| Nov 21, 2025 | Congleton Jon | Option Excercise | 24082 | 0.54 | $ 13,004.28 |
| Nov 20, 2025 | Slingsby Brian Taylor | Open Market Sale | 1000000 | 43.35 | $ 43,350,000.00 |
| Nov 20, 2025 | Catalys Pacific Fund, LP | Open Market Sale | 1000000 | 43.35 | $ 43,350,000.00 |
| Nov 13, 2025 | Karydas Daphne | Option Excercise | 15000 | 10.20 | $ 153,000.00 |
| Nov 13, 2025 | Karydas Daphne | Open Market Sale | 15000 | 45.99 | $ 689,797.08 |
| Nov 11, 2025 | Levy Adam Scott | Open Market Sale | 119524 | 44.88 | $ 5,363,715.88 |
| Nov 11, 2025 | Congleton Jon | Open Market Sale | 200000 | 45.44 | $ 9,088,498.87 |
| Nov 11, 2025 | Gold Alexander M | Option Excercise | 34675 | 10.92 | $ 378,585.00 |
| Nov 11, 2025 | Gold Alexander M | Open Market Sale | 34675 | 45.45 | $ 1,576,094.67 |
| Nov 11, 2025 | Levy Adam Scott | Option Excercise | 105653 | 14.11 | $ 1,490,433.87 |
| Oct 15, 2025 | Rodman David Malcom | Open Market Sale | 10369 | 43.01 | $ 445,982.10 |
| Oct 13, 2025 | Levy Adam Scott | Open Market Sale | 10758 | 42.01 | $ 451,983.56 |
| Oct 13, 2025 | Congleton Jon | Open Market Sale | 15100 | 42.67 | $ 644,326.87 |
| Sep 15, 2025 | Rodman David Malcom | Open Market Sale | 11367 | 36.00 | $ 409,265.98 |
| Sep 4, 2025 | RA CAPITAL MANAGEMENT, LLC | Open Market Purchase | 1176470 | 25.50 | $ 29,999,985.00 |
| Sep 4, 2025 | RA Capital Healthcare Fund LP | Open Market Purchase | 1176470 | 25.50 | $ 29,999,985.00 |
| Sep 4, 2025 | RA Capital Nexus Fund III, L.P. | Open Market Purchase | 1176470 | 25.50 | $ 29,999,985.00 |
| Sep 4, 2025 | Kolchinsky Peter | Open Market Purchase | 1176470 | 25.50 | $ 29,999,985.00 |
| Sep 4, 2025 | Shah Rajeev M. | Open Market Purchase | 1176470 | 25.50 | $ 29,999,985.00 |
| Sep 4, 2025 | AKKARAJU SRINIVAS | Open Market Purchase | 588235 | 25.50 | $ 14,999,992.50 |
| Aug 13, 2025 | Rodman David Malcom | Open Market Sale | 11365 | 12.93 | $ 146,986.95 |
| Aug 12, 2025 | Rodman David Malcom | Option Excercise | 6349 | 1.08 | $ 6,856.92 |
| Jul 28, 2025 | Levy Adam Scott | Open Market Sale | 73678 | 14.62 | $ 1,077,476.77 |
| Jul 14, 2025 | Rodman David Malcom | Option Excercise | 6349 | 1.08 | $ 6,856.92 |
| Jul 14, 2025 | Rodman David Malcom | Open Market Sale | 11366 | 14.59 | $ 165,878.81 |
| Jul 11, 2025 | Levy Adam Scott | Open Market Sale | 10758 | 14.45 | $ 155,454.18 |
| Jul 11, 2025 | Congleton Jon | Open Market Sale | 15884 | 14.51 | $ 230,430.78 |
| Jun 13, 2025 | Rodman David Malcom | Open Market Sale | 11366 | 14.60 | $ 165,931.10 |
| Jun 12, 2025 | Rodman David Malcom | Option Excercise | 6348 | 1.08 | $ 6,855.84 |
| May 14, 2025 | Rodman David Malcom | Open Market Sale | 11366 | 15.29 | $ 173,773.64 |
| May 12, 2025 | Rodman David Malcom | Option Excercise | 6349 | 1.08 | $ 6,856.92 |
| Apr 14, 2025 | Rodman David Malcom | Option Excercise | 6348 | 1.08 | $ 6,855.84 |
| Apr 14, 2025 | Rodman David Malcom | Open Market Sale | 11366 | 14.53 | $ 165,185.14 |
| Apr 11, 2025 | Levy Adam Scott | Open Market Sale | 10757 | 12.06 | $ 129,684.24 |
| Apr 11, 2025 | Congleton Jon | Open Market Sale | 15319 | 12.19 | $ 186,802.95 |
| Apr 1, 2025 | Rodman David Malcom | Option Excercise | 1606 | 1.08 | $ 1,734.48 |
| Apr 1, 2025 | Rodman David Malcom | Open Market Sale | 55771 | 15.76 | $ 879,008.48 |
| Mar 13, 2025 | Shah Rajeev M. | Open Market Purchase | 1296296 | 13.50 | $ 17,499,996.00 |
| Mar 13, 2025 | Samsara BioCapital GP, LLC | Open Market Purchase | 600000 | 13.50 | $ 8,100,000.00 |
| Mar 13, 2025 | Samsara BioCapital, L.P. | Open Market Purchase | 600000 | 13.50 | $ 8,100,000.00 |
| Mar 13, 2025 | AKKARAJU SRINIVAS | Open Market Purchase | 600000 | 13.50 | $ 8,100,000.00 |
| Mar 13, 2025 | RA CAPITAL MANAGEMENT, LLC | Open Market Purchase | 1296296 | 13.50 | $ 17,499,996.00 |
| Mar 13, 2025 | RA Capital Healthcare Fund LP | Open Market Purchase | 1296296 | 13.50 | $ 17,499,996.00 |
| Mar 13, 2025 | RA Capital Nexus Fund III, L.P. | Open Market Purchase | 1296296 | 13.50 | $ 17,499,996.00 |
| Mar 13, 2025 | Kolchinsky Peter | Open Market Purchase | 1296296 | 13.50 | $ 17,499,996.00 |
| Mar 12, 2025 | Rodman David Malcom | Option Excercise | 6349 | 1.08 | $ 6,856.92 |
| Feb 12, 2025 | Rodman David Malcom | Option Excercise | 6348 | 1.08 | $ 6,855.84 |
| Dec 11, 2024 | Rodman David Malcom | Option Excercise | 5017 | 0.54 | $ 2,709.18 |