| Oct 9, 2025 | Wood David S. | Other Disposition | 33343 | | $ 0.00 |
| Oct 9, 2025 | BERGER FRANKLIN M | Other Disposition | 784404 | | $ 0.00 |
| Oct 9, 2025 | Glickman Richard M | Other Disposition | 43240 | | $ 0.00 |
| Oct 9, 2025 | Requadt Scott | Other Disposition | 30002 | | $ 0.00 |
| Oct 9, 2025 | Thorell Marella | Other Disposition | 2881 | | $ 0.00 |
| Oct 9, 2025 | Martin John Alexander | Other Disposition | 14299 | | $ 0.00 |
| Oct 9, 2025 | BVF PARTNERS L P/IL | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BIOTECHNOLOGY VALUE FUND L P | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BVF I GP LLC | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BIOTECHNOLOGY VALUE FUND II LP | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BVF II GP LLC | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | Biotechnology Value Trading Fund OS LP | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BVF Partners OS Ltd. | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BVF GP HOLDINGS LLC | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | BVF INC/IL | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | LAMPERT MARK N | Other Disposition | 11481685 | | $ 0.00 |
| Oct 9, 2025 | Parkinson David Ross | Other Disposition | 65675 | | $ 0.00 |
| Aug 5, 2025 | BVF PARTNERS L P/IL | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BIOTECHNOLOGY VALUE FUND L P | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF I GP LLC | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BIOTECHNOLOGY VALUE FUND II LP | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF II GP LLC | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | Biotechnology Value Trading Fund OS LP | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF Partners OS Ltd. | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF GP HOLDINGS LLC | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF INC/IL | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | LAMPERT MARK N | Other Aquisition | 2920000 | 0.00 | $ 292.00 |
| Aug 5, 2025 | BVF PARTNERS L P/IL | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BIOTECHNOLOGY VALUE FUND L P | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BVF I GP LLC | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BIOTECHNOLOGY VALUE FUND II LP | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BVF II GP LLC | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | Biotechnology Value Trading Fund OS LP | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BVF Partners OS Ltd. | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BVF GP HOLDINGS LLC | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | BVF INC/IL | Open Market Sale | 156 | 1.88 | $ 292.95 |
| Aug 5, 2025 | LAMPERT MARK N | Open Market Sale | 156 | 1.88 | $ 292.95 |