| Oct 2, 2025 | Biller Jonathan | Open Market Sale | 694 | 404.21 | $ 280,521.74 |
| Oct 1, 2025 | Biller Jonathan | Option Excercise | 1259 | 400.00 | $ 503,600.00 |
| Aug 27, 2025 | Bhatia Sangeeta N. | Open Market Sale | 266 | 386.69 | $ 102,859.54 |
| Aug 6, 2025 | SACHS BRUCE I | Open Market Purchase | 5000 | 389.68 | $ 1,948,415.68 |
| Aug 6, 2025 | Kewalramani Reshma | Open Market Purchase | 10000 | 389.58 | $ 3,895,767.70 |
| Jul 1, 2025 | Arbuckle Stuart A | Option Excercise | 37243 | 450.23 | $ 16,767,915.89 |
| May 15, 2025 | ALTSHULER DAVID | Open Market Sale | 52 | 424.69 | $ 22,083.88 |
| May 13, 2025 | Arbuckle Stuart A | Grant | 37622 | 0.00 | $ 0.00 |
| May 2, 2025 | Bhatia Sangeeta N. | Open Market Sale | 400 | 505.86 | $ 202,344.00 |
| May 1, 2025 | CARNEY LLOYD | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Bhatia Sangeeta N. | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Garber Alan M | Grant | 398 | 0.00 | $ 0.00 |
| May 1, 2025 | Upadhyay Suketu | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | Upadhyay Suketu | Other Disposition | 1001 | | $ 0.00 |
| May 1, 2025 | Thornberry Nancy | Grant | 398 | 0.00 | $ 0.00 |
| May 1, 2025 | Schneider Jennifer | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | MCKENZIE DIANA | Grant | 796 | 0.00 | $ 0.00 |
| May 1, 2025 | MCKENZIE DIANA | Other Disposition | 1001 | | $ 0.00 |
| Mar 13, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 510.00 | $ 1,647,810.00 |
| Mar 10, 2025 | WAGNER CHARLES F JR | Open Market Sale | 3298 | 500.00 | $ 1,649,000.00 |
| Mar 10, 2025 | Tatsis Ourania | Open Market Sale | 3242 | 499.99 | $ 1,620,967.58 |
| Mar 10, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 500.00 | $ 1,615,500.00 |
| Mar 4, 2025 | Tatsis Ourania | Open Market Sale | 4058 | 485.49 | $ 1,970,118.42 |
| Mar 3, 2025 | ALTSHULER DAVID | Open Market Sale | 3231 | 490.00 | $ 1,583,190.00 |
| Feb 27, 2025 | Atkinson Edward Morrow III | Open Market Sale | 2650 | 475.34 | $ 1,259,651.00 |
| Feb 27, 2025 | ALTSHULER DAVID | Open Market Sale | 1272 | 480.00 | $ 610,560.00 |
| Feb 27, 2025 | Tatsis Ourania | Open Market Sale | 530 | 475.34 | $ 251,930.20 |
| Feb 26, 2025 | Arbuckle Stuart A | Option Excercise | 7071 | 479.61 | $ 3,391,322.31 |
| Feb 26, 2025 | Ambrose Kristen | Option Excercise | 1241 | 479.61 | $ 595,196.01 |
| Feb 26, 2025 | ALTSHULER DAVID | Option Excercise | 5954 | 479.61 | $ 2,855,597.94 |
| Feb 26, 2025 | WAGNER CHARLES F JR | Option Excercise | 4962 | 479.61 | $ 2,379,824.82 |
| Feb 26, 2025 | Tatsis Ourania | Option Excercise | 4962 | 479.61 | $ 2,379,824.82 |
| Feb 26, 2025 | Sachdev Amit | Option Excercise | 3703 | 479.61 | $ 1,775,995.83 |
| Feb 26, 2025 | Kewalramani Reshma | Option Excercise | 14079 | 479.61 | $ 6,752,429.19 |
| Feb 26, 2025 | Bozic Carmen | Option Excercise | 4962 | 479.61 | $ 2,379,824.82 |
