| Oct 27, 2025 | MCCORMICK FRANK | Open Market Sale | 1641 | 65.00 | $ 106,665.00 | 
| Oct 8, 2025 | Kumar Neil | Open Market Sale | 80000 | 54.79 | $ 4,383,442.21 | 
| Sep 5, 2025 | MCCORMICK FRANK | Option Excercise | 74000 | 11.92 | $ 882,080.00 | 
| Sep 5, 2025 | MCCORMICK FRANK | Open Market Sale | 74000 | 53.16 | $ 3,933,544.00 | 
| Sep 4, 2025 | Kumar Neil | Open Market Sale | 80000 | 52.20 | $ 4,175,835.24 | 
| Aug 21, 2025 | Trimarchi Thomas | Open Market Sale | 42237 | 49.48 | $ 2,090,081.05 | 
| Aug 20, 2025 | Kumar Neil | Open Market Sale | 26156 | 48.82 | $ 1,276,927.17 | 
| Aug 18, 2025 | Trimarchi Thomas | Open Market Sale | 17353 | 50.23 | $ 871,722.42 | 
| Aug 16, 2025 | Apuli Maricel | Option Excercise | 4781 | 51.32 | $ 245,360.92 | 
| Aug 16, 2025 | Trimarchi Thomas | Option Excercise | 21317 | 51.32 | $ 1,093,988.44 | 
| Aug 16, 2025 | Kumar Neil | Option Excercise | 64697 |  | $ 0.00 | 
| Aug 16, 2025 | Kumar Neil | Option Excercise | 32855 | 51.32 | $ 1,686,118.60 | 
| Aug 8, 2025 | HOMCY CHARLES J | Open Market Sale | 300000 | 46.37 | $ 13,912,442.76 | 
| Aug 7, 2025 | Kumar Neil | Open Market Sale | 80000 | 45.84 | $ 3,666,949.26 | 
| Aug 7, 2025 | Apuli Maricel | Open Market Sale | 1000 | 45.44 | $ 45,440.00 | 
| Aug 5, 2025 | Ellis Andrea | Option Excercise | 17167 | 16.75 | $ 287,547.25 | 
| Aug 5, 2025 | Ellis Andrea | Open Market Sale | 17167 | 49.00 | $ 841,183.00 | 
| Jul 1, 2025 | Kumar Neil | Open Market Sale | 80000 | 42.63 | $ 3,410,450.42 | 
| Jun 27, 2025 | VIKING GLOBAL INVESTORS LP | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Viking Global Opportunities Parent GP LLC | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Viking Global Opportunities GP LLC | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Viking Global Opportunities Portfolio GP LLC | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Viking Global Opportunities Illiquid Investments Sub-Master LP | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | HALVORSEN OLE ANDREAS | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Ott David C. | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | Shabet Rose Sharon | Open Market Sale | 3500000 | 44.00 | $ 154,000,000.00 | 
| Jun 27, 2025 | HOMCY CHARLES J | Other Disposition | 20000 | 0.00 | $ 0.00 | 
| Jun 26, 2025 | Valantine Hannah | Open Market Sale | 4707 | 44.05 | $ 207,327.26 | 
| Jun 24, 2025 | MCCORMICK FRANK | Open Market Sale | 100000 | 44.23 | $ 4,422,800.00 | 
| Jun 20, 2025 | Hassan Fred | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Dachille Douglas A. | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | MOMTAZEE JAMES C | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | HOMCY CHARLES J | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Valantine Hannah | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Scott Randal W | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Lo Andrew | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Ellis Andrea | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | DANIELS RONALD J | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Satvat Ali J. | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | Cook Jennifer E. | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | MCCORMICK FRANK | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 20, 2025 | AGUIAR ERIC | Grant | 6589 | 0.00 | $ 0.00 | 
| Jun 10, 2025 | Valantine Hannah | Option Excercise | 4292 | 16.75 | $ 71,891.00 | 
| Jun 10, 2025 | Valantine Hannah | Open Market Sale | 4292 | 40.00 | $ 171,680.00 | 
| May 19, 2025 | Kumar Neil | Open Market Sale | 101156 | 33.38 | $ 3,376,741.11 | 
| May 16, 2025 | Trimarchi Thomas | Option Excercise | 21317 | 33.84 | $ 721,367.28 | 
| May 16, 2025 | Apuli Maricel | Option Excercise | 4780 | 33.84 | $ 161,755.20 | 
| May 16, 2025 | Kumar Neil | Option Excercise | 64696 |  | $ 0.00 | 
| May 16, 2025 | Kumar Neil | Option Excercise | 32854 | 33.84 | $ 1,111,779.36 | 
| May 12, 2025 | KKR Genetic Disorder L.P. | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR Genetic Disorder GP LLC | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR Fund Holdings L.P. | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR Group Holdings Corp. | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR Group Co. Inc. | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR & Co. Inc. | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KKR Management LLC | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | KRAVIS HENRY R | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 12, 2025 | ROBERTS GEORGE R | Open Market Sale | 6000000 | 34.20 | $ 205,200,000.00 | 
