| May 15, 2025 | Alexander Robert | Other Disposition | 1058404 | | $ 0.00 |
| May 15, 2025 | Tomasi Adam | Other Disposition | 533420 | | $ 0.00 |
| May 15, 2025 | Radford Harlan Baird | Other Disposition | 163426 | | $ 0.00 |
| May 15, 2025 | Walker Paul Edward | Other Disposition | 6147260 | | $ 0.00 |
| May 15, 2025 | BVF PARTNERS L P/IL | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BIOTECHNOLOGY VALUE FUND L P | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BVF I GP LLC | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BIOTECHNOLOGY VALUE FUND II LP | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BVF II GP LLC | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | Biotechnology Value Trading Fund OS LP | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BVF Partners OS Ltd. | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BVF GP HOLDINGS LLC | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | BVF INC/IL | Other Disposition | 16312872 | | $ 0.00 |
| May 15, 2025 | LAMPERT MARK N | Other Disposition | 16312872 | | $ 0.00 |
| Mar 6, 2025 | Alexander Robert | Option Excercise | 31370 | 0.26 | $ 8,156.20 |
| Mar 5, 2025 | Tomasi Adam | Option Excercise | 20017 | 0.26 | $ 5,204.42 |
| Mar 5, 2025 | Radford Harlan Baird | Option Excercise | 14161 | 0.26 | $ 3,681.86 |