| Feb 26, 2025 | Atkinson Edward Morrow III | Option Excercise | 2482 | 479.61 | $ 1,190,392.02 |
| Feb 25, 2025 | Ambrose Kristen | Open Market Sale | 884 | 480.95 | $ 425,159.80 |
| Feb 25, 2025 | ALTSHULER DAVID | Open Market Sale | 848 | 480.95 | $ 407,845.60 |
| Feb 25, 2025 | Tatsis Ourania | Open Market Sale | 354 | 480.95 | $ 170,256.30 |
| Feb 25, 2025 | Atkinson Edward Morrow III | Open Market Sale | 1767 | 480.95 | $ 849,838.65 |
| Feb 24, 2025 | Arbuckle Stuart A | Option Excercise | 4716 | 483.28 | $ 2,279,148.48 |
| Feb 24, 2025 | Ambrose Kristen | Option Excercise | 828 | 483.28 | $ 400,155.84 |
| Feb 24, 2025 | ALTSHULER DAVID | Option Excercise | 3971 | 483.28 | $ 1,919,104.88 |
| Feb 24, 2025 | WAGNER CHARLES F JR | Option Excercise | 3310 | 483.28 | $ 1,599,656.80 |
| Feb 24, 2025 | Tatsis Ourania | Option Excercise | 3310 | 483.28 | $ 1,599,656.80 |
| Feb 24, 2025 | Sachdev Amit | Option Excercise | 2470 | 483.28 | $ 1,193,701.60 |
| Feb 24, 2025 | Kewalramani Reshma | Option Excercise | 9386 | 483.28 | $ 4,536,066.08 |
| Feb 24, 2025 | Bozic Carmen | Option Excercise | 3310 | 483.28 | $ 1,599,656.80 |
| Feb 24, 2025 | Atkinson Edward Morrow III | Option Excercise | 1656 | 483.28 | $ 800,311.68 |
| Feb 20, 2025 | ALTSHULER DAVID | Open Market Sale | 1111 | 480.00 | $ 533,280.00 |
| Feb 18, 2025 | Biller Jonathan | Open Market Sale | 1657 | 455.06 | $ 754,034.42 |
| Feb 18, 2025 | Ambrose Kristen | Open Market Sale | 671 | 455.06 | $ 305,345.26 |
| Feb 18, 2025 | Tatsis Ourania | Open Market Sale | 244 | 455.06 | $ 111,034.64 |
| Feb 14, 2025 | Bozic Carmen | Option Excercise | 1912 | 463.46 | $ 886,135.52 |
| Feb 14, 2025 | Biller Jonathan | Option Excercise | 1504 | 463.46 | $ 697,043.84 |
| Feb 14, 2025 | Atkinson Edward Morrow III | Option Excercise | 1529 | 463.46 | $ 708,630.34 |
| Feb 14, 2025 | Arbuckle Stuart A | Option Excercise | 2724 | 463.46 | $ 1,262,465.04 |
| Feb 14, 2025 | Ambrose Kristen | Option Excercise | 564 | 463.46 | $ 261,391.44 |
| Feb 14, 2025 | ALTSHULER DAVID | Option Excercise | 2293 | 463.46 | $ 1,062,713.78 |
| Feb 14, 2025 | WAGNER CHARLES F JR | Option Excercise | 2293 | 463.46 | $ 1,062,713.78 |
| Feb 14, 2025 | Tatsis Ourania | Option Excercise | 2293 | 463.46 | $ 1,062,713.78 |
| Feb 14, 2025 | Sachdev Amit | Option Excercise | 2139 | 463.46 | $ 991,340.94 |
| Feb 14, 2025 | LEIDEN JEFFREY M | Option Excercise | 6066 | 463.46 | $ 2,811,348.36 |
| Feb 14, 2025 | Kewalramani Reshma | Option Excercise | 6553 | 463.46 | $ 3,037,053.38 |
| Feb 13, 2025 | LEIDEN JEFFREY M | Option Excercise | 2525 | 450.83 | $ 1,138,345.75 |
| Feb 12, 2025 | Tatsis Ourania | Grant | 6211 | 0.00 | $ 0.00 |
