% decrease in today's pre-market session, suggesting a temporary pullback. Yesterday the company had a press release: Skyline Builders Group Holding Ltd and Cove Kaz Capital Group LLC Announce Merger Agreement. |
| SMMT | -19.29% | Today's pre-market session reveals a 19.29% decline in the stock price of SUMMIT THERAPEUTICS INC (NASDAQ:SMMT), now priced at $17.32. A press release (Summit Therapeutics Reports Financial Results and Operational Progress for the First Quarter Ended March 31, 2026) was released yesterday. |
| AIXI | -16.29% | XIAO I CORP's (NASDAQ:AIXI) shares experienced a 16.29% decline, falling to $0.82 during Friday's pre-market session. The stock is trading 892.0% higher than a month ago. |
| BIYA | -15.66% | Despite yesterday's decline, BAIYA INTERNATIONAL GROUP IN (NASDAQ:BIYA) experienced a further 15.66% decrease in share price during Friday's pre-market session, reaching $1.67. In the last month the stock gained 39.44%. |
| INHD | -15.51% | The stock price of INNO HOLDINGS INC (NASDAQ:INHD) is declining by 15.51%, reaching $0.07 during Friday's pre-market session. Following yesterday's challenging day, INHD closed -28.0% lower during the regular session, and the negative sentiment carries over into today's pre-market session. |
| ABTS | -14.95% | The stock price of ABITS GROUP INC (NASDAQ:ABTS) is declining by 14.95%, reaching $1.12 during Friday's pre-market session. Prices are quite volatile now: this is a reversal from yesterday's 18.92% gain. |
For the full premarket loser list go to our premarket losers page.