Which S&P500 stocks are moving on Wednesday?

Last update: Oct 1, 2025

Curious about the top performers within the S&P500 index in the middle of the day on Wednesday? Dive into the list of today's session's top gainers and losers for a comprehensive overview.

Gainers

Ticker	Change	Comment
AES	15.16%	AES CORP's (NYSE:AES) stock price displayed strong growth, advancing 15.16% and reaching $15.15 during Wednesday's session. The stock is trading 22.08% higher than 6 months ago.
REGN	8.48%	REGENERON PHARMACEUTICALS's (NASDAQ:REGN) stock price is advancing with 8.48% to a price of $609.95. Yesterday the company had a press release: Regeneron to Report Third Quarter 2025 Financial and Operating Results and Host Conference Call and Webcast on October 28, 2025.
BIIB	8.03%	Positive market sentiment drove BIOGEN INC's (NASDAQ:BIIB) stock price up by 8.03% to $151.34 during Wednesday's session. Shareholders saw the stock price going 24.56% lower is the past year.
MRNA	7.78%	MODERNA INC's (NASDAQ:MRNA) shares soared 7.78% to $27.84 during Wednesday's session. The stock is trading 57.09% lower than a year ago.
TMO	7.51%	Positive market sentiment drove THERMO FISHER SCIENTIFIC INC's (NYSE:TMO) stock price up by 7.51% to $521.44 during Wednesday's session. Yesterday the company had a press release: Thermo Fisher Scientific Prices Offering of USD-Denominated Senior Notes.
MU	7.33%	MICRON TECHNOLOGY INC (NASDAQ:MU) experienced a significant 7.33% increase, reaching $179.59 during Wednesday's session. In the last month the share price increased with 41.22%.
LLY	6.83%	Exciting news for ELI LILLY & CO (NYSE:LLY) as its stock price surged 6.83% to $815.11 during Wednesday's session.
CRL	6.72%	Positive market sentiment drove CHARLES RIVER LABORATORIES's (NYSE:CRL) stock price up by 6.72% to $166.97 during Wednesday's session.
LW	6.18%	With a 6.18% surge, LAMB WESTON HOLDINGS INC's (NYSE:LW) stock price reached $61.67 during Wednesday's session, signaling positive momentum. A press release (Lamb Weston Reports First Quarter Fiscal 2026 Results; Reaffirms Fiscal Year 2026 Outlook) was released yesterday.
AMGN	6.07%	Exciting news for AMGEN INC (NASDAQ:AMGN) as its stock price surged 6.07% to $299.34 during Wednesday's session.

To see the full list of top gainers you can use our top gainers page.

Losers

Ticker	Change	Comment
CTVA	-7.93%	Investors witnessed a 7.93% drop in CORTEVA INC's (NYSE:CTVA) stock price, which closed at $62.27 during Wednesday's session. Shareholders saw the stock price going 21.22% higher is the past 6 months.
IDXX	-5.75%	The market experienced a downward movement in IDEXX LABORATORIES INC's (NASDAQ:IDXX) stock price, closing at $602.13 with a 5.75% decrease during Wednesday's session. In the last 6 months the stock gained 62.27%.
NWS	-5.56%	NEWS CORP - CLASS B's (NASDAQ:NWS) stock price decreased by 5.56% to $32.63. The stock is trading 24.73% higher than 6 months ago.
DXCM	-4.95%	Investors witnessed a 4.95% drop in DEXCOM INC's (NASDAQ:DXCM) stock price, which closed at $63.96 during Wednesday's session.
NWSA	-4.74%	There was a downturn in NEWS CORP - CLASS A's (NASDAQ:NWSA) shares, as they experienced a 4.74% decline, closing at $29.25 during Wednesday's session. The stock is trading 24.94% higher than 6 months ago.
IPG	-4.69%	INTERPUBLIC GROUP OF COS INC's (NYSE:IPG) stock price encountered a 4.69% decline, reaching $26.6 during Wednesday's session.
OMC	-4.49%	There was a notable decline in OMNICOM GROUP's (NYSE:OMC) shares, as they dropped 4.49% to $77.87 during Wednesday's session.
IT	-4.18%	GARTNER INC's (NYSE:IT) shares fell 4.18% to $251.88 during Wednesday's session. The stock is trading 34.33% lower than 3 months ago.
SYK	-4.07%	STRYKER CORP's (NYSE:SYK) stock price encountered a 4.07% decline, reaching $354.64 during Wednesday's session. Earlier today the company had a press release: Stryker to announce financial results for its third quarter of fiscal year 2025.
DG	-4.03%	DOLLAR GENERAL CORP's (NYSE:DG) stock price encountered a 4.03% decline, reaching $99.19 during Wednesday's session. In the last year the share price increased with 22.53%.

To see the full list of top losers you can use our top losers page.