| Oct 29, 2025 | Stueland Katherine | Option Excercise | 3874 | 0.00 | $ 0.00 |
| Oct 29, 2025 | Stueland Katherine | Open Market Sale | 2158 | 136.54 | $ 294,654.16 |
| Oct 29, 2025 | Feeley Kevin | Option Excercise | 753 | 0.00 | $ 0.00 |
| Oct 29, 2025 | Feeley Kevin | Open Market Sale | 388 | 136.54 | $ 52,977.52 |
| Sep 30, 2025 | Stueland Katherine | Open Market Sale | 12858 | 108.17 | $ 1,390,911.39 |
| Sep 30, 2025 | Feeley Kevin | Option Excercise | 1246 | 32.67 | $ 40,706.82 |
| Sep 30, 2025 | Feeley Kevin | Open Market Sale | 6609 | 108.38 | $ 716,260.65 |
| Sep 16, 2025 | Feeley Kevin | Option Excercise | 7197 | 0.00 | $ 0.00 |
| Sep 16, 2025 | Feeley Kevin | Open Market Sale | 3728 | 121.47 | $ 452,850.23 |
| Sep 16, 2025 | Stueland Katherine | Option Excercise | 18750 | 0.00 | $ 0.00 |
| Sep 16, 2025 | Stueland Katherine | Open Market Sale | 10501 | 121.47 | $ 1,275,584.82 |
| Sep 16, 2025 | Feeley Kevin | Option Excercise | 7197 | 0.00 | $ 0.00 |
| Sep 9, 2025 | Feeley Kevin | Option Excercise | 2462 | 0.00 | $ 0.00 |
| Sep 9, 2025 | Feeley Kevin | Open Market Sale | 1272 | 128.05 | $ 162,885.84 |
| Sep 9, 2025 | Stueland Katherine | Option Excercise | 6546 | 0.00 | $ 0.00 |
| Sep 9, 2025 | Stueland Katherine | Open Market Sale | 3657 | 128.06 | $ 468,297.37 |
| Sep 2, 2025 | Feeley Kevin | Open Market Sale | 378 | 125.81 | $ 47,556.03 |
| Sep 1, 2025 | Feeley Kevin | Option Excercise | 717 | 0.00 | $ 0.00 |
| Aug 27, 2025 | Ryan Jason | Open Market Sale | 39222 | 127.37 | $ 4,995,800.61 |
| Aug 22, 2025 | Casdin Capital, LLC | Open Market Sale | 500000 | 120.90 | $ 60,451,950.00 |
| Aug 22, 2025 | Casdin Partners Master Fund, L.P. | Open Market Sale | 500000 | 120.90 | $ 60,451,950.00 |
| Aug 22, 2025 | Casdin Partners GP, LLC | Open Market Sale | 500000 | 120.90 | $ 60,451,950.00 |
| Aug 22, 2025 | Casdin Eli | Open Market Sale | 500000 | 120.90 | $ 60,451,950.00 |
| Jul 29, 2025 | Feeley Kevin | Option Excercise | 753 | 0.00 | $ 0.00 |
| Jul 29, 2025 | Feeley Kevin | Open Market Sale | 388 | 105.31 | $ 40,860.28 |
| Jul 29, 2025 | Stueland Katherine | Option Excercise | 3874 | 0.00 | $ 0.00 |
| Jul 29, 2025 | Stueland Katherine | Open Market Sale | 2154 | 105.31 | $ 226,837.74 |
| Jul 9, 2025 | Stueland Katherine | Open Market Sale | 3220 | 93.00 | $ 299,460.00 |
| Jul 9, 2025 | Feeley Kevin | Option Excercise | 1245 | 32.67 | $ 40,674.15 |
| Jul 9, 2025 | Feeley Kevin | Open Market Sale | 5278 | 93.00 | $ 490,854.00 |
| Jul 1, 2025 | Stueland Katherine | Open Market Sale | 9657 | 90.94 | $ 878,180.62 |
| Jul 1, 2025 | Feeley Kevin | Open Market Sale | 1344 | 91.12 | $ 122,471.24 |