| Feb 12, 2025 | LEIDEN JEFFREY M | Grant | 7209 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Sachdev Amit | Grant | 6211 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Kewalramani Reshma | Grant | 19015 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Bozic Carmen | Grant | 5546 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Biller Jonathan | Grant | 4437 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Atkinson Edward Morrow III | Grant | 6211 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Arbuckle Stuart A | Grant | 7903 | 0.00 | $ 0.00 |
| Feb 12, 2025 | Ambrose Kristen | Grant | 2080 | 0.00 | $ 0.00 |
| Feb 12, 2025 | ALTSHULER DAVID | Grant | 5324 | 0.00 | $ 0.00 |
| Feb 12, 2025 | WAGNER CHARLES F JR | Grant | 6655 | 0.00 | $ 0.00 |
| Feb 11, 2025 | Atkinson Edward Morrow III | Open Market Sale | 1747 | 459.83 | $ 803,323.01 |
| Feb 11, 2025 | Ambrose Kristen | Open Market Sale | 1376 | 459.83 | $ 632,726.08 |
| Feb 11, 2025 | Biller Jonathan | Open Market Sale | 3433 | 459.87 | $ 1,578,733.71 |
| Feb 11, 2025 | Tatsis Ourania | Open Market Sale | 310 | 459.83 | $ 142,547.30 |
| Feb 10, 2025 | Atkinson Edward Morrow III | Option Excercise | 876 | 467.98 | $ 409,950.48 |
| Feb 10, 2025 | Arbuckle Stuart A | Option Excercise | 3220 | 467.98 | $ 1,506,895.60 |
| Feb 10, 2025 | Ambrose Kristen | Option Excercise | 591 | 467.98 | $ 276,576.18 |
| Feb 10, 2025 | ALTSHULER DAVID | Option Excercise | 2142 | 467.98 | $ 1,002,413.16 |
| Feb 10, 2025 | Kewalramani Reshma | Option Excercise | 8300 | 467.98 | $ 3,884,234.00 |
| Feb 10, 2025 | Bozic Carmen | Option Excercise | 2142 | 467.98 | $ 1,002,413.16 |
| Feb 10, 2025 | Biller Jonathan | Option Excercise | 1632 | 467.98 | $ 763,743.36 |
| Feb 10, 2025 | WAGNER CHARLES F JR | Option Excercise | 2649 | 467.98 | $ 1,239,679.02 |
| Feb 10, 2025 | Tatsis Ourania | Option Excercise | 2143 | 467.98 | $ 1,002,881.14 |
| Feb 10, 2025 | Sachdev Amit | Option Excercise | 2056 | 467.98 | $ 962,166.88 |
| Feb 4, 2025 | Atkinson Edward Morrow III | Grant | 9876 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Arbuckle Stuart A | Grant | 23072 | 0.00 | $ 0.00 |
| Feb 4, 2025 | WAGNER CHARLES F JR | Grant | 17376 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Tatsis Ourania | Grant | 17376 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Sachdev Amit | Grant | 15324 | 0.00 | $ 0.00 |
| Feb 4, 2025 | LEIDEN JEFFREY M | Grant | 15414 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Kewalramani Reshma | Grant | 49446 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Bozic Carmen | Grant | 16190 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Biller Jonathan | Grant | 4744 | 0.00 | $ 0.00 |
| Feb 4, 2025 | Ambrose Kristen | Grant | 4420 | 0.00 | $ 0.00 |
| Feb 4, 2025 | ALTSHULER DAVID | Grant | 19428 | 0.00 | $ 0.00 |
| Nov 15, 2024 | ALTSHULER DAVID | Open Market Sale | 15 | 478.56 | $ 7,178.40 |