| Nov 11, 2025 | Yu Jonathan Yen-Wen | Option Excercise | 30000 | 2.65 | $ 79,500.00 |
| Nov 11, 2025 | Yu Jonathan Yen-Wen | Open Market Sale | 30000 | 84.70 | $ 2,540,922.64 |
| Oct 22, 2025 | AI DMI LLC | Open Market Sale | 744047 | 80.47 | $ 59,873,462.09 |
| Oct 22, 2025 | Access Industries Holdings LLC | Open Market Sale | 744047 | 80.47 | $ 59,873,462.09 |
| Oct 22, 2025 | ACCESS INDUSTRIES MANAGEMENT, LLC | Open Market Sale | 744047 | 80.47 | $ 59,873,462.09 |
| Oct 22, 2025 | Blavatnik Len | Open Market Sale | 744047 | 80.47 | $ 59,873,462.09 |
| Oct 15, 2025 | Bitterman Kevin | Open Market Sale | 93585 | 85.97 | $ 8,045,251.74 |
| Oct 7, 2025 | Bitterman Kevin | Open Market Sale | 90000 | 70.14 | $ 6,312,500.51 |
| Sep 9, 2025 | Quisel John D | Option Excercise | 10000 | 1.01 | $ 10,100.00 |
| Aug 22, 2025 | Bitterman Kevin | Open Market Sale | 2287 | 61.03 | $ 139,575.61 |
| Aug 13, 2025 | Bitterman Kevin | Open Market Sale | 32174 | 61.11 | $ 1,966,286.18 |
| Aug 5, 2025 | Bitterman Kevin | Open Market Sale | 395 | 60.95 | $ 24,075.25 |
| Jul 30, 2025 | Bitterman Kevin | Open Market Sale | 8492 | 61.04 | $ 518,351.68 |
| Jul 23, 2025 | Bitterman Kevin | Open Market Sale | 42870 | 61.03 | $ 2,616,390.50 |
| Jul 18, 2025 | Bitterman Kevin | Open Market Sale | 664 | 61.13 | $ 40,590.32 |
| Jul 17, 2025 | Franchi Jean M. | Open Market Sale | 2031 | 59.00 | $ 119,829.00 |
| Jul 10, 2025 | Franchi Jean M. | Open Market Sale | 2000 | 57.50 | $ 115,000.00 |
| Jul 9, 2025 | Quisel John D | Option Excercise | 34800 | 9.86 | $ 343,128.00 |
| Jul 9, 2025 | Quisel John D | Open Market Sale | 34800 | 55.33 | $ 1,925,524.86 |
| Jul 3, 2025 | Quisel John D | Option Excercise | 5200 | 9.86 | $ 51,272.00 |
| Jul 3, 2025 | Quisel John D | Open Market Sale | 5200 | 55.09 | $ 286,454.48 |
| Jun 27, 2025 | Savage William Jacob | Option Excercise | 32070 | 9.86 | $ 316,210.20 |
| Jun 16, 2025 | Franchi Jean M. | Open Market Sale | 2000 | 52.26 | $ 104,518.80 |
| Jun 6, 2025 | Savage William Jacob | Open Market Sale | 2996 | 50.00 | $ 149,800.00 |
| May 20, 2025 | Savage William Jacob | Open Market Sale | 6677 | 50.04 | $ 334,128.43 |
| May 2, 2025 | Savage William Jacob | Open Market Sale | 2100 | 50.17 | $ 105,367.08 |
| Apr 7, 2025 | Quisel John D | Option Excercise | 7000 | 1.01 | $ 7,070.00 |
| Mar 24, 2025 | ORBIMED ADVISORS LLC | Open Market Sale | 5738 | 54.11 | $ 310,483.18 |
| Mar 24, 2025 | OrbiMed Capital GP VI LLC | Open Market Sale | 5738 | 54.11 | $ 310,483.18 |