| Jun 18, 2025 | Casdin Eli | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 18, 2025 | Meister Keith A. | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 18, 2025 | RUCH JOSHUA | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 18, 2025 | Ryan Jason | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 18, 2025 | Leproust Emily M. | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 18, 2025 | PFENNIGER RICHARD C JR | Option Excercise | 12924 | 0.00 | $ 0.00 |
| Jun 16, 2025 | Feeley Kevin | Option Excercise | 7197 | 0.00 | $ 0.00 |
| Jun 16, 2025 | Feeley Kevin | Open Market Sale | 3729 | 64.77 | $ 241,538.52 |
| Jun 16, 2025 | Stueland Katherine | Option Excercise | 18750 | 0.00 | $ 0.00 |
| Jun 16, 2025 | Stueland Katherine | Open Market Sale | 10501 | 64.77 | $ 680,181.27 |
| Jun 9, 2025 | Feeley Kevin | Option Excercise | 2462 | 0.00 | $ 0.00 |
| Jun 9, 2025 | Feeley Kevin | Open Market Sale | 1266 | 72.55 | $ 91,848.30 |
| Jun 9, 2025 | Stueland Katherine | Option Excercise | 6547 | 0.00 | $ 0.00 |
| Jun 9, 2025 | Stueland Katherine | Open Market Sale | 3639 | 72.55 | $ 264,009.45 |
| Jun 2, 2025 | Feeley Kevin | Open Market Sale | 370 | 71.26 | $ 26,366.20 |
| Jun 1, 2025 | Feeley Kevin | Option Excercise | 718 | 0.00 | $ 0.00 |
| May 14, 2025 | Meister Keith A. | Open Market Purchase | 50000 | 60.16 | $ 3,007,997.24 |
| May 14, 2025 | Corvex Management LP | Open Market Purchase | 50000 | 60.16 | $ 3,007,997.24 |
| May 8, 2025 | Meister Keith A. | Open Market Purchase | 100000 | 56.01 | $ 5,600,994.47 |
| May 8, 2025 | Corvex Management LP | Open Market Purchase | 100000 | 56.01 | $ 5,600,994.47 |
| May 2, 2025 | PFENNIGER RICHARD C JR | Option Excercise | 918 | 0.00 | $ 0.00 |
| May 2, 2025 | Meister Keith A. | Grant | 434848 | 63.94 | $ 27,802,118.82 |
| May 2, 2025 | Corvex Management LP | Grant | 434848 | 63.94 | $ 27,802,118.82 |
| Apr 30, 2025 | Feeley Kevin | Grant | 420 | 56.82 | $ 23,865.45 |
| Apr 29, 2025 | Stueland Katherine | Option Excercise | 3874 | 0.00 | $ 0.00 |
| Apr 29, 2025 | Stueland Katherine | Open Market Sale | 2154 | 113.09 | $ 243,595.86 |
| Apr 29, 2025 | Feeley Kevin | Option Excercise | 753 | 0.00 | $ 0.00 |
| Apr 29, 2025 | Feeley Kevin | Open Market Sale | 388 | 113.09 | $ 43,878.92 |
| Apr 9, 2025 | Stueland Katherine | Open Market Sale | 46594 | 89.62 | $ 4,175,816.57 |
| Apr 9, 2025 | Feeley Kevin | Option Excercise | 1246 | 32.67 | $ 40,706.82 |
| Apr 9, 2025 | Feeley Kevin | Open Market Sale | 15516 | 92.18 | $ 1,430,334.38 |
| Mar 26, 2025 | Feeley Kevin | Option Excercise | 16250 | 0.00 | $ 0.00 |
| Mar 26, 2025 | Feeley Kevin | Open Market Sale | 8746 | 95.61 | $ 836,210.93 |
| Mar 26, 2025 | Stueland Katherine | Option Excercise | 80000 | 0.00 | $ 0.00 |
| Mar 26, 2025 | Stueland Katherine | Open Market Sale | 46551 | 95.62 | $ 4,451,084.37 |
