| Feb 19, 2026 | Sachdev Amit | Option Excercise | 48505 | 172.06 | $ 8,345,753.81 |
| Feb 19, 2026 | Sachdev Amit | Open Market Sale | 58613 | 468.83 | $ 27,479,583.09 |
| Feb 18, 2026 | LEIDEN JEFFREY M | Option Excercise | 2964 | 483.75 | $ 1,433,835.00 |
| Feb 17, 2026 | Bozic Carmen | Option Excercise | 1912 | 483.75 | $ 924,930.00 |
| Feb 17, 2026 | Biller Jonathan | Grant | 4135 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Biller Jonathan | Option Excercise | 1505 | 483.75 | $ 728,043.75 |
| Feb 17, 2026 | Biller Jonathan | Open Market Sale | 3720 | 484.18 | $ 1,801,160.88 |
| Feb 17, 2026 | Atkinson Edward Morrow III | Grant | 4962 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Atkinson Edward Morrow III | Option Excercise | 1530 | 483.75 | $ 740,137.50 |
| Feb 17, 2026 | Atkinson Edward Morrow III | Open Market Sale | 2848 | 484.93 | $ 1,381,089.82 |
| Feb 17, 2026 | Ambrose Kristen | Grant | 1809 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Ambrose Kristen | Option Excercise | 598 | 483.75 | $ 289,282.50 |
| Feb 17, 2026 | Ambrose Kristen | Open Market Sale | 2195 | 484.87 | $ 1,064,297.06 |
| Feb 17, 2026 | WAGNER CHARLES F JR | Grant | 7365 | 0.00 | $ 0.00 |
| Feb 17, 2026 | WAGNER CHARLES F JR | Option Excercise | 2294 | 483.75 | $ 1,109,722.50 |
| Feb 17, 2026 | Tatsis Ourania | Grant | 5789 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Tatsis Ourania | Option Excercise | 2294 | 483.75 | $ 1,109,722.50 |
| Feb 17, 2026 | Tatsis Ourania | Open Market Sale | 977 | 483.52 | $ 472,395.38 |
| Feb 17, 2026 | Sachdev Amit | Grant | 5789 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Sachdev Amit | Option Excercise | 2140 | 483.75 | $ 1,035,225.00 |
| Feb 17, 2026 | McKechnie Duncan | Grant | 4962 | 0.00 | $ 0.00 |
| Feb 17, 2026 | McKechnie Duncan | Option Excercise | 1148 | 483.75 | $ 555,345.00 |
| Feb 17, 2026 | LEIDEN JEFFREY M | Grant | 8269 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Kewalramani Reshma | Grant | 16326 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Kewalramani Reshma | Option Excercise | 6554 | 483.75 | $ 3,170,497.50 |
| Feb 17, 2026 | Bunnage Mark E. | Grant | 2584 | 0.00 | $ 0.00 |
| Feb 17, 2026 | Bunnage Mark E. | Option Excercise | 1110 | 483.75 | $ 536,962.50 |
| Feb 17, 2026 | Bunnage Mark E. | Open Market Sale | 3619 | 484.31 | $ 1,752,703.78 |
| Feb 17, 2026 | Bozic Carmen | Grant | 5375 | 0.00 | $ 0.00 |
| Feb 13, 2026 | Atkinson Edward Morrow III | Option Excercise | 1903 | 487.76 | $ 928,207.28 |
| Feb 13, 2026 | Ambrose Kristen | Option Excercise | 1393 | 487.76 | $ 679,449.68 |
| Feb 13, 2026 | Kewalramani Reshma | Option Excercise | 13041 | 487.76 | $ 6,360,878.16 |
| Feb 13, 2026 | Bunnage Mark E. | Option Excercise | 2283 | 487.76 | $ 1,113,556.08 |
| Feb 13, 2026 | Bozic Carmen | Option Excercise | 3804 | 487.76 | $ 1,855,439.04 |
