Get insights into the top gainers and losers of Wednesday's pre-market session.

Last update: Dec 31, 2025

The US market is yet to commence its session on Wednesday, but let's get a preview of the pre-market session and explore the top gainers and losers driving the early market movements.

Gainers

Ticker	Change	Comment
AFJK	51.37%	AIMEI HEALTH TECHNOLOGY CO's (NASDAQ:AFJK) stock price is advancing with 51.37% to a price of $125.0. Also in the previous session AFJK had a very good day: shares closed with a 89.19% gain.
NCL	50.46%	Exciting news for NORTHANN CORP (NYSEARCA:NCL) as their shares soared 50.46% to $0.29 during the pre-market session on Wednesday. Yesterday's NCL closing with a -15.28% loss highlights the price volatility, which continues to be evident in today's pre-market session.
DRCT	41.79%	Exciting news for DIRECT DIGITAL HOLDINGS IN-A (NASDAQ:DRCT) as their shares soared 41.79% to $0.09 during the pre-market session on Wednesday. After recording a 11.67% gain in the previous session, DRCT maintains its positive trajectory in today's pre-market, with an additional 41.79% increase.
MNTSW	38.41%	During Wednesday's pre-market session, MOMENTUS INC-CW26 (NASDAQ:MNTSW) experienced a 38.41% increase, with the stock price reaching $0.02. Yesterday's MNTSW closing with a -20.77% loss highlights the price volatility, which continues to be evident in today's pre-market session.
ORIS	34.43%	ORIENTAL RISE HOLDINGS LTD (NASDAQ:ORIS) experienced an impressive 34.43% increase in share price, reaching $1.64 during the pre-market session on Wednesday. Yesterday the company had a press release: Oriental Rise Holding Limited Signs Non-Binding Letter of Intent to Acquire Hubei Daguan Tea Industry Group.
ISPC	28.5%	Exciting news for ISPECIMEN INC (NASDAQ:ISPC) as their shares soared 28.5% to $0.38 during the pre-market session on Wednesday. Following a -13.15% loss in the previous session, ISPC displays significant price volatility in today's pre-market session. Yesterday the company had a press release: iSpecimen Inc. Announces Pricing of ~$5.5 Million Private Placement.
NITO	21.15%	During Wednesday's pre-market session, N2OFF INC (NASDAQ:NITO) experienced a 21.15% increase, with the stock price reaching $1.89. The decline of -12.85% in NITO observed yesterday has sparked a potential bounce-back, as evidenced in today's pre-market session.
IVP	20.8%	During Wednesday's pre-market trading, INSPIRE VETERINARY PARTNE-A (NASDAQ:IVP) demonstrated strong momentum, with the stock price rising 20.8% to $0.06. Yesterday's gain of 18.48% continues in today's pre-market with 20.8%.
VNDA	19.91%	During Wednesday's pre-market session, VANDA PHARMACEUTICALS INC (NASDAQ:VNDA) exhibited strong growth, with the stock price climbing 19.91% to $8.43. In the last month the stock gained 40.04%.
RYDE	19.72%	RYDE GROUP LTD-A's (NYSEARCA:RYDE) stock price is advancing with 19.72% to a price of $0.31. The stock is trading 49.13% lower than a month ago.

To see the full list of premarket gainers you can use our premarket gainers page.

Pre-market losers

Ticker	Change	Comment
SMX	-16.4%	SMX SECURITY MATTERS PLC's (NASDAQ:SMX) shares fell 16.4% to $43.01 during Wednesday's pre-market session. SMX already had a hard day yesterday: closing -39.43% lower during the regular session. A press release (SMX: Why Luxury, From Denim to Couture, Can't Afford "Trust Me" Anymore) was released yesterday.
MLEC	-16.26%	The stock price of MOOLEC SCIENCE SA (NASDAQ:MLEC) is experiencing a decline of 16.26%, reaching $0.22 in today's pre-market session on Wednesday. The stock is trading 36.45% lower than a month ago.
AXIL	-14.57%	AXIL BRANDS INC's (NYSEARCA:AXIL) shares experienced a 14.57% decline, falling to $5.83 during Wednesday's pre-market session. In the last month the stock gained 35.23%.
OTLK	-14.21%	Wednesday's pre-market session showed a 14.21% decrease in the stock price of OUTLOOK THERAPEUTICS INC (NASDAQ:OTLK), reaching $1.6. In the last 3 months the stock gained 75.94%.
JTAI	-13.97%	JET.AI INC's (NASDAQ:JTAI) shares fell 13.97% to $0.56 during Wednesday's pre-market session. In the last month the share price dropped with 62.57%.
LXRX	-12.17%	The stock price of LEXICON PHARMACEUTICALS INC (NASDAQ:LXRX) is experiencing a decline of 12.17%, reaching $1.01 in today's pre-market session on Wednesday. Shareholders saw the stock price going 27.64% higher is the past 6 months.
TVRD	-11.11%	TVARDI THERAPEUTICS INC's (NASDAQ:TVRD) stock price decreased by 11.11% to $3.76. The stock is trading 89.49% lower than 3 months ago.
EKSO	-10.54%	During Wednesday's pre-market session, the shares of EKSO BIONICS HOLDINGS INC (NASDAQ:EKSO) declined by 10.54%, reaching $9.46. The current market conditions exhibit high volatility as EKSO retraces its steps after yesterday's 93.77% gain. A press release (EKSO Stock Alert: Halper Sadeh LLC is Investigating Whether the Merger of EKSO Bionics Holdings, Inc. Is Fair to Shareholders) was released yesterday.
UGP	-10.53%	ULTRAPAR PARTICPAC-SPON ADR's (NYSE:UGP) stock price is declining with 10.53% to a price of $3.4. The stock is trading 48.44% higher than a year ago.
BNRG	-10.41%	Wednesday's pre-market session showed a 10.41% decrease in the stock price of BRENMILLER ENERGY LTD (NASDAQ:BNRG), reaching $0.55. It looks like the bad days are not over yet: yesterday BNRG also declined by -24.38% during the regular session.