Get insights into the top gainers and losers of Wednesday's pre-market session.

By Mill Chart - Last update: Dec 31, 2025

The US market is yet to commence its session on Wednesday, but let's get a preview of the pre-market session and explore the top gainers and losers driving the early market movements.


premarket

Gainers

TickerChangeComment
AFJK51.37%AIMEI HEALTH TECHNOLOGY CO's (NASDAQ:AFJK) stock price is advancing with 51.37% to a price of $125.0. Also in the previous session AFJK had a very good day: shares closed with a 89.19% gain.
NCL50.46%Exciting news for NORTHANN CORP (NYSEARCA:NCL) as their shares soared 50.46% to $0.29 during the pre-market session on Wednesday. Yesterday's NCL closing with a -15.28% loss highlights the price volatility, which continues to be evident in today's pre-market session.
DRCT41.79%Exciting news for DIRECT DIGITAL HOLDINGS IN-A (NASDAQ:DRCT) as their shares soared 41.79% to $0.09 during the pre-market session on Wednesday. After recording a 11.67% gain in the previous session, DRCT maintains its positive trajectory in today's pre-market, with an additional 41.79% increase.
MNTSW38.41%During Wednesday's pre-market session, MOMENTUS INC-CW26 (NASDAQ:MNTSW) experienced a 38.41% increase, with the stock price reaching $0.02. Yesterday's MNTSW closing with a -20.77% loss highlights the price volatility, which continues to be evident in today's pre-market session.
ORIS34.43%ORIENTAL RISE HOLDINGS LTD (NASDAQ:ORIS) experienced an impressive 34.43% increase in share price, reaching $1.64 during the pre-market session on Wednesday. Yesterday the company had a press release: Oriental Rise Holding Limited Signs Non-Binding Letter of Intent to Acquire Hubei Daguan Tea Industry Group.
ISPC28.5%Exciting news for ISPECIMEN INC (NASDAQ:ISPC) as their shares soared 28.5% to $0.38 during the pre-market session on Wednesday. Following a -13.15% loss in the previous session, ISPC displays significant price volatility in today's pre-market session. Yesterday the company had a press release: iSpecimen Inc. Announces Pricing of ~$5.5 Million Private Placement.
NITO21.15%During Wednesday's pre-market session, N2OFF INC (NASDAQ:NITO) experienced a 21.15% increase, with the stock price reaching $1.89. The decline of -12.85% in NITO observed yesterday has sparked a potential bounce-back, as evidenced in today's pre-market session.
IVP20.8%During Wednesday's pre-market trading, INSPIRE VETERINARY PARTNE-A (NASDAQ:IVP) demonstrated strong momentum, with the stock price rising 20.8% to $0.06. Yesterday's gain of 18.48% continues in today's pre-market with 20.8%.
VNDA19.91%During Wednesday's pre-market session, VANDA PHARMACEUTICALS INC (NASDAQ:VNDA) exhibited strong growth, with the stock price climbing 19.91% to $8.43. In the last month the stock gained 40.04%.
RYDE19.72%RYDE GROUP LTD-A's (NYSEARCA:RYDE) stock price is advancing with 19.72% to a price of $0.31. The stock is trading 49.13% lower than a month ago.

To see the full list of premarket gainers you can use our premarket gainers page.

Pre-market losers

TickerChangeComment
SMX-16.4%SMX SECURITY MATTERS PLC's (NASDAQ:SMX) shares fell 16.4% to $43.01 during Wednesday's pre-market session. SMX already had a hard day yesterday: closing -39.43% lower during the regular session. A press release (SMX: Why Luxury, From Denim to Couture, Can't Afford "Trust Me" Anymore) was released yesterday.
MLEC-16.26%The stock price of MOOLEC SCIENCE SA (NASDAQ:MLEC) is experiencing a decline of 16.26%, reaching $0.22 in today's pre-market session on Wednesday. The stock is trading 36.45% lower than a month ago.
AXIL-14.57%AXIL BRANDS INC's (NYSEARCA:AXIL) shares experienced a 14.57% decline, falling to $5.83 during Wednesday's pre-market session. In the last month the stock gained 35.23%.
OTLK-14.21%Wednesday's pre-market session showed a 14.21% decrease in the stock price of OUTLOOK THERAPEUTICS INC (NASDAQ:OTLK), reaching $1.6. In the last 3 months the stock gained 75.94%.
JTAI-13.97%JET.AI INC's (NASDAQ:JTAI) shares fell 13.97% to $0.56 during Wednesday's pre-market session. In the last month the share price dropped with 62.57%.
LXRX-12.17%The stock price of LEXICON PHARMACEUTICALS INC (NASDAQ:LXRX) is experiencing a decline of 12.17%, reaching $1.01 in today's pre-market session on Wednesday. Shareholders saw the stock price going 27.64% higher is the past 6 months.
TVRD-11.11%TVARDI THERAPEUTICS INC's (NASDAQ:TVRD) stock price decreased by 11.11% to $3.76. The stock is trading 89.49% lower than 3 months ago.
EKSO-10.54%During Wednesday's pre-market session, the shares of EKSO BIONICS HOLDINGS INC (NASDAQ:EKSO) declined by 10.54%, reaching $9.46. The current market conditions exhibit high volatility as EKSO retraces its steps after yesterday's 93.77% gain. A press release (EKSO Stock Alert: Halper Sadeh LLC is Investigating Whether the Merger of EKSO Bionics Holdings, Inc. Is Fair to Shareholders) was released yesterday.
UGP-10.53%ULTRAPAR PARTICPAC-SPON ADR's (NYSE:UGP) stock price is declining with 10.53% to a price of $3.4. The stock is trading 48.44% higher than a year ago.
BNRG-10.41%Wednesday's pre-market session showed a 10.41% decrease in the stock price of BRENMILLER ENERGY LTD (NASDAQ:BNRG), reaching $0.55. It looks like the bad days are not over yet: yesterday BNRG also declined by -24.38% during the regular session.

For the full premarket loser list go to our premarket losers page.

NORTHANN CORP

NYSEARCA:NCL (2/26/2026, 4:47:44 PM)

0.17

-0.01 (-6.08%)


LEXICON PHARMACEUTICALS INC

NASDAQ:LXRX (2/26/2026, 5:16:02 PM)

After market: 1.5 0 (0%)

1.5

0 (0%)


VANDA PHARMACEUTICALS INC

NASDAQ:VNDA (2/26/2026, 5:17:10 PM)

After market: 8.63 +0.03 (+0.35%)

8.6

+0.32 (+3.86%)


ULTRAPAR PARTICPAC-SPON ADR

NYSE:UGP (2/26/2026, 5:05:00 PM)

After market: 5.19 0 (0%)

5.19

-0.02 (-0.38%)


EKSO BIONICS HOLDINGS INC

NASDAQ:EKSO (2/26/2026, 4:30:02 PM)

10.02

+0.38 (+3.94%)


OUTLOOK THERAPEUTICS INC

NASDAQ:OTLK (2/26/2026, 5:13:27 PM)

After market: 0.4372 +0 (+0.9%)

0.4333

-0.01 (-1.46%)


ISPECIMEN INC

NASDAQ:ISPC (2/26/2026, 4:37:01 PM)

0.275

0 (-1.08%)


MOMENTUS INC-CW26

NASDAQ:MNTSW (2/26/2026, 4:30:00 PM)

0.0127

0 (-13.61%)


DIRECT DIGITAL HOLDINGS IN-A

NASDAQ:DRCT (2/26/2026, 5:01:08 PM)

After market: 0.95 +0.03 (+3.26%)

0.92

-0.03 (-3.41%)


BRENMILLER ENERGY LTD

NASDAQ:BNRG (2/26/2026, 5:13:40 PM)

1.22

-0.02 (-1.61%)


MOOLEC SCIENCE SA

NASDAQ:MLEC (2/26/2026, 5:02:56 PM)

After market: 15.01 -0.31 (-2.02%)

15.32

-0.81 (-5.02%)


SMX SECURITY MATTERS PLC

NASDAQ:SMX (2/26/2026, 4:58:17 PM)

36.28

-4.18 (-10.33%)


JET.AI INC

NASDAQ:JTAI (2/26/2026, 5:18:06 PM)

After market: 0.1137 0 (-1.04%)

0.1149

-0.01 (-6.81%)


INSPIRE VETERINARY PARTNE-A

NASDAQ:IVP (1/20/2026, 8:00:02 PM)

After market: 0.0305 0 (-10.29%)

0.034

-0.01 (-16.05%)


AIMEI HEALTH TECHNOLOGY CO

NASDAQ:AFJK (2/26/2026, 5:10:19 PM)

32.31

+0.24 (+0.75%)


AXIL BRANDS INC

NYSEARCA:AXIL (2/26/2026, 4:15:00 PM)

7

+0.62 (+9.72%)


RYDE GROUP LTD-A

NYSEARCA:RYDE (2/26/2026, 5:15:33 PM)

After market: 0.23 -0.01 (-4.17%)

0.24

+0.01 (+4.8%)


N2OFF INC

NASDAQ:NITO (2/25/2026, 8:00:02 PM)

After market: 1.2697 +0.05 (+4.07%)

1.22

+0.34 (+38.64%)


ORIENTAL RISE HOLDINGS LTD

NASDAQ:ORIS (2/26/2026, 4:50:49 PM)

After market: 1.12 0 (0%)

1.12

-0.03 (-2.61%)


TVARDI THERAPEUTICS INC

NASDAQ:TVRD (2/26/2026, 4:30:02 PM)

4.05

+0.2 (+5.19%)



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