| Feb 28, 2026 | McDermott Wendy | Option Excercise | 224406 | | $ 0.00 |
| Feb 28, 2026 | McDermott Wendy | Option Excercise | 68107 | 1.47 | $ 100,117.29 |
| Feb 28, 2026 | Martens Rachel Yap | Option Excercise | 67090 | | $ 0.00 |
| Feb 28, 2026 | Martens Rachel Yap | Option Excercise | 35826 | 1.47 | $ 52,664.22 |
| Feb 28, 2026 | Granowitz Craig B | Option Excercise | 312276 | | $ 0.00 |
| Feb 28, 2026 | Granowitz Craig B | Option Excercise | 109098 | 1.47 | $ 160,374.06 |
| Feb 28, 2026 | Gopinathan Suma | Option Excercise | 99950 | | $ 0.00 |
| Feb 28, 2026 | Gopinathan Suma | Option Excercise | 24338 | 1.47 | $ 35,776.86 |
| Feb 28, 2026 | DeFrancesco Lisa | Option Excercise | 152864 | | $ 0.00 |
| Feb 28, 2026 | DeFrancesco Lisa | Option Excercise | 74572 | 1.47 | $ 109,620.84 |
| Feb 28, 2026 | Crum Brian T | Option Excercise | 273006 | | $ 0.00 |
| Feb 28, 2026 | Crum Brian T | Option Excercise | 105019 | 1.47 | $ 154,377.93 |
| Feb 28, 2026 | Coiante Scott M | Option Excercise | 160237 | | $ 0.00 |
| Feb 28, 2026 | Coiante Scott M | Option Excercise | 54881 | 1.47 | $ 80,675.07 |
| Feb 28, 2026 | Exton Michael | Option Excercise | 503263 | | $ 0.00 |
| Feb 28, 2026 | Exton Michael | Option Excercise | 204831 | 1.47 | $ 301,101.57 |
| Feb 25, 2026 | DEBBANE RAYMOND | Open Market Purchase | 2000 | 1.49 | $ 2,980.00 |
| Feb 23, 2026 | DEBBANE RAYMOND | Open Market Purchase | 100000 | 1.47 | $ 147,000.00 |
| Feb 19, 2026 | DEBBANE RAYMOND | Open Market Purchase | 150000 | 1.47 | $ 219,755.00 |
| Feb 17, 2026 | Artal International Management S.A. | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Artal Group S.A. | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Westend S.A. | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Stichting Administratiekantoor Westend | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Wittouck Amaury | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Artal Participations S.a r.l. | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 17, 2026 | Artal International S.C.A. | Grant | 41290 | 65.00 | $ 2,683,850.00 |
| Feb 13, 2026 | DEBBANE RAYMOND | Open Market Purchase | 268497 | 1.31 | $ 352,889.04 |
| Feb 2, 2026 | Invus Global Management, LLC | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Siren, L.L.C. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | DEBBANE RAYMOND | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Artal Participations S.a r.l. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Artal International S.C.A. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Artal International Management S.A. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Artal Group S.A. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Westend S.A. | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Stichting Administratiekantoor Westend | Grant | 22767145 | 2.33 | $ 52,984,425.00 |
| Feb 2, 2026 | Invus Global Management, LLC | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Siren, L.L.C. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | DEBBANE RAYMOND | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Artal Participations S.a r.l. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Artal International S.C.A. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Artal International Management S.A. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Artal Group S.A. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Westend S.A. | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| Feb 2, 2026 | Stichting Administratiekantoor Westend | Open Market Purchase | 1538462 | 1.30 | $ 2,000,000.60 |
| May 13, 2025 | BARKER SAM L | Option Excercise | 36810 | 0.00 | $ 0.00 |
| May 13, 2025 | Swain Judith L | Option Excercise | 36810 | 0.00 | $ 0.00 |
| May 13, 2025 | Amouyal Philippe | Option Excercise | 36810 | 0.00 | $ 0.00 |
| May 13, 2025 | Sullivan Diane E. | Option Excercise | 36810 | 0.00 | $ 0.00 |
| May 13, 2025 | DEBBANE RAYMOND | Option Excercise | 36810 | 0.00 | $ 0.00 |
| May 13, 2025 | SOBECKI CHRISTOPHER J | Option Excercise | 36810 | 0.00 | $ 0.00 |