| Nov 21, 2025 | WENTWORTH KORY JAMES | Open Market Sale | 8910 | 9.98 | $ 88,931.60 |
| Nov 20, 2025 | BAKER BROS. ADVISORS LP | Open Market Purchase | 28867 | 9.07 | $ 261,846.12 |
| Nov 20, 2025 | Baker Bros. Advisors (GP) LLC | Open Market Purchase | 28867 | 9.07 | $ 261,846.12 |
| Nov 20, 2025 | BAKER FELIX | Open Market Purchase | 28867 | 9.07 | $ 261,846.12 |
| Nov 20, 2025 | BAKER JULIAN | Open Market Purchase | 28867 | 9.07 | $ 261,846.12 |
| Nov 14, 2025 | PARMAR KUSH | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | 5AM Ventures V, L.P. | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | 5AM Partners V, LLC | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | 5AM Opportunities I, L.P. | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | 5AM Opportunities I (GP), LLC | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | ROCKLAGE SCOTT M | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 14, 2025 | Schwab Andrew J. | Open Market Sale | 200000 | 8.80 | $ 1,760,000.00 |
| Nov 10, 2025 | BAKER BROS. ADVISORS LP | Open Market Purchase | 178044 | 7.60 | $ 1,352,586.68 |
| Nov 10, 2025 | Baker Bros. Advisors (GP) LLC | Open Market Purchase | 178044 | 7.60 | $ 1,352,586.68 |
| Nov 10, 2025 | BAKER FELIX | Open Market Purchase | 178044 | 7.60 | $ 1,352,586.68 |
| Nov 10, 2025 | BAKER JULIAN | Open Market Purchase | 178044 | 7.60 | $ 1,352,586.68 |
| Sep 2, 2025 | Doshi Dipal | Option Excercise | 8723 | 5.43 | $ 47,367.63 |
| Sep 2, 2025 | Dowden Nathan J | Option Excercise | 1746 | 5.43 | $ 9,481.13 |
| Sep 2, 2025 | Sethuraman Natarajan | Option Excercise | 1760 | 5.43 | $ 9,557.15 |
| Sep 2, 2025 | WENTWORTH KORY JAMES | Option Excercise | 1734 | 5.43 | $ 9,415.97 |
| Jul 9, 2025 | 5AM Opportunities I (GP), LLC | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | ROCKLAGE SCOTT M | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | Schwab Andrew J. | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | PARMAR KUSH | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | 5AM Ventures V, L.P. | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | 5AM Partners V, LLC | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jul 9, 2025 | 5AM Opportunities I, L.P. | Open Market Sale | 27000 | 7.50 | $ 202,554.00 |
| Jun 27, 2025 | PARMAR KUSH | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | 5AM Ventures V, L.P. | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | 5AM Partners V, LLC | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | 5AM Opportunities I, L.P. | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | 5AM Opportunities I (GP), LLC | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | ROCKLAGE SCOTT M | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Jun 27, 2025 | Schwab Andrew J. | Open Market Sale | 125000 | 6.93 | $ 866,632.50 |
| Apr 3, 2025 | WENTWORTH KORY JAMES | Option Excercise | 11134 | 2.10 | $ 23,381.40 |
| Mar 17, 2025 | WENTWORTH KORY JAMES | Open Market Sale | 1784 | 10.67 | $ 19,035.28 |
| Mar 3, 2025 | Doshi Dipal | Option Excercise | 17566 | 11.68 | $ 205,146.29 |
| Mar 3, 2025 | WENTWORTH KORY JAMES | Option Excercise | 4929 | 11.68 | $ 57,563.82 |
| Mar 3, 2025 | Dowden Nathan J | Option Excercise | 5144 | 11.68 | $ 60,074.72 |
| Mar 3, 2025 | Sethuraman Natarajan | Option Excercise | 6138 | 11.68 | $ 71,683.25 |
| Mar 1, 2025 | Doshi Dipal | Grant | 116200 | 0.00 | $ 0.00 |
| Mar 1, 2025 | WENTWORTH KORY JAMES | Grant | 42400 | 0.00 | $ 0.00 |
| Mar 1, 2025 | Dowden Nathan J | Grant | 60800 | 0.00 | $ 0.00 |
| Mar 1, 2025 | Sethuraman Natarajan | Grant | 60800 | 0.00 | $ 0.00 |
| Dec 10, 2024 | MPM BioVentures 2018 GP LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BioVentures 2014, L.P. | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | EVNIN LUKE | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | GADICKE ANSBERT | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | Foley Todd | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BioVentures 2014 (B), L.P. | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM Asset Management Investors BV2014 LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BioVentures 2014 LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BioVentures 2014 GP LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BIOVENTURES 2018 (B), L.P. | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM ASSET MANAGEMENT INVESTORS BV2018 LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BIOVENTURES 2018, L.P. | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 10, 2024 | MPM BioVentures 2018 LLC | Open Market Sale | 44722 | 20.51 | $ 917,110.96 |
| Dec 2, 2024 | WENTWORTH KORY JAMES | Option Excercise | 5000 | 2.10 | $ 10,500.00 |
| Dec 2, 2024 | WENTWORTH KORY JAMES | Open Market Sale | 5000 | 20.00 | $ 99,978.00 |
| Dec 2, 2024 | Sethuraman Natarajan | Open Market Sale | 15791 | 20.18 | $ 318,619.70 |