| Jan 28, 2026 | SCHAFER CAROL | Other Disposition | 8000 | | $ 0.00 |
| Jan 28, 2026 | RHOADS ANN D | Other Disposition | 4000 | | $ 0.00 |
| Jan 28, 2026 | Civik Thomas | Other Disposition | 7500 | | $ 0.00 |
| Jan 28, 2026 | Forte Steve | Other Disposition | 56786 | | $ 0.00 |
| Jan 28, 2026 | Alves Sandra Isabelle Barros | Other Disposition | 31622 | | $ 0.00 |
| Jan 28, 2026 | BVF PARTNERS L P/IL | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BIOTECHNOLOGY VALUE FUND L P | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BVF I GP LLC | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BIOTECHNOLOGY VALUE FUND II LP | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BVF II GP LLC | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | Biotechnology Value Trading Fund OS LP | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BVF Partners OS Ltd. | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BVF GP HOLDINGS LLC | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | BVF INC/IL | Other Disposition | 10166943 | | $ 0.00 |
| Jan 28, 2026 | LAMPERT MARK N | Other Disposition | 10166943 | | $ 0.00 |
| Mar 12, 2025 | Koehler Maria | Open Market Sale | 3596 | 1.14 | $ 4,099.44 |
| Mar 12, 2025 | Zinda Michael | Open Market Sale | 5611 | 1.14 | $ 6,396.54 |
| Mar 12, 2025 | Forte Steve | Open Market Sale | 6884 | 1.14 | $ 7,847.76 |
| Mar 12, 2025 | Segal Lloyd Mitchell | Open Market Sale | 21179 | 1.14 | $ 24,144.06 |
| Mar 4, 2025 | Segal Lloyd Mitchell | Grant | 40000 | 0.00 | $ 0.00 |
| Mar 4, 2025 | Zinda Michael | Grant | 14000 | 0.00 | $ 0.00 |
| Mar 4, 2025 | Forte Steve | Grant | 14000 | 0.00 | $ 0.00 |