| Feb 13, 2026 | Biller Jonathan | Option Excercise | 2993 | 487.76 | $ 1,459,865.68 |
| Feb 13, 2026 | Biller Jonathan | Open Market Sale | 988 | 499.00 | $ 493,012.00 |
| Feb 13, 2026 | Bhatia Sangeeta N. | Open Market Sale | 266 | 500.00 | $ 133,000.00 |
| Feb 13, 2026 | WAGNER CHARLES F JR | Option Excercise | 4565 | 487.76 | $ 2,226,624.40 |
| Feb 13, 2026 | Tatsis Ourania | Option Excercise | 3804 | 487.76 | $ 1,855,439.04 |
| Feb 13, 2026 | Tatsis Ourania | Open Market Sale | 1500 | 499.99 | $ 749,985.00 |
| Feb 13, 2026 | Sachdev Amit | Option Excercise | 3548 | 487.76 | $ 1,730,572.48 |
| Feb 13, 2026 | McKechnie Duncan | Option Excercise | 2283 | 487.76 | $ 1,113,556.08 |
| Feb 11, 2026 | Atkinson Edward Morrow III | Open Market Sale | 1751 | 460.43 | $ 806,212.93 |
| Feb 11, 2026 | Ambrose Kristen | Open Market Sale | 1376 | 460.43 | $ 633,551.68 |
| Feb 11, 2026 | Bunnage Mark E. | Open Market Sale | 2021 | 460.43 | $ 930,529.03 |
| Feb 11, 2026 | Biller Jonathan | Open Market Sale | 1925 | 460.43 | $ 886,327.75 |
| Feb 11, 2026 | Tatsis Ourania | Open Market Sale | 466 | 460.43 | $ 214,560.38 |
| Feb 10, 2026 | Sachdev Amit | Option Excercise | 2057 | 468.41 | $ 963,519.37 |
| Feb 10, 2026 | McKechnie Duncan | Option Excercise | 1127 | 468.41 | $ 527,898.07 |
| Feb 10, 2026 | Kewalramani Reshma | Option Excercise | 8297 | 468.41 | $ 3,886,397.77 |
| Feb 10, 2026 | Bunnage Mark E. | Option Excercise | 1127 | 468.41 | $ 527,898.07 |
| Feb 10, 2026 | Bozic Carmen | Option Excercise | 2145 | 468.41 | $ 1,004,739.45 |
| Feb 10, 2026 | Biller Jonathan | Option Excercise | 1630 | 468.41 | $ 763,508.30 |
| Feb 10, 2026 | WAGNER CHARLES F JR | Option Excercise | 3045 | 468.41 | $ 1,426,308.45 |
| Feb 10, 2026 | Tatsis Ourania | Option Excercise | 2140 | 468.41 | $ 1,002,397.40 |
| Feb 10, 2026 | Atkinson Edward Morrow III | Option Excercise | 872 | 468.41 | $ 408,453.52 |
| Feb 10, 2026 | Ambrose Kristen | Option Excercise | 592 | 468.41 | $ 277,298.72 |
| Jan 22, 2026 | Ambrose Kristen | Grant | 4250 | 0.00 | $ 0.00 |
| Jan 22, 2026 | ALTSHULER DAVID | Grant | 11194 | 0.00 | $ 0.00 |
| Jan 22, 2026 | LEIDEN JEFFREY M | Grant | 9012 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Kewalramani Reshma | Grant | 38857 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Bozic Carmen | Grant | 11333 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Biller Jonathan | Grant | 9068 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Atkinson Edward Morrow III | Grant | 7817 | 0.00 | $ 0.00 |
| Jan 22, 2026 | WAGNER CHARLES F JR | Grant | 13600 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Tatsis Ourania | Grant | 11749 | 0.00 | $ 0.00 |
| Jan 22, 2026 | Sachdev Amit | Grant | 11749 | 0.00 | $ 0.00 |
| Jan 22, 2026 | McKechnie Duncan | Grant | 6800 | 0.00 | $ 0.00 |
| Jan 7, 2026 | Tatsis Ourania | Open Market Sale | 4500 | 474.99 | $ 2,137,455.00 |