| May 2, 2025 | Lo Andrew | Open Market Sale | 100000 | 38.50 | $ 3,849,900.00 | 
| May 2, 2025 | Apuli Maricel | Open Market Sale | 1026 | 38.51 | $ 39,509.11 | 
| Apr 22, 2025 | Kumar Neil | Open Market Sale | 75000 | 34.11 | $ 2,558,025.00 | 
| Apr 14, 2025 | Ellis Andrea | Option Excercise | 10000 | 8.45 | $ 84,500.00 | 
| Apr 14, 2025 | Ellis Andrea | Open Market Sale | 10000 | 35.00 | $ 350,000.00 | 
| Apr 1, 2025 | Ellis Andrea | Option Excercise | 30000 | 8.45 | $ 253,500.00 | 
| Apr 1, 2025 | Ellis Andrea | Open Market Sale | 30000 | 34.05 | $ 1,021,500.00 | 
| Mar 25, 2025 | Kumar Neil | Open Market Sale | 75000 | 36.87 | $ 2,764,942.50 | 
| Mar 19, 2025 | Apuli Maricel | Grant | 23660 | 0.00 | $ 0.00 | 
| Mar 19, 2025 | Trimarchi Thomas | Grant | 109100 | 0.00 | $ 0.00 | 
| Mar 6, 2025 | Valantine Hannah | Option Excercise | 12875 | 16.75 | $ 215,656.25 | 
| Mar 6, 2025 | Valantine Hannah | Open Market Sale | 12875 | 32.58 | $ 419,499.69 | 
| Mar 5, 2025 | KKR Genetic Disorder L.P. | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR Genetic Disorder GP LLC | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR Fund Holdings L.P. | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR Group Holdings Corp. | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR Group Co. Inc. | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR & Co. Inc. | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KKR Management LLC | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | KRAVIS HENRY R | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Mar 5, 2025 | ROBERTS GEORGE R | Open Market Sale | 6000000 | 32.96 | $ 197,760,000.00 | 
| Feb 25, 2025 | Kumar Neil | Open Market Sale | 75000 | 33.57 | $ 2,517,971.14 | 
| Feb 25, 2025 | STEPHENSON BRIAN C | Option Excercise | 8500 | 17.00 | $ 144,500.00 | 
| Feb 25, 2025 | STEPHENSON BRIAN C | Open Market Sale | 8500 | 33.19 | $ 282,114.88 | 
| Feb 19, 2025 | STEPHENSON BRIAN C | Open Market Sale | 4148 | 36.16 | $ 149,973.43 | 
| Feb 19, 2025 | Kumar Neil | Open Market Sale | 31543 | 36.14 | $ 1,140,024.26 | 
| Feb 16, 2025 | Trimarchi Thomas | Option Excercise | 13782 | 34.90 | $ 480,991.80 | 
| Feb 16, 2025 | STEPHENSON BRIAN C | Option Excercise | 25798 |  | $ 0.00 | 
| Feb 16, 2025 | STEPHENSON BRIAN C | Option Excercise | 13102 | 34.90 | $ 457,259.80 | 
| Feb 16, 2025 | Kumar Neil | Option Excercise | 55539 |  | $ 0.00 | 
| Feb 16, 2025 | Kumar Neil | Option Excercise | 23996 | 34.90 | $ 837,460.40 | 
| Jan 31, 2025 | Shabet Rose Sharon | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | VIKING GLOBAL INVESTORS LP | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | Viking Global Opportunities Parent GP LLC | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | Viking Global Opportunities GP LLC | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | Viking Global Opportunities Portfolio GP LLC | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | Viking Global Opportunities Illiquid Investments Sub-Master LP | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | HALVORSEN OLE ANDREAS | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 31, 2025 | Ott David C. | Open Market Sale | 3065616 | 34.90 | $ 106,989,998.40 | 
| Jan 28, 2025 | Kumar Neil | Open Market Sale | 600000 | 36.31 | $ 21,788,650.42 | 
| Jan 28, 2025 | STEPHENSON BRIAN C | Option Excercise | 68000 | 17.00 | $ 1,156,000.00 | 
| Jan 28, 2025 | STEPHENSON BRIAN C | Open Market Sale | 68000 | 36.29 | $ 2,467,760.80 | 
| Dec 30, 2024 | Satvat Ali J. | Option Excercise | 159404 | 16.22 | $ 2,585,134.37 | 
| Dec 26, 2024 | MCCORMICK FRANK | Other Disposition | 7400 | 0.00 | $ 0.00 | 
| Dec 24, 2024 | Kumar Neil | Other Disposition | 9371450 | 0.00 | $ 0.00 | 
| Dec 10, 2024 | Trimarchi Thomas | Grant | 50000 | 0.00 | $ 0.00 | 
| Nov 19, 2024 | Kumar Neil | Open Market Sale | 27389 | 22.41 | $ 613,825.89 | 
| Nov 19, 2024 | STEPHENSON BRIAN C | Open Market Sale | 4156 | 22.41 | $ 93,136.79 | 
| Nov 16, 2024 | STEPHENSON BRIAN C | Option Excercise | 25799 |  | $ 0.00 | 
| Nov 16, 2024 | STEPHENSON BRIAN C | Option Excercise | 13077 | 23.72 | $ 310,186.44 | 
| Nov 16, 2024 | Trimarchi Thomas | Option Excercise | 17936 | 23.72 | $ 425,441.92 |