| Mar 24, 2025 | OrbiMed Capital GP VIII LLC | Open Market Sale | 5738 | 54.11 | $ 310,483.18 |
| Mar 24, 2025 | OrbiMed Genesis GP LLC | Open Market Sale | 5738 | 54.11 | $ 310,483.18 |
| Mar 24, 2025 | Ashiya Mona | Open Market Sale | 5738 | 54.11 | $ 310,483.18 |
| Mar 19, 2025 | ORBIMED ADVISORS LLC | Open Market Sale | 52429 | 54.02 | $ 2,831,986.74 |
| Mar 19, 2025 | OrbiMed Capital GP VI LLC | Open Market Sale | 52429 | 54.02 | $ 2,831,986.74 |
| Mar 19, 2025 | OrbiMed Capital GP VIII LLC | Open Market Sale | 52429 | 54.02 | $ 2,831,986.74 |
| Mar 19, 2025 | OrbiMed Genesis GP LLC | Open Market Sale | 52429 | 54.02 | $ 2,831,986.74 |
| Mar 19, 2025 | Ashiya Mona | Open Market Sale | 52429 | 54.02 | $ 2,831,986.74 |
| Mar 10, 2025 | Ashiya Mona | Open Market Sale | 312384 | 54.31 | $ 16,965,596.07 |
| Mar 10, 2025 | ORBIMED ADVISORS LLC | Open Market Sale | 312384 | 54.31 | $ 16,965,596.07 |
| Mar 10, 2025 | OrbiMed Capital GP VI LLC | Open Market Sale | 312384 | 54.31 | $ 16,965,596.07 |
| Mar 10, 2025 | OrbiMed Capital GP VIII LLC | Open Market Sale | 312384 | 54.31 | $ 16,965,596.07 |
| Mar 10, 2025 | OrbiMed Genesis GP LLC | Open Market Sale | 312384 | 54.31 | $ 16,965,596.07 |
| Feb 18, 2025 | Stephenson Pamela | Open Market Sale | 3137 | 54.58 | $ 171,217.46 |
| Feb 18, 2025 | Khara Rahul | Open Market Sale | 1161 | 54.58 | $ 63,367.38 |
| Feb 18, 2025 | Savage William Jacob | Open Market Sale | 1638 | 54.58 | $ 89,402.04 |
| Feb 18, 2025 | Yu Jonathan Yen-Wen | Open Market Sale | 1610 | 54.58 | $ 87,873.80 |
| Feb 10, 2025 | Stephenson Pamela | Grant | 36000 | 0.00 | $ 0.00 |
| Feb 10, 2025 | Khara Rahul | Grant | 24000 | 0.00 | $ 0.00 |
| Feb 10, 2025 | Yu Jonathan Yen-Wen | Grant | 24000 | 0.00 | $ 0.00 |
| Feb 10, 2025 | Franchi Jean M. | Grant | 36000 | 0.00 | $ 0.00 |
| Feb 10, 2025 | Quisel John D | Grant | 78337 | 0.00 | $ 0.00 |
| Feb 10, 2025 | Savage William Jacob | Grant | 24000 | 0.00 | $ 0.00 |
| Feb 3, 2025 | Khara Rahul | Option Excercise | 7500 | 14.69 | $ 110,175.00 |
| Feb 3, 2025 | Khara Rahul | Open Market Sale | 7500 | 55.54 | $ 416,573.69 |
| Dec 30, 2024 | Quisel John D | Option Excercise | 23012 | 6.01 | $ 138,398.32 |
| Dec 30, 2024 | Quisel John D | Open Market Sale | 13012 | 61.95 | $ 806,057.55 |
| Dec 23, 2024 | Quisel John D | Option Excercise | 19820 | 2.65 | $ 52,523.00 |
| Dec 23, 2024 | Quisel John D | Open Market Sale | 19820 | 63.14 | $ 1,251,357.22 |
| Dec 16, 2024 | Quisel John D | Option Excercise | 12791 | 1.01 | $ 12,918.91 |
| Dec 16, 2024 | Quisel John D | Open Market Sale | 12791 | 66.01 | $ 844,314.09 |