| Mar 16, 2025 | Stueland Katherine | Option Excercise | 18750 | 0.00 | $ 0.00 |
| Mar 16, 2025 | Feeley Kevin | Option Excercise | 7197 | 0.00 | $ 0.00 |
| Mar 13, 2025 | Stueland Katherine | Open Market Sale | 11637 | 96.04 | $ 1,117,566.42 |
| Mar 13, 2025 | Feeley Kevin | Open Market Sale | 4151 | 96.07 | $ 398,766.83 |
| Mar 10, 2025 | Stueland Katherine | Open Market Sale | 2731 | 94.73 | $ 258,695.07 |
| Mar 10, 2025 | Feeley Kevin | Open Market Sale | 922 | 94.72 | $ 87,334.24 |
| Mar 9, 2025 | Stueland Katherine | Option Excercise | 6546 | 0.00 | $ 0.00 |
| Mar 9, 2025 | Feeley Kevin | Option Excercise | 2462 | 0.00 | $ 0.00 |
| Mar 3, 2025 | Feeley Kevin | Open Market Sale | 261 | 103.94 | $ 27,128.34 |
| Mar 1, 2025 | Feeley Kevin | Option Excercise | 717 | 0.00 | $ 0.00 |
| Feb 5, 2025 | RUCH JOSHUA | Option Excercise | 5816 | 7.89 | $ 45,888.24 |
| Jan 29, 2025 | Feeley Kevin | Option Excercise | 753 | 0.00 | $ 0.00 |
| Jan 29, 2025 | Feeley Kevin | Open Market Sale | 275 | 78.48 | $ 21,582.11 |
| Jan 29, 2025 | Stueland Katherine | Option Excercise | 3874 | 0.00 | $ 0.00 |
| Jan 29, 2025 | Stueland Katherine | Open Market Sale | 1657 | 78.48 | $ 130,046.00 |
| Jan 17, 2025 | RUCH JOSHUA | Option Excercise | 3000 | 7.89 | $ 23,670.00 |
| Jan 7, 2025 | Feeley Kevin | Option Excercise | 11208 | 32.67 | $ 366,165.36 |
| Jan 7, 2025 | Feeley Kevin | Open Market Sale | 35506 | 93.82 | $ 3,331,024.29 |
| Jan 7, 2025 | Stueland Katherine | Open Market Sale | 51420 | 94.48 | $ 4,858,118.95 |
| Dec 16, 2024 | Stueland Katherine | Option Excercise | 18750 | 0.00 | $ 0.00 |
| Dec 16, 2024 | Stueland Katherine | Open Market Sale | 10501 | 76.75 | $ 805,994.80 |
| Dec 16, 2024 | Feeley Kevin | Option Excercise | 7197 | 0.00 | $ 0.00 |
| Dec 16, 2024 | Feeley Kevin | Open Market Sale | 3728 | 76.75 | $ 286,139.28 |
| Dec 9, 2024 | Feeley Kevin | Option Excercise | 2462 | 0.00 | $ 0.00 |
| Dec 9, 2024 | Feeley Kevin | Open Market Sale | 1137 | 76.37 | $ 86,835.87 |
| Dec 9, 2024 | Stueland Katherine | Option Excercise | 6547 | 0.00 | $ 0.00 |
| Dec 9, 2024 | Stueland Katherine | Open Market Sale | 3661 | 76.37 | $ 279,597.53 |
| Dec 2, 2024 | Feeley Kevin | Open Market Sale | 263 | 78.39 | $ 20,616.89 |
| Nov 21, 2024 | Feeley Kevin | Open Market Sale | 22000 | 74.81 | $ 1,645,810.27 |
| Nov 19, 2024 | Ryan Jason | Other Disposition | 141356 | 0.00 | $ 0.00 |
| Nov 19, 2024 | Ryan Jason | Open Market Sale | 47000 | 70.57 | $ 3,316,879.80 |
| Nov 15, 2024 | Stueland Katherine | Open Market Sale | 45415 | 70.41 | $ 3,197,684.33 |
| Nov 15, 2024 | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | Open Market Sale | 147141 | 70.64 | $ 10,393,722.68 |
| Nov 15, 2024 | MOUNT SINAI HEALTH SYSTEM, INC. | Open Market Sale | 147141 | 70.64 | $ 10,393,722.68 |