| Jan 6, 2026 | WAGNER CHARLES F JR | Option Excercise | 9532 | 189.38 | $ 1,805,170.16 |
| Jan 6, 2026 | WAGNER CHARLES F JR | Open Market Sale | 9532 | 461.00 | $ 4,394,252.00 |
| Dec 3, 2025 | LEIDEN JEFFREY M | Option Excercise | 63782 | 86.52 | $ 5,518,423.17 |
| Dec 3, 2025 | LEIDEN JEFFREY M | Open Market Sale | 63781 | 449.20 | $ 28,650,336.65 |
| Dec 3, 2025 | Biller Jonathan | Open Market Sale | 347 | 449.00 | $ 155,803.00 |
| Dec 3, 2025 | WAGNER CHARLES F JR | Open Market Sale | 14000 | 456.00 | $ 6,384,000.00 |
| Dec 3, 2025 | Tatsis Ourania | Open Market Sale | 4500 | 449.99 | $ 2,024,955.00 |
| Nov 19, 2025 | CARNEY LLOYD | Other Disposition | 800 | 0.00 | $ 0.00 |
| Nov 17, 2025 | Atkinson Edward Morrow III | Open Market Sale | 2500 | 434.58 | $ 1,086,450.00 |
| Nov 13, 2025 | LEIDEN JEFFREY M | Option Excercise | 73292 | 88.59 | $ 6,493,083.03 |
| Nov 13, 2025 | LEIDEN JEFFREY M | Open Market Sale | 73292 | 440.60 | $ 32,292,319.86 |
| Oct 2, 2025 | Biller Jonathan | Open Market Sale | 694 | 404.21 | $ 280,521.74 |
| Oct 1, 2025 | Biller Jonathan | Option Excercise | 1259 | 400.00 | $ 503,600.00 |
| Aug 27, 2025 | Bhatia Sangeeta N. | Open Market Sale | 266 | 386.69 | $ 102,859.54 |
| Aug 6, 2025 | SACHS BRUCE I | Open Market Purchase | 5000 | 389.68 | $ 1,948,415.68 |
| Aug 6, 2025 | Kewalramani Reshma | Open Market Purchase | 10000 | 389.58 | $ 3,895,767.70 |
| Jul 1, 2025 | Arbuckle Stuart A | Option Excercise | 37243 | 450.23 | $ 16,767,915.89 |
| May 15, 2025 | ALTSHULER DAVID | Open Market Sale | 52 | 424.69 | $ 22,083.88 |
| May 13, 2025 | Arbuckle Stuart A | Grant | 37622 | 0.00 | $ 0.00 |
| May 2, 2025 | Bhatia Sangeeta N. | Open Market Sale | 400 | 505.86 | $ 202,344.00 |
| May 1, 2025 | CARNEY LLOYD | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Bhatia Sangeeta N. | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Garber Alan M | Grant | 398 | 0.00 | $ 0.00 |
| May 1, 2025 | Upadhyay Suketu | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Upadhyay Suketu | Other Disposition | 1001 | | $ 0.00 |
| May 1, 2025 | Thornberry Nancy | Grant | 398 | 0.00 | $ 0.00 |
| May 1, 2025 | Schneider Jennifer | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | MCKENZIE DIANA | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | MCKENZIE DIANA | Other Disposition | 1001 | | $ 0.00 |
| Mar 13, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 510.00 | $ 1,647,810.00 |
| Mar 10, 2025 | WAGNER CHARLES F JR | Open Market Sale | 3298 | 500.00 | $ 1,649,000.00 |
| Mar 10, 2025 | Tatsis Ourania | Open Market Sale | 3242 | 499.99 | $ 1,620,967.58 |
| Mar 10, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 500.00 | $ 1,615,500.00 |
| Mar 4, 2025 | Tatsis Ourania | Open Market Sale | 4058 | 485.49 | $ 1,970,118.42 |
| Mar 3, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 490.00 | $ 1,583,190.00 |