| Jan 7, 2026 | Bernstein Harold | Option Excercise | 25156 | 10.42 | $ 262,125.52 |
| Jan 7, 2026 | Bernstein Harold | Open Market Sale | 25156 | 40.20 | $ 1,011,298.87 |
| Jan 6, 2026 | Sohn Catherine A. | Option Excercise | 29413 | 10.42 | $ 306,483.46 |
| Jan 6, 2026 | Sohn Catherine A. | Open Market Sale | 29413 | 39.07 | $ 1,149,054.36 |
| Jan 2, 2026 | Bachrodt Amy | Option Excercise | 5000 | 10.42 | $ 52,100.00 |
| Jan 2, 2026 | Bachrodt Amy | Open Market Sale | 5000 | 39.15 | $ 195,753.59 |
| Jan 2, 2026 | Bernstein Harold | Option Excercise | 4844 | 10.42 | $ 50,474.48 |
| Jan 2, 2026 | Bernstein Harold | Open Market Sale | 4844 | 40.39 | $ 195,667.53 |
| Dec 29, 2025 | Dandekar Atul | Option Excercise | 72500 | 10.42 | $ 755,450.00 |
| Dec 29, 2025 | Dandekar Atul | Open Market Sale | 72500 | 40.56 | $ 2,940,799.44 |
| Dec 29, 2025 | Bernstein Harold | Option Excercise | 45000 | 10.42 | $ 468,900.00 |
| Dec 29, 2025 | Bernstein Harold | Open Market Sale | 45000 | 40.56 | $ 1,825,354.84 |
| Dec 29, 2025 | Bachrodt Amy | Option Excercise | 15000 | 10.42 | $ 156,300.00 |
| Dec 29, 2025 | Bachrodt Amy | Open Market Sale | 15000 | 40.41 | $ 606,173.28 |
| Nov 19, 2025 | HOMCY CHARLES J | Other Aquisition | 1489 | 0.00 | $ 0.00 |
| Nov 4, 2025 | Third Rock Ventures V, L.P. | Other Disposition | 1600000 | | $ 0.00 |
| Nov 4, 2025 | Third Rock Ventures GP V, LP | Other Disposition | 1600000 | | $ 0.00 |
| Nov 4, 2025 | TRV GP V, LLC | Other Disposition | 1600000 | | $ 0.00 |
| Nov 4, 2025 | Third Rock Ventures IV, L.P. | Other Disposition | 1600000 | | $ 0.00 |
| Nov 4, 2025 | Third Rock Ventures GP IV, L.P. | Other Disposition | 1600000 | | $ 0.00 |
| Nov 4, 2025 | TRV GP IV, LLC | Other Disposition | 1600000 | | $ 0.00 |
| Oct 23, 2025 | HOMCY CHARLES J | Other Disposition | 28423 | 0.00 | $ 0.00 |
| Sep 15, 2025 | SCHELLER RICHARD H | Open Market Sale | 20744 | 22.37 | $ 464,034.98 |
| Feb 3, 2025 | Lim Jonathan E | Other Aquisition | 307956 | | $ 0.00 |
| Feb 3, 2025 | HOMCY CHARLES J | Other Aquisition | 36946 | | $ 0.00 |
| Feb 3, 2025 | Third Rock Ventures IV, L.P. | Other Aquisition | 6713588 | 0.00 | $ 0.00 |
| Feb 3, 2025 | Third Rock Ventures GP IV, L.P. | Other Aquisition | 6713588 | 0.00 | $ 0.00 |
| Feb 3, 2025 | TRV GP IV, LLC | Other Aquisition | 6713588 | 0.00 | $ 0.00 |
| Feb 3, 2025 | Third Rock Ventures V, L.P. | Other Aquisition | 6713588 | 0.00 | $ 0.00 |
| Feb 3, 2025 | Third Rock Ventures GP V, LP | Other Aquisition | 6713588 | 0.00 | $ 0.00 |
| Feb 3, 2025 | TRV GP V, LLC | Other Aquisition | 6713588 | 0.00 | $ 0.00 |