| Nov 14, 2025 | Meyer Andrew Hollman | Option Excercise | 3333 | 10.59 | $ 35,296.47 |
| Nov 14, 2025 | Meyer Andrew Hollman | Open Market Sale | 3333 | 30.00 | $ 99,990.00 |
| Oct 28, 2025 | Meyer Andrew Hollman | Option Excercise | 16665 | 6.76 | $ 112,688.73 |
| Oct 28, 2025 | Meyer Andrew Hollman | Open Market Sale | 16665 | 30.06 | $ 500,986.56 |
| Jun 11, 2025 | CAPPS VICKIE L | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | DOBMEIER ERIC | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Gujrathi Sheila | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Hernday Natasha | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Kung Winston | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | McNulty Alana B. | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Simson Jake | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | RA CAPITAL MANAGEMENT, LLC | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | RA Capital Healthcare Fund LP | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | RA Capital Nexus Fund II, L.P. | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Kolchinsky Peter | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Shah Rajeev M. | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 11, 2025 | Barrett Ronald W | Grant | 3750 | 0.00 | $ 0.00 |
| Jun 2, 2025 | Doyle Janeen Noel | Grant | 44000 | 0.00 | $ 0.00 |
| May 1, 2025 | Meyer Andrew Hollman | Option Excercise | 3333 | 4.21 | $ 14,031.93 |
| May 1, 2025 | Meyer Andrew Hollman | Open Market Sale | 3333 | 32.03 | $ 106,744.55 |
| Apr 21, 2025 | Meyer Andrew Hollman | Option Excercise | 3334 | 4.21 | $ 14,036.14 |
| Apr 21, 2025 | Meyer Andrew Hollman | Open Market Sale | 3334 | 30.00 | $ 100,020.00 |
| Mar 5, 2025 | RA CAPITAL MANAGEMENT, LLC | Open Market Purchase | 824041 | 30.75 | $ 25,342,964.88 |
| Mar 5, 2025 | RA Capital Healthcare Fund LP | Open Market Purchase | 824041 | 30.75 | $ 25,342,964.88 |
| Mar 5, 2025 | RA Capital Nexus Fund II, L.P. | Open Market Purchase | 824041 | 30.75 | $ 25,342,964.88 |
| Mar 5, 2025 | Kolchinsky Peter | Open Market Purchase | 824041 | 30.75 | $ 25,342,964.88 |
| Mar 5, 2025 | Shah Rajeev M. | Open Market Purchase | 824041 | 30.75 | $ 25,342,964.88 |
| Mar 3, 2025 | Meyer Andrew Hollman | Option Excercise | 3334 | 4.21 | $ 14,036.14 |
| Mar 3, 2025 | Meyer Andrew Hollman | Open Market Sale | 3334 | 32.15 | $ 107,174.38 |
| Feb 3, 2025 | Meyer Andrew Hollman | Option Excercise | 3334 | 4.21 | $ 14,036.14 |
| Feb 3, 2025 | Meyer Andrew Hollman | Open Market Sale | 3334 | 42.29 | $ 140,999.37 |
| Jan 7, 2025 | Campbell David Alan | Open Market Sale | 5000 | 60.00 | $ 300,004.00 |
| Jan 2, 2025 | Meyer Andrew Hollman | Grant | 18000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | Meyer Andrew Hollman | Open Market Sale | 13334 | 54.88 | $ 731,785.25 |
| Jan 2, 2025 | McIver Zachariah | Grant | 26000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | Winter Charles M. | Grant | 23000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | Campbell David Alan | Grant | 81000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | Robinson Byron | Grant | 28000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | DiRaimondo Thomas | Grant | 24000 | 0.00 | $ 0.00 |
| Jan 2, 2025 | Dobek Maria | Grant | 14000 | 0.00 | $ 0.00 |
| Dec 24, 2024 | Campbell David Alan | Open Market Sale | 25000 | 56.19 | $ 1,404,805.00 |
| Dec 19, 2024 | Meyer Andrew Hollman | Option Excercise | 9881 | 20.24 | $ 199,985.22 |
| Dec 3, 2024 | Campbell David Alan | Open Market Sale | 15000 | 67.00 | $ 1,005,000.00 |
| Nov 25, 2024 | Campbell David Alan | Open Market Sale | 25000 | 51.60 | $ 1,289,